Home Epigenetics p300/CBP inhibitor E7386

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E7386 CBP/beta-catenin Inhibitor

Cat.No.E1348

E-7386 is a selective inhibitor which inhibits interaction between CBP/beta-catenin with IC50 value of 0.0484 μM in HEK293 cells.
E7386 p300/CBP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 725.86

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Quality Control

Batch: E134801 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.32%
99.32

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (137.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 725.86 Formula

C39H48FN9O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1799824-08-0 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
CBP/beta-catenin
0.0484 μM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05607537 Completed
Healthy Volunteers
Eisai Limited|Eisai Inc.
 October 17 2022 Phase 1
NCT05091346 Recruiting
Melanoma|Carcinoma Hepatocellular|Colorectal Neoplasms
Eisai Inc.|Merck Sharp & Dohme LLC
 October 27 2021 Phase 1|Phase 2
NCT04840927 Withdrawn
Healthy Volunteers
Eisai Limited|Eisai Inc.
 April 9 2021 Phase 1
NCT04008797 Recruiting
Neoplasms|Carcinoma Hepatocellular|Liver Neoplasms|Colorectal Neoplasms|Endometrial Neoplasms
Eisai Inc.
 July 11 2019 Phase 1
NCT03996226 Completed
Food Effect in Healthy Participants
Eisai Inc.
 June 7 2019 Phase 1
NCT03833700 Active not recruiting
Solid Neoplasms|Colorectal Neoplasms|Gastrointestinal Tumors
Eisai Co. Ltd.|Eisai Inc.
 March 5 2019 Phase 1

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