RNA Methyltransferase

Other Epigenetics Related Inhibitors

Histone Methyltransferase BET DNA Methyltransferase p300/CBP Histone Demethylase Histone Acetyltransferase MicroRNA NSD EZH1 SF3B

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S9870	STM2457	STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.	Nat Commun, 2025, 16(1):4457 Cell Rep, 2025, S2211-1247(25)01101-5 J Virol, 2025, e0228424.
E1728	STC-15	STC-15 is an oral, small-molecule inhibitor of RNA methyltransferase METTL3. It inhibits tumor growth through the activation of anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S9870

STM2457

STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.

Nat Commun, 2025, 16(1):4457

Cell Rep, 2025, S2211-1247(25)01101-5

J Virol, 2025, e0228424.

E1728

STC-15

STC-15 is an oral, small-molecule inhibitor of RNA methyltransferase METTL3. It inhibits tumor growth through the activation of anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade.