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p300/CBP Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S2662 ICG-001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
Adv Sci (Weinh), 2025, 12(40):e05702
Cell Rep Med, 2025, 6(2):101927
Verified customer review of ICG-001
S8968 PRI-724 (Foscenvivint) Foscenvivint (PRI-724) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
Cancer Discov, 2025, 10.1158/2159-8290.CD-25-0629
Cell Death Dis, 2025, 16(1):466
Biomed Pharmacother, 2025, 188:118225
S0022 YF-2 YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, this compound has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. It also increases p300 activity.
J Extracell Vesicles, 2025, 14(2):e70042
J Exp Clin Cancer Res, 2022, 41(1):77