EZH1

Other Epigenetics Related Inhibitors

Histone Methyltransferase BET DNA Methyltransferase p300/CBP Histone Demethylase Histone Acetyltransferase MicroRNA NSD RNA Methyltransferase SF3B

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7165	UNC1999	UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. This compound is a potent autophagy inducer. It specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.	Cell Stem Cell, 2025, S1934-5909(25)00041-4 Cell Rep, 2025, 44(5):115673 bioRxiv, 2025, 2025.05.22.655558
S7656	CPI-360	CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.	Nature Communications, 2024, 4770 Protein & Cell, 2022, 683-688 Mol Ther Oncolytics, 2022, 27:14-25

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7165

UNC1999

UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. This compound is a potent autophagy inducer. It specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.

Cell Stem Cell, 2025, S1934-5909(25)00041-4

Cell Rep, 2025, 44(5):115673

bioRxiv, 2025, 2025.05.22.655558

S7656

CPI-360

CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.

Nature Communications, 2024, 4770

Protein & Cell, 2022, 683-688

Mol Ther Oncolytics, 2022, 27:14-25