NLRP3

NLRP3 Products

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  • NLRP3 Inhibitors (14)
  • NLRP3 Activator (1)
  • NLRP3 Agonist (1)
  • New NLRP3 Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7809 MCC950 Sodium MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Int J Oral Sci, 2024, 16(1):3
Gut Microbes, 2023, 15(1):2192478
J Exp Clin Cancer Res, 2023, 42(1):26
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Death Dis, 2024, 15(1):43
J Transl Med, 2024, 22(1):23
Ecotoxicol Environ Saf, 2024, 272:116004
S6653 Nigericin sodium salt Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
EMBO J, 2023, e113118.
J Neuroinflammation, 2023, 20(1):82
Br J Pharmacol, 2023, 10.1111/bph.16058
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
Antioxidants (Basel), 2023, 12(3)722
J Exp Clin Cancer Res, 2022, 41(1):74
Int J Mol Sci, 2022, 23(19)11707
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Chin Med J (Engl), 2022, 135(12):1474-1485
Biomed Res Int, 2022, 2022:7250578
Int Immunopharmacol, 2021, 92:107358
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
eprints, 2023, 10.14943/doctoral.k15475
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
iScience, 2023, 26(3):106089
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138 YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.

S3290 Procyanidin B2 Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

E3652 Rehmanniae radix praeparata Extract Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E3367 Garlic chives Extract Garlic chives Extract is extracted from Allium tuberosum, which provides a new therapeutic in the treatment of NLRP3 inflammasome-driven diseases.
E1281 Dimethyl itaconate Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

E0225 Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

S7809 MCC950 Sodium MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Int J Oral Sci, 2024, 16(1):3
Gut Microbes, 2023, 15(1):2192478
J Exp Clin Cancer Res, 2023, 42(1):26
S8930 MCC950 MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
Cell Death Dis, 2024, 15(1):43
J Transl Med, 2024, 22(1):23
Ecotoxicol Environ Saf, 2024, 272:116004
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself. It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
Antioxidants (Basel), 2023, 12(3)722
J Exp Clin Cancer Res, 2022, 41(1):74
Int J Mol Sci, 2022, 23(19)11707
S8559 INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
Chin Med J (Engl), 2022, 135(12):1474-1485
Biomed Res Int, 2022, 2022:7250578
Int Immunopharmacol, 2021, 92:107358
S3680 NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
eprints, 2023, 10.14943/doctoral.k15475
Am J Pathol, 2022, S0002-9440(22)00076-1
Immunopharmacol Immunotoxicol, 2022, 1-24
S8907 Dapansutrile Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.
iScience, 2023, 26(3):106089
S3871 Muscone Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).
J Pharm Pharmacol, 2019, 71(11):1706-1713
S3939 4'-Methoxyresveratrol 4-Methoxyresveratrol is a stibenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E0138 YQ128

YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 µM.

S3290 Procyanidin B2 Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
E3652 Rehmanniae radix praeparata Extract Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E3367 Garlic chives Extract Garlic chives Extract is extracted from Allium tuberosum, which provides a new therapeutic in the treatment of NLRP3 inflammasome-driven diseases.
S9261 Shionone

Shionone is a triterpenoid component derived from the herbal medicine Aster tataricus, anit has anti-inflammatory properties. Shionone specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.

E0225 Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

S6653 Nigericin sodium salt Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
EMBO J, 2023, e113118.
J Neuroinflammation, 2023, 20(1):82
Br J Pharmacol, 2023, 10.1111/bph.16058
S9899 BMS-986299

BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.

Choose Selective NLRP3 Inhibitors

Tags: NLRP3 inhibitor|NLRP3 agonist|NLRP3 activator|NLRP3 inducer|NLRP3 antagonist|NLRP3 signaling pathway|NLRP3 assay kit