Home Metabolism Lipase

Lipase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2365 Tanshinone IIA Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; this compound is a natural monoacylglycerol lipase inhibitor.
Phytomedicine, 2024, 128:155431
J Cancer, 2023, 14(13):2481-2490
Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12663
Verified customer review of Tanshinone IIA
S1629 Orlistat Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. This compound treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Cell Rep, 2025, 44(7):115901
Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01477-y
J Cell Sci, 2024, 137(20)jcs262162
S7364 Atglistatin Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.
Hepatology Communications, October 2023, e0277
Cell Reports, November 2025, 116526
Nat Commun, 2025, 16(1):4432
Verified customer review of Atglistatin
S4904 JZL184 JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Biomed Pharmacother, 2022, 149:112798
J Cardiovasc Transl Res, 2022, 10.1007/s12265-022-10323-z
S9234 Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. This compound inhibits the expression of TLR4 and Myd88. It also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
Journal of Pharmacological Sciences, 2019, 15-22
S9404 Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. This compound can inhibit monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.
Cell Death & Disease, April 14, 2020, 232
Cell Death & Disease, 2020, 232
Cell Death Dis, 2020, 14;11(4):232
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
Cell Death & Disease, 2022, 1067
S7457 XEN445 XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S7543 JW642 JW642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
S6550 URB602 URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).
E5796 CAY10499 CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC₅₀ values of 144 nM for human recombinant monoacylglycerol lipase (MAGL), 90 nM for hormone-sensitive lipase (HSL), and 14 nM for fatty acid amide hydrolase (FAAH). It also inhibits cell growth in MCF-7, MB-231, COV318, OVCAR-3 cancer cell lines.
S4930 Cetilistat Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
E1752 JNJ-42226314 JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). It enhances the expression of endocannabinoid 2-arachidonoylglycerol (2-AG) and exhibits antinociceptive efficacy in models of neuropathic and inflammatory pain.
S6609 JZL195 JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.