YH239-EE

Catalog No.S7489

YH239-EE Chemical Structure

Molecular Weight(MW): 504.41

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

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Biological Activity

Description YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
Targets
p53/MDM2 [1]
In vitro

YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: OCI-AML-3 cells
  • Concentrations: ~50 μM
  • Incubation Time: 72 hours
  • Method: Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (198.25 mM)
Ethanol 18 mg/mL (35.68 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 504.41
Formula

C25H27Cl2N3O4

CAS No. 1364488-67-4
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID