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Sulfamerazine Bacterial chemical

Cat.No.S3132

Sulfamerazine (RP 2632,sulphamerazine) is a sulfonamide antibacterial.
Sulfamerazine Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 264.3

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S313201 DMSO]53 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

Chemical Information, Storage & Stability

Molecular Weight 264.3 Formula

C11H12N4O2S

 Storage (From the date of receipt)
CAS No. 127-79-7 Download SDF Storage of Stock Solutions

Synonyms RP 2632,sulphamerazine Smiles CC1=NC(=NC=C1)NS(=O)(=O)C2=CC=C(C=C2)N

Solubility

In vitro
Batch:

DMSO : 53 mg/mL (200.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

Sulfamerazine exhibits biexponential decay in water and triexponential decay in cyclodextrins solutions. This compound shows remarkably upfield shift in the complexes suggested that the aniline ring deeply encapsulated in the CD cavity. [1]
In vivo

Sulfamerazine results in a marked evolution in the shape of the concentration-time curves in function of age, strongly suggesting a defective absorption rate in the first weeks after birth in lambs. [2] This compound has a significantly beneficial effect on life span of rats and apparently increases that of male hamsters, and all rats fed this chemical attains higher maximum weights than their controls. [3]
References

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