Catalog No.S4152 Synonyms: Etamsylate
Molecular Weight(MW): 263.31
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
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|Description||Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.|
Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM.  Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187. 
|In vivo||Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema. |
|In vitro||DMSO||53 mg/mL (201.28 mM)|
|Water||53 mg/mL (201.28 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02604719||Not yet recruiting||Postpartum Hemorrhage||Ahmed Alanwar|Ain Shams University||November 2015||Phase 1|Phase 2|
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