Ethamsylate

Catalog No.S4152 Synonyms: Etamsylate

Ethamsylate Chemical Structure

Molecular Weight(MW): 263.31

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

Size Price Stock Quantity  
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Targets
prostaglandins [1]
In vitro

Ethamsylate inhibits prostaglandin bio-synthesis in microsomes of pregnant human myometrium with IC50 of 0.5 mM. [1] Ethamsylate is particularly active against hydroxyl radicals (OH.), which are scavenged at therapeutic Ethamsylate concentrations (0.1–10 μM). Higher Ethamsylate concentrations are required to scavenge superoxide radicals. Ethamsylate potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium ionophore A23187. [2]

In vivo Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits. By the intravenous route, Ethamsylate reduces bleeding time by half at doses >5 mg/kg. The effect starts 5 minutes after the injection, reaches a maximum between 30 minutes and 4 hours after the injection, and disappears after 6 hours. By the oral route, a similar maximal action is observed at the dose of 10 mg/kg. The efficacy of Ethamsylate to reduce intraventricular hemorrhage is associated with a reduction of thromboxane A2 and prostacyclin biosynthesis. Orally given Ethamsylate (>25 mg/kg) also inhibits carrageenan-induced rat paw edema. [2]

Protocol

Solubility (25°C)

In vitro DMSO 53 mg/mL (201.28 mM)
Water 53 mg/mL (201.28 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 263.31
Formula

C6H6O5S.C4H11N

CAS No. 2624-44-4
Storage powder
Synonyms Etamsylate

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02604719 Not yet recruiting Postpartum Hemorrhage Ahmed Alanwar|Ain Shams University November 2015 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Antibodies

Tags: buy Ethamsylate | Ethamsylate ic50 | Ethamsylate price | Ethamsylate cost | Ethamsylate solubility dmso | Ethamsylate purchase | Ethamsylate manufacturer | Ethamsylate research buy | Ethamsylate order | Ethamsylate mouse | Ethamsylate chemical structure | Ethamsylate mw | Ethamsylate molecular weight | Ethamsylate datasheet | Ethamsylate supplier | Ethamsylate in vitro | Ethamsylate cell line | Ethamsylate concentration | Ethamsylate nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID