(E)-Cardamonin

Catalog No.S3867 Batch:S386701

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Technical Data

Formula

C16H14O4
Molecular Weight 270.28 CAS No. 19309-14-9
Solubility (25°C)* In vitro DMSO 87 mg/mL (321.88 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.
Targets
NF-κB [2]
(Cell-free assay)		 TRPA1 [1]
(Cell-free assay)
454 nM
In vitro Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1].
In vivo Cardamonin inhibits tumor growth in vivo without serious side effects[2].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    NPC cells

  • Concentrations

    10 μM

  • Incubation Time

    24, 48 and 72 h

  • Method

    Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO, absorbance is measured after 24, 48 and 72 h of treatment.

Animal Study:[2]
  • Animal Models

    Xenograft model (BALB/c nude mice)

  • Dosages

    5 mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.