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Colistin Sulfate

Name: Colistin Sulfate
Brand: Selleck Chemicals
SKU: S4029
Rating: 5 (2 reviews)

Synonyms: Polymixin E Sulfate

Catalog No.S4029 Purity: 99%

Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.

Colistin Sulfate Chemical Structure

CAS: 1264-72-8

Selleck's Colistin Sulfate has been cited by 2 publications

Purity & Quality Control

Antibiotic Titer ≥ 19000 u/mg
Finest quality approved by Nature Medicine
COA
Datasheet
SDS

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Choose Selective Bacterial Inhibitors

Biological Activity

Description	Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.

In vitro
In vitro	Colistin (2 μg/mL) is active against most strains of Escherichia coli and P. aeruginosa, and all species of Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Proteus, Serratia, Providencia. Colistin inhibits 225 strains of P.aeruginosa with MIC90 and MIC50 of 6.3 μg/mL and 1.6μg/mL, respectively. Colistin sulfate is approved only for topical and oral use because of its toxicity. ^[1] Colistin sulfate is administered orally (tablets or syrup) for bowel decontamination and topically as a powder for the treatment of bacterial skin infections. Colistin interacts with the bacterial membrane through electrostatic interactions between the cationic polypeptide (colistin) and anionic lipopolysaccharide (LPS) molecules in the outer membrane of the gram-negative bacteria, leading to derangement of the cell membrane. Colistin displaces magnesium (Mg⁺²) and calcium (Ca⁺²), which normally stabilize the LPS molecules, from the negatively charged LPS, leading to a local disturbance of the outer membrane. Colistin has also potent anti-endotoxin activity. ^[2] Colistin sulfate produces a strong postantibiotic effects against Acinetobacter baumannii ranging from 2.5 hours to 7.0 hours in a concentration-dependent manner. ^[3]

In Vivo
In vivo	Colistin sulfate (5%, i.m.) causes the muscle circumference to appear erythematic in mice. Colistin sulfate (i.m., 15 mg/kg/day for 5 days) causes obvious neurotoxicity to piglets with moderate granular degenerations in the epithelial tissues from kidney and liver of mice. Colistin sulfate (i.m.) at dose of 2.5 mg/kg and 5.0 mg/kg results in Cmax of 3.73 mg/mL and 6.40 mg/mL, Tmax of 32 min and 34 min, t(1/2beta) of 256 min and 264 min, and absolute bioavailability of 95.94% and 88.45% in mice. ^[4]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06087536	Not yet recruiting	Hospital-acquired Bacterial Pneumonia\|Ventilator-associated Bacterial Pneumonia	Omnix Medical Ltd	January 2024	Phase 2
NCT05542446	Recruiting	Colistin	St. Anne''s University Hospital Brno Czech Republic\|Palacky University	September 1 2022	Phase 4
NCT04775238	Unknown status	Nosocomial Infections	Sohag University	February 27 2021	Not Applicable
NCT04208945	Unknown status	Pneumonia Ventilator-associated\|Gram-Negative Pneumonia	University of Thessaly	December 2019	Not Applicable
NCT03971877	Completed	Colistin Resistance in Bacteria	University Hospital Bordeaux	December 16 2019	--

References

[4] Lin B, et al. J Vet Pharmacol Ther, 2005, 28(4), 349-354.

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Chemical Information & Solubility

Molecular Weight	1400.63	Formula	C₅₂H₉₈N₁₆O₁₃.5/2H₂SO₄
CAS No.	1264-72-8	SDF	Download Colistin Sulfate SDF
Smiles	CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC2CC
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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