Home Microbiology Bacterial inhibitor Closantel Sodium

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Closantel Sodium Bacterial inhibitor

Cat.No.S4105

Closantel is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM.
Closantel Sodium Bacterial inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 685.06

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Quality Control

Batch: S410501 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.8%
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99.8

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (145.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 685.06 Formula

C22 H13 Cl2I2N2O2.Na

 Storage (From the date of receipt)
CAS No. 61438-64-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)[O-])Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na+]

Mechanism of Action

In vitro
Closantel inhibits drug resistant S. aureus and E. faecium with MICs of 1 μg/mL and 1 μg/mL. Closantel inhibits MRSA and E.faecalis with MICs of 2 μg/mL and 1 μg/mL. Closantel completely blocks the infection of host cells with E. chaffeensis or A. phagocytophilum, treatment of infected cells 1 day post infection with closantel clears infection in dose-dependent manner. Closantel inhibits the autokinase activities of the three E. chaffeensis sensor kinases from E. chaffeensis. Closantel (50 μg/mL) causes an initial burst of contractions of much greater amplitude and frequency than normal in tissue vessel, the stimulation of amplitude and frequency lasted for nearly 15 min and is accompanied by a rise in muscle tone, which reaches a maximum at 16 min, at a level greater than 1.5 times the maximal normal amplitude.
In vivo
Closantel (10 mg/kg) results in gross surface damage from 24 hours onwards in rats administrated with 25 metacercarial cysts of F. hepatica, in the form of erosion of the anterior and posterior extremities of the fluke and large-scale sloughing of the tegument on both dorsal and ventral surfaces. Closantel (7.5 mg/kg) combined with broad-spectrum anthelmintic is very effective against H. contortus but ineffective against Trichostrongylus spp in lambs. Closantel significantly reduces isotope levels in closantel-resistant adult Haemonchus contortus infected sheep.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/3954695/
  • [5] https://pubmed.ncbi.nlm.nih.gov/9138034/

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