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Bismuth Subcitrate Potassium Bacterial chemical

Cat.No.S4093

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
Bismuth Subcitrate Potassium Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 782.67

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Quality Control

Batch: S409301 Water]141 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.92%
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99.92

Solubility

In vitro
Batch:

Water : 141 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 782.67 Formula

C12H8BiK5O14

 Storage (From the date of receipt)
CAS No. 880149-29-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+].[K+].[K+].[Bi+3]

Mechanism of Action

In vitro
Colloidal Bismuth Subcitrate is crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer, the solubility of Colloidal Bismuth Subcitrate in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. Bismuth Subcitrate is effective against the 12 C. pyloridis strains with MIC50 of 8 μg/mL. Bismuth Subcitrate combined with oxolinic acid exhibits synergistic activity against the 12 C. pyloridis strains. Colloidal bismuth subcitrate (5 mg/mL) significantly increases the frequencies of sister-chromatid exchange (SCE) and micronucleus rate in peripheral lymphocytes compared with controls in human whole blood cultures. Bismuth Subcitrate (100μM) inhibits Helicobacter pyloriF1-ATPase activity, and inhibition is prevented and reversed by the mercaptan glutathione, indicating that Bismuth Subcitrate interfere with sulfhydryl groups of the enzyme. Colloidal Bismuth Subcitrate (150 mg/mL) inhibits the lipolytic activity of C. pylori filtrate, causing a 21% reduction in lipase activity and a 60% reduction in the activity of phospholipase A.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/7667394/
  • [5] https://pubmed.ncbi.nlm.nih.gov/2801678/

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