Home GPCR & G Protein Angiotensin Receptor antagonist Valsartan For research use only.

Valsartan

Synonyms: CGP-48933

Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

Valsartan Chemical Structure

Valsartan Chemical Structure

CAS: 137862-53-4

Selleck's Valsartan has been cited by 4 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 100%
100

Valsartan Related Products

Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Valsartan is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.
Targets
angiotensin II receptor [1]
In vitro
In vitro Valsartan dose-dependently inhibits the vasoconstriction induced by angiotensin II and lowers blood pressure in renin-dependent models of hypertension. Valsartan is at least as effective as ACE inhibitors, diuretics, beta-blockers and calcium antagonists. [1]
In Vivo
In vivo Valsartan results in improved glucose tolerance, reduced fasting blood glucose levels, and reduced serum insulin levels in mice fed a Western diet. Valsartan treatment also blocks Western diet-induced increases in serum levels of the proinflammatory cytokines interferon-gamma and monocyte chemotactic protein 1. Valsartan enhances mitochondrial function and prevents Western diet-induced decreases in glucose-stimulated insulin secretion in the pancreatic islets of mice. Valsartan treatment blocks or attenuates Western diet-induced changes in expression of several key inflammatory signals: interleukin 12p40, interleukin 12p35, tumor necrosis factor-alpha, interferon-gamma, adiponectin, platelet 12-lipoxygenase, collagen 6, inducible NO synthase, and AT1R in isolated adipocytes. [2] Valsartan significantly increases insulin-mediated 2-[3H]deoxy-d-glucose (2-[3H]DG) uptake into skeletal muscle and attenuates the increase in plasma glucose concentration after a glucose load and plasma concentrations of glucose and insulin. Valsartan treatment exaggerates the insulin-induced phosphorylation of IRS-1, the association of IRS-1 with the p85 regulatory subunit of phosphoinositide 3 kinase (PI 3-K), PI 3-K activity, and translocation of GLUT4 to the plasma membrane. Valsartan also reduces tumor necrosis factor-alpha (TNF-alpha) expression and superoxide production in skeletal muscle of KK-Ay mice. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05989503 Recruiting
Heart Failure With Reduced Ejection Fraction
Universidade do Porto|Faculty of Medicine (FMUP)|Unidade de Investigação e Desenvolvimento Cardiovascular (UnIC)|Rede de Investigação em Saúde (RISE) Laboratório Associado
 August 4 2023 Phase 4
NCT05870709 Withdrawn
Heart Failure
Novartis Pharmaceuticals|Novartis
 May 15 2023 --
NCT05564572 Enrolling by invitation
Heart Failure
Stanford University
 September 7 2022 Not Applicable
NCT05194111 Recruiting
Heart Failure|Heart Dysfunction
Virginia Commonwealth University
 March 9 2022 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 435.52 Formula

C24H29N5O3
CAS No. 137862-53-4 SDF Download Valsartan SDF
Smiles CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 87 mg/mL ( (199.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 87 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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