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Meropenem Antibiotics chemical

Name: Meropenem
Brand: Selleck Chemicals
SKU: S1381
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S1381

Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic. This compound is used to treat a variety of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria. This chemical is often reserved for severe or high-risk cases due to its broad activity.

Chemical Structure

Molecular Weight: 383.46

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Quality Control

Batch: Purity: 99.08%

99.08

Related Targets	Integrase Bacterial Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Antibiotics Inhibitors	G418 Sulfate (Geneticin) Puromycin Nanchangmycin Sitafloxacin Hydrate Gamithromycin Thiamphenicol Fusidine Tildipirosin Spiramycin Nadifloxacin

Solubility

In vitro
Batch:

Water : 77 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	383.46	Formula	C₁₇H₂₅N₃O₅S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	96036-03-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SM 7338			Smiles	CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O

Mechanism of Action

In vitro	Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. This compound is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Its MICs are not significantly influenced by high inocula and the drug is generally bactericidal. It demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases. This antibiotic binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus. This chemical is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. It has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity.
In vivo	Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. This compound significantly increases the urinary excretion of valproate- glucuronide in rabbits.
References	[1] https://pubmed.ncbi.nlm.nih.gov/8543486/ [2] https://pubmed.ncbi.nlm.nih.gov/2808218/ [3] https://pubmed.ncbi.nlm.nih.gov/7768785/ [4] https://pubmed.ncbi.nlm.nih.gov/7652497/ [5] https://pubmed.ncbi.nlm.nih.gov/11683247/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06338345	Not yet recruiting	Cardiogenic Shock\|Post-cardiac Surgery\|Cardiac Arrest\|Extracorporeal Membrane Oxygenation Complication\|Infections	University Hospital Grenoble	September 1 2024	Not Applicable
NCT05784844	Recruiting	Febrile Neutropenia	Wake Forest University Health Sciences	April 2024	Phase 4
NCT04809259	Not yet recruiting	Infection Bacterial	University of Lausanne Hospitals	January 1 2024	Early Phase 1
NCT06087536	Not yet recruiting	Hospital-acquired Bacterial Pneumonia\|Ventilator-associated Bacterial Pneumonia	Omnix Medical Ltd	January 2024	Phase 2
NCT06089668	Recruiting	Melioidosis	AN2 Therapeutics Inc\|Mahidol Oxford Tropical Medicine Research Unit	November 1 2023	--

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