Home » By Product Pathways » Apoptosis » TNF-alpha » Lenalidomide
S1029

Lenalidomide (Revlimid)

 (Synonyms

CC-5013

)
Technical Data:
Add to Favor
Lenalidomide (Revlimid)
Click image to enlarge  
M.Wt: 259.26
Formula: C13H13N3O3
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 191732-72-6
Molarity Calculator   Dilution Calculator

Price and Availability of Lenalidomide (Revlimid):

  USD Qty  
50mg / $70In Stock
500mg / $470In Stock
Shipping and handling fee USD40
Bulk Inquiry with Discount

Applications & Customer's Feedback of Lenalidomide (Revlimid):

  • Lenalidomide was purchased from Selleck.Data was provided by Harvard Medical School.

    MM1S were treated with AT9283 (0.125 μM), lenalidomide (2 μM) or combined therapy for 72 hours. Annexin/PI staining show increased apoptosis associated with caspase 8 and PARP cleavage after 18 and 36 hours of exposure. B) MM.1S cells were treated with AT9283 (0.125 μM), lenalidomide (2 μM) or combined therapy for 4 hours. Whole lysates were immunoblotted with indicated antibodies

  • Lenalidomide was purchased from Selleck.Data was provided by Harvard Medical School.

    MM.1S cells were cultured for 48 hours in the presence or absence of BMSCs with control media, AT9283, lenalidomide or AT9283 plus lenalidomide. Cell proliferation was assessed by 3H-TdR uptake (left). MM.1S cells were cultured in the absence or presence of BMSCs and treated for 4 hours with drugs alone or in combination. Whole lysates were immunoblotted with indicated antibodies.

Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.  ------Loredana Santo,Teru Hideshima,et al.Clin Cancer Res.2011.May;17:3259-71

Biological Activity of Lenalidomide (Revlimid):

Lenalidomide is a derivative of thalidomide with antiangiogenic and antineoplastic properties(cell IC50= 10 μM). [1] It was initially intended as a treatment for multiple myeloma. [2]
Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. [3]

Quality Control:

MSDS
Batch  S102901: H-NMR  HPLC  COA
Batch  S102902: H-NMR  HPLC  COA

Related Products:
  • TNF-alpha
    • Free Sample and Reward:
    We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.)   See Details
    Share
    Buy Now / Print Quote

    Find Multiple Products by Catalog Number

    Continue
    Customer's Feedback
    Arnaud AUTRET, Trinity College
    "I would like to confirm you that everything is perfectly fine with ABT and Obatoclax we got from your company. We confirmed their activity in vitro. We notably observed their impact in an apoptotic model and results are similar to those which have been published."

    Dongfeng Chen, The Rausing Lab
    "Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future."

    Dr. Alexandra Segref, CECAD Cologne,Germay
    "I am very satisfied with your product and costumer service. Bortezomib works very well in our assay, it is comparably cheaper than other inhibitors that we tested is more reliable for our assays. We see a great effect by using 10nM concentration."

    R.B. Cambridge
    "I have used the chemical that I bought from you(Selleck,PTC-124) and it worked well.So we will eventually be ordering more."

    Zhenghe John Wang Assistant Professor, Case Western Reserve University
    "We have purchased LBH-589, Saha and MS-275 from you and they all worked well."

    Jenny Sun
    "We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility."

    Yu Wang, Harvard University
    "The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research."

    Philip Seeman, Toronto University
    "Your LY404039 compound was well synthesized, its complicated stereochemical structure confirmed by NMR spectroscopy, and was biologically excellent in acting on brain dopamine receptors."

    Dung-Fang Lee
    "Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells."

    Latest Catalog
    Jun 2011
    Selleck
    Latest
    Catalog

    		Selleck Chemicals Catalog
    | Inhibitor | Antibody | siRNA | Protein | Peptide | Cell Signal | © Copyright 2010 Selleck. All Rights Reserved.