Molecular Weight(MW): 390.41
LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
Purity & Quality Control
Choose Selective BACE Inhibitors
|Description||LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.|
LY2886721 is an oral, small molecule of β-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of β-amyloid and thereby to slow the clinical progression of AD.  LY2886721 can also targetγ-secretase to nhibit the synthesis of β-amyloid. 
|In vitro||DMSO||9 mg/mL (23.05 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01807026||Completed||Alzheimer Disease|Healthy Volunteers||Eli Lilly and Company||March 2013||Phase 1|
|NCT01775904||Completed||Healthy Volunteers||Eli Lilly and Company||February 2013||Phase 1|
|NCT01561430||Terminated||Alzheimers Disease||Eli Lilly and Company||March 2012||Phase 1|Phase 2|
|NCT01534273||Completed||Healthy Volunteers||Eli Lilly and Company||February 2012||Phase 1|
|NCT01367262||Completed||Healthy Subjects||Eli Lilly and Company||June 2011||Phase 1|
|NCT01227252||Completed||Alzheimers Disease||Eli Lilly and Company||December 2010||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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