Isotretinoin

Catalog No.S1379 Synonyms: 13-cis retinoic acid

Isotretinoin Chemical Structure

Molecular Weight(MW): 300.44

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

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Biological Activity

Description It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Targets
hydroxylase [1]
In vitro

Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2]

In vivo Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.7 mM)
Water Insoluble
Ethanol Insoluble warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.44
Formula

C20H28O2

CAS No. 4759-48-2
Storage powder
Synonyms 13-cis retinoic acid

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03033303 Recruiting Neuroblastoma Memorial Sloan Kettering Cancer Center January 23, 2017 Phase 2
NCT02795143 Recruiting Toxic Epidermal Necrolysis Massachusetts General Hospital November 2016 --
NCT02620813 Recruiting Acne Vulgaris University of California, Davis October 2015 Phase 4
NCT02771743 Recruiting Newly Diagnosed High Risk Neuroblastoma Samsung Medical Center April 2015 Phase 2
NCT02457520 Recruiting Acne Ranbaxy Inc. January 2015 Phase 4
NCT02855138 Completed Adverse Effects of Medical Drugs Kayseri Education and Research Hospital|Kayseri Erciyes University Faculty of Medicine January 2015 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Hydroxylase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID