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Technical Data
| Formula | C20H28O2 |
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| Molecular Weight | 300.44 | CAS No. | 4759-48-2 | |
| Solubility (25°C)* | In vitro | DMSO | 60 mg/mL (199.7 mM) | |
| Ethanol | 1 mg/mL (3.32 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. | |
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| In vitro | Isotretinoin directly interferes with the development of cranial neural crest cells. [1] Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. [2] | |
| In vivo | Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5] |
Protocol (from reference)
References
Selleck's Isotretinoin (13-cis retinoic acid) has been cited by 8 publications
| Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366] | PubMed: 36012634 |
| Neuronal Differentiation-Related Epigenetic Regulator ZRF1 Has Independent Prognostic Value in Neuroblastoma but Is Functionally Dispensable In Vitro [ Cancers -Basel), 2021, 13(19)4845] | PubMed: 34638328 |
| Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma [ Sci Adv, 2021, 7(43):eabe0834] | PubMed: 34669465 |
| The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis [ Cell Death Dis, 2020, 11(9):773] | PubMed: 32943619 |
| 11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma [ Cell Rep, 2020, 32(12):108171] | PubMed: 32966799 |
| MYT1 Attenuates Neuroblastoma Cell Differentiation by Interacting With the LSD1/CoREST Complex [ Oncogene, 2020, 39(21):4212-4226] | PubMed: 32251364 |
| Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid [ Sci Rep, 2018, 8(1):12960] | PubMed: 30154523 |
| Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain [ Elife, 2016, 5e14713] | PubMed: 27130733 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.