Isoconazole nitrate  Chemical Structure

Isoconazole nitrate Chemical Structure
Molecular Weight: 479.14

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Isoconazole nitrate is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Isoconazole nitrate (Travogen) is an azole antifungal reagent. In a clinic study, a total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1% cream of either isoconazole nitrate (R 15454; Travogen; Travogyn) for 4 weeks. The clinical cure rates for the isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. [1][2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Isoconazole nitrate SDF
Molecular Weight (MW) 479.14


CAS No. 24168-96-5
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 41 mg/mL (85.56 mM)
Ethanol 4 mg/mL (8.34 mM)
Water <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-​[2-​(2,​4-​dichlorophenyl)​-​2-​[(2,​6-​dichlorophenyl)​methoxy]​ethyl]​-1H-​imidazole, nitrate (1:1)

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