Isoconazole nitrate

Catalog No.S2534

Isoconazole nitrate (Travogen) is an azole antifungal reagent.

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In DMSO USD 130 In stock
USD 97 In stock
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Isoconazole nitrate  Chemical Structure

Isoconazole nitrate Chemical Structure
Molecular Weight: 479.14

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Isoconazole nitrate is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Isoconazole nitrate (Travogen) is an azole antifungal reagent. In a clinic study, a total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1% cream of either isoconazole nitrate (R 15454; Travogen; Travogyn) for 4 weeks. The clinical cure rates for the isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. [1][2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Isoconazole nitrate SDF
Molecular Weight (MW) 479.14
Formula

C18H14Cl4N2O.HNO3

CAS No. 24168-96-5
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 41 mg/mL (85 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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