Clomipramine HCl

Synonyms: Anafranil

Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).

Clomipramine HCl  Chemical Structure

Clomipramine HCl Chemical Structure

CAS: 17321-77-6

Selleck's Clomipramine HCl has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.75%
99.75

Clomipramine HCl Related Products

Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).
Targets
5-HT [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04708834 Enrolling by invitation
Obsessive Compulsive Disorder
Biohaven Pharmaceuticals Inc.
March 30 2021 Phase 3
NCT00254735 Completed
Obsessive Compulsive Disorder
AstraZeneca
April 2002 Phase 3

Chemical Information & Solubility

Molecular Weight 351.31 Formula

C19H23ClN2.HCl

CAS No. 17321-77-6 SDF Download Clomipramine HCl SDF
Smiles CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (199.25 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 70 mg/mL

Ethanol : 70 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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