Clindamycin HCl

Licensed by Pfizer Catalog No.S2457

Clindamycin HCl  Chemical Structure

Molecular Weight(MW): 461.44

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Targets
50S ribosomal [1]
In vitro

Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]

In vivo Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. [1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. [2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. [3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. [4]

Protocol

Solubility (25°C)

In vitro DMSO 92 mg/mL (199.37 mM)
Water 92 mg/mL (199.37 mM)
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.44
Formula

C18H33ClN2O5S.HCl

CAS No. 21462-39-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02860845 Recruiting Candidiasis|Vaginosis, Bacterial Laboratorios Ordesa|Clever Instruments S.L. July 2016 Phase 4
NCT02730962 Recruiting Pre-Diabetes University of Minnesota - Clinical and Translational Science Institute June 2016 Phase 2
NCT02782078 Not yet recruiting Staphylococcal Infections Assistance Publique - Hôpitaux de Paris June 2016 --
NCT02809131 Recruiting Sick Sinus Syndrome|Complete Heart Block|Syncope|Chronic Systolic Heart Failure Vanderbilt University|Thomas Jefferson University|The Cooper Health System|Valley Health System|Medtronic April 2016 Phase 3
NCT02721173 Completed Acne Vulgaris All India Institute of Medical Sciences, Bhubaneswar April 2016 Phase 4
NCT02674191 Not yet recruiting Orthodontic Anchorage Procedures Cairo University March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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