Clindamycin HCl Licensed by Pfizer

Catalog No.S2457

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

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Clindamycin HCl  Chemical Structure

Clindamycin HCl Chemical Structure
Molecular Weight: 461.44

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Related Compound Libraries

Clindamycin HCl is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Targets 50S ribosomal [1]
In vitro Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]
In vivo Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. [1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. [2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. [3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. [4]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Batzias GC, et al. Vet J,?005, 170(3), 339-345.

[2] Warrick JM, et al. Vet Ther,?000, 1(1), 5-16.

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Clinical Trial Information( data from, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02782078 Not yet recruiting Staphylococcal Infections Assistance Publique - Hôpitaux de Paris June 2016 --
NCT02730962 Recruiting Pre-Diabetes University of Minnesota - Clinical and Translational Scie  ...more University of Minnesota - Clinical and Translational Science Institute June 2016 Phase 2
NCT02721173 Recruiting Acne Vulgaris All India Institute of Medical Sciences, Bhubaneswar April 2016 Phase 4
NCT02809131 Recruiting Sick Sinus Syndrome|Complete Heart Block|Syncope|Chronic Systolic Heart Failure Vanderbilt University|Thomas Jefferson University|The Coo  ...more Vanderbilt University|Thomas Jefferson University|The Cooper Health System|Valley Health System|Medtronic April 2016 Phase 3
NCT02674191 Not yet recruiting Orthodontic Anchorage Procedures Cairo University March 2016 --

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Chemical Information

Download Clindamycin HCl SDF
Molecular Weight (MW) 461.44


CAS No. 21462-39-5
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 92 mg/mL (199.37 mM)
Water 92 mg/mL (199.37 mM)
Ethanol <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (L-​threo-​α-​D-​galacto-​Octopyranoside, methyl 7-​chloro-​6,​7,​8-​trideoxy-​6-​[[[(2S,​4R)​-​1-​methyl-​4-​propyl-​2-​pyrrolidinyl]​carbonyl]​amino]​-​1-​thio-​, hydrochloride (1:1))

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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