Catalog No.S1294 Synonyms: OPC-13013
Molecular Weight(MW): 369.46
Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
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|Description||Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.|
Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation.  Cilostazol also possesses the ability to inhibit adenosine uptake.  Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation.  Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol . 
|In vitro||DMSO||74 mg/mL (200.29 mM)|
|Ethanol||6 mg/mL warmed (16.23 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03451591||Recruiting||Cerebral Small Vessel Diseases|Stroke Lacunar||University of Edinburgh|British Heart Foundation|University of Nottingham||January 8 2018||Phase 2|Phase 3|
|NCT03480321||Completed||Intermittent Claudication||Genovate Biotechnology Co. Ltd.||March 6 2018||Phase 1|
|NCT03189641||Recruiting||Coronary Artery Disease||JIMRO Co. Ltd.||May 31 2017||Not Applicable|
|NCT03248401||Recruiting||Type 2 Diabetes Mellitus|Carotid Atherosclerosis||Seoul National University Bundang Hospital||September 26 2016||Phase 4|
|NCT01359423||Completed||Claudication||Yonsei University||September 26 2011||Not Applicable|
|NCT03581409||Recruiting||Aneurysm Cerebral|Endovascular Procedures||Seoul National University Hospital|Seoul National University Bundang Hospital||July 23 2018||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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