Catalog No.S1294 Synonyms: OPC-13013
Molecular Weight(MW): 369.46
Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
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|Description||Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.|
Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation.  Cilostazol also possesses the ability to inhibit adenosine uptake.  Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation.  Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol . 
|In vitro||DMSO||74 mg/mL (200.29 mM)|
|Ethanol||6 mg/mL warmed (16.23 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02770274||Recruiting||Peripheral Arterial Disease||Attikon Hospital|University Hospital of Patras||December 2016||Phase 3|
|NCT02983214||Recruiting||Ischemic Stroke|Peripheral Artery Disease|Diabetes Mellitus, Type 2||University of Ioannina||November 2016||Phase 4|
|NCT02933788||Not yet recruiting||Type 2 Diabetes Mellitus||Kangbuk Samsung Hospital|Asan Medical Center||October 2016||Phase 4|
|NCT02829151||Not yet recruiting||Critical Limb Ischemia||Yonsei University||July 2016||Phase 4|
|NCT02481323||Recruiting||Cerebral Small Vessel Diseases|Cognitive Impairment|Stroke||University of Edinburgh|University of Nottingham||October 2015||Phase 2|
|NCT02554721||Recruiting||Healthy||Otsuka Pharmaceutical Co., Ltd.||September 2015||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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