Home Microbiology Antibiotics chemical Cefoselis Sulfate For research use only.

Cefoselis Sulfate

Synonyms: FK 037 Sulfate

Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.

Cefoselis Sulfate Chemical Structure

Cefoselis Sulfate Chemical Structure

CAS: 122841-12-7

Purity & Quality Control

Batch: Purity: 99.62%
99.62

Cefoselis Sulfate Related Products

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Biological Activity

Description Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.
In vitro
In vitro

Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4]
In Vivo
In vivo

Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5]

Chemical Information & Solubility

Molecular Weight 620.64 Formula

C19H22N8O6S2.H2SO4
CAS No. 122841-12-7 SDF Download Cefoselis Sulfate SDF
Smiles CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 5 mg/mL

DMSO : 3 mg/mL ( (4.83 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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