Product Categories

mTOR Inhibitors

mTOR Inhibitors (29)
water-soluble

Cat.No.	Product Name	Information	Product Citations
S1039	Rapamycin (Sirolimus)	Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.	Cancer Cell, 2011, 19(6), 792-804 Cell Res, 2012, 22(6):1003-21 Clin Cancer Res, 2011, 17(22), 7116-7126
S1120	Everolimus (RAD001)	Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.	Cell, 2012, 149(3):656-70 Cancer Cell, 2012, 21(2), 155-167 Clin Cancer Res, 2013, 19(3):598-609
S1009	BEZ235 (NVP-BEZ235)	BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.	Nature, 2012, 487(7408):505-9 Blood, 2011, 118(14), 3911-3921 Cancer Res, 2011, 71(15), 5067-5074
S1555	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR with IC50 of 0.8 nM.	Autophagy, 2012, ahead of print Biochem Pharmacol, 2012, 83(9), 1183-1194 Exp Neurol, 2012, 233(2), 799-806
S1038	PI-103	PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.	Leukemia, 2013, 27(3):650-60 Leukemia, 2012, 26(5):927-33 Biochem Pharmacol, 2012, 83(9), 1183-1194
S8040	GDC-0349	GDC-0349, is a potent and selective ATP-competitive inhibitor of mTOR with K_i of 3.8 nM.
S2811	INK 128 (MLN0128)	INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM.
S2218	PP242	PP242 is a selective mTOR inhibitor with IC50 of 8 nM.	Autophagy, 2012, 8(6), 903-914
S2817	Torin 2	Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.
S2783	AZD2014	AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
S2749	NVP-BGT226	NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM.
S2743	PF-04691502	PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with K_i of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM.
S2699	CH5132799	CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM.
S2696	GDC-0980 (RG7422)	GDC-0980 (RG7422) is a potent, selective inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 5 nM, 27 nM, 7 nM, and 14 nM, and also a mTOR inhibitor with K_i of 17 nM.
S2827	Torin 1	Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
S2689	WAY-600	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
S2661	WYE-125132	WYE-125132 is a highly potent, ATP-competitive and specific mTOR inhibitor with IC50 of 0.19 nM.
S2668	WYE-687	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
S2658	GSK2126458	GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with K_i of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.
S2628	PF-05212384 (PKI-587)	PKI-587 is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively.
S2622	PP-121	PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM.
S2624	OSI-027	OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
S2238	Palomid 529	Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively.
S1523	XL765 (SAR245409)	XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.	Endocrinology, 2013, 154(3):1247-59
S1360	GSK1059615	GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively.	Nature, 2012, 486(7404), 532-536
S1266	WYE-354	WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM.	Mol Cancer Res, 2012, 10(6), 821-833
S1226	Ku-0063794	KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.	Cell Stem Cell, 2012, 10(2):210-7 Circ Res, 2010, 107(10), 1265-1274 J Immunol, 2013, 190(7), 3246-55
S1044	Temsirolimus (Torisel)	Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM.	Autophagy, 2011, 7(2), 176-187 Tuberc Respir Dis (Seoul), 2012, 72(4), 343-351 Mol Genet Metab, 2010, 100(4), 309-315
S1022	Deforolimus (Ridaforolimus)	Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM.	Mol Genet Meta, 2010, 100(4), 309-315

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1039	Rapamycin (Sirolimus)	<1 mg/mL	20 mg/mL	4 mg/mL
S1120	Everolimus (RAD001)	<1 mg/mL	30 mg/mL	7 mg/mL
S1009	BEZ235 (NVP-BEZ235)	<1 mg/mL	1 mg/mL	<1 mg/mL
S1555	AZD8055	2 mg/mL	93 mg/mL	15 mg/mL
S1038	PI-103	<1 mg/mL	24 mg/mL	<1 mg/mL
S8040	GDC-0349	<1 mg/mL	91 mg/mL	6 mg/mL
S2811	INK 128 (MLN0128)	<1 mg/mL	62 mg/mL	2 mg/mL
S2218	PP242	<1 mg/mL	62 mg/mL	18 mg/mL
S2817	Torin 2	<1 mg/mL	22 mg/mL	<1 mg/mL
S2783	AZD2014	<1 mg/mL	38 mg/mL	<1 mg/mL
S2749	NVP-BGT226	<1 mg/mL	30 mg/mL	<1 mg/mL
S2743	PF-04691502	<1 mg/mL	14 mg/mL	<1 mg/mL
S2699	CH5132799	<1 mg/mL	12 mg/mL	<1 mg/mL
S2696	GDC-0980 (RG7422)	<1 mg/mL	20 mg/mL	<1 mg/mL
S2827	Torin 1	<1 mg/mL	2 mg/mL	<1 mg/mL
S2689	WAY-600	<1 mg/mL	22 mg/mL	2 mg/mL
S2661	WYE-125132	<1 mg/mL	104 mg/mL	<1 mg/mL
S2668	WYE-687	<1 mg/mL	0.5 mg/mL	<1 mg/mL
S2658	GSK2126458	<1 mg/mL	101 mg/mL	<1 mg/mL
S2628	PF-05212384 (PKI-587)	<1 mg/mL	2 mg/mL	<1 mg/mL
S2622	PP-121	<1 mg/mL	64 mg/mL	2 mg/mL
S2624	OSI-027	<1 mg/mL	18 mg/mL	<1 mg/mL
S2238	Palomid 529	<1 mg/mL	81 mg/mL	<1 mg/mL
S1523	XL765 (SAR245409)	<1 mg/mL	15 mg/mL	<1 mg/mL
S1360	GSK1059615	<1 mg/mL	2 mg/mL	<1 mg/mL
S1266	WYE-354	<1 mg/mL	99 mg/mL	<1 mg/mL
S1226	Ku-0063794	<1 mg/mL	16 mg/mL	<1 mg/mL
S1044	Temsirolimus (Torisel)	1 mg/mL	75 mg/mL	75 mg/mL
S1022	Deforolimus (Ridaforolimus)	<1 mg/mL	198 mg/mL	<1 mg/mL

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mTOR Inhibitors

mTOR Inhibitors (29)water-soluble

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mTOR Inhibitors (29)
water-soluble