Mammalian target of rapamycin

Cat.No.	Product Name	Added

S1555	AZD8055	Oct 2010
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.

S1009	BEZ235 (NVP-BEZ235)	Apr 2009
BEZ235 (NVP-BEZ235) is a dual ATP-competitive phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor with an IC50 of 4, 5, 7 and 75 nM for p110α, p110γ, p110δ and p110β, respectively.

S2406	Chrysophanic acid (Chrysophanol)	Mar 2011
Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.

S1022	Deforolimus (Ridaforolimus)	Apr 2009
Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR.

S1120	Everolimus (RAD001)	Sep 2009
Everolimus (RAD001) also known as SDZ-RAD, Certican, Zortress, Afinitorm is MTOR inhibitor available at Selleck with IC50 of 0.63 nM.

S2696	GDC-0980 (RG7422)	Nov 2011
GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively.

S1360	GSK1059615	Jun 2010
GSK1059615 is a pan-PI3K reversible inhibitor,IC50:PI3Kα(0.4 nM), β (0.6 nM),γ (5 nM),δ (2 nM) and mTOR(12 nM).

S2658	GSK2126458	Aug 2011
GSK2126458 is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K.

S1226	KU-0063794	May 2010
Ku-0063794 is a mTOR inhibitor, IC50 ~10 nM for mTORC1 and mTORC2, respectively.

S2638	NU7441	Aug 2011
NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 μM for DNA-PK, mTOR and PI 3-K, respectively.

S2624	OSI-027	Jun 2011
OSI027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor.

S2238	Palomid 529 (P529)	May 2011
Palomid 529 (P529) is a novel potent antitumour PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel.

S2743	PF-04691502	Jan 2012
PF-04691502 is a potent and selective dual PI3K/mTOR inhibitor to phosphorylation of AKT T308 and AKT S473 with IC50 of 7.5 and 3.8 nM, respectively.

S1038	PI-103	Apr 2009
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.

S2628	PKI-587	Jul 2011
PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively.

S2218	PP242	Apr 2011
PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM.

S1039	Rapamycin (Sirolimus)	Apr 2009
Rapamycin also known as Sirolimus & Rapamune is a mTOR inhibitor. Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated pathways.

S1044	Temsirolimus (Torisel)	Apr 2009
Temsirolimus (Torisel) is a mTOR inhibitor.

S2689	WAY-600	Aug 2011
WAY-600 is a potent ATP-competitive mTOR inhibitor with an IC50 of 9 nM.

S2661	WYE-125132	Aug 2011
WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM.

S1266	WYE-354	Jun 2010
WYE-354 is a mTOR inhibitor with an IC50 of 5 nM.

S2668	WYE-687	Aug 2011
WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM.

S1523	XL765	Oct 2010
XL765 is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively.