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Sirtuin Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7792 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis and is currently in Phase 2.
Cancer Gene Ther, 2025, 32(3):343-354
Chin Med, 2025, 20(1):142
Sci Rep, 2025, 15(1):21283
S8627 OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. This compound has anti-viral effect in HBV transcription and replication.
Front Immunol, 2024, 15:1402834
Sci Rep, 2024, 14(1):30924
Antioxidants (Basel), 2023, 12(3)714
S7845 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Cell Death Differ, 2025, 32(9):1679-1690
Biochemistry, 2023, 10.1021/acs.biochem.3c00381
Front Cell Infect Microbiol, 2022, 12:1031814
S8270 SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(7):167915
Cell Death Dis, 2023, 14(10):667
J Bone Res, 2023, 11(4)1000235
S8245 Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Cell Rep, 2024, 43(9):114728
Int J Mol Sci, 2023, 24(5)4912
Biochemistry, 2023, 10.1021/acs.biochem.3c00381
S9903 NRD167

NRD167 is a potent and selective SIRT5 inhibitor.
Cell Commun Signal, 2025, 23(1):26
PLoS Pathog, 2025, 21(5):e1013163
Cell Rep, 2024, 43(12):115060
S4735 Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
World J Emerg Med, 2024, 15(3):206-213
Cell Transplant, 2023, 32:9636897231198167
Stem Cell Res Ther, 2021, 12(1):507
S8481 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
Cell Rep, 2025, 44(5):115572
Lipids Health Dis, 2025, 24(1):14
Neuro Oncol, 2021, 23(1):53-62
S8909 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM, induces a time-dependent activation of autophagy in several human tumor cell lines.
Cell Death Discov, 2022, 8(1):96
Aging (Albany NY), 2022, 14(23):9730-9757
Molecules, 2022, 27-175641
S8460 Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, this compound is even more efficient at inhibiting Sirt2.
Cancer Lett, 2020, 501:20-30
Am J Transl Res, 2019, 11(8):4789-4799
J Proteome Res, 2018, 17(4):1436-1451
S5914 AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
Front Mol Neurosci, 2024, 17:1394886
Int J Mol Sci, 2023, 24(5)4912
Cell Rep, 2022, 40(2):111062
E8162 Nicotinamide riboside Nicotinamide riboside is an orally active NAD(+) precursor essential for cellular energy and metabolic functions. It Supplementation increases NAD(+) levels, activating sirtuins like SIRT1 and SIRT3, which improve oxidative metabolism and provide protection against metabolic issues induced by a high-fat diet. It also helps to reduce cognitive decline in a transgenic mouse model of Alzheimer's disease.
Gut Microbes, 2025, 17(1):2467193
bioRxiv, 2025, 2025.07.28.667284
S6744 Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.
Front Cell Infect Microbiol, 2022, 12:1031814
Cancer Lett, 2020, 501:20-30
S5918 CAY10602 CAY10602 is a potent SIRT1 activator.
J Med Chem, 2020, 31
S3262 Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
E1150 SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. This compound prevents tumor progression by increasing p53 stability through acetylation at K373/382. It promotes apoptosis through caspase pathway.
E5988New SKLB-11A SKLB-11A is a selective, first-in-class allosteric activator of SIRT3 that binds with a Kd of 4.7 μM and enhances its deacetylase activity with EC50 of 21.95 μM. It improves cardiac function and alleviates myocardial damage in vivo.
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells.
E0394 YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
E5907New 2-APQC 2-APQC is a potent activator of SIRT3 with a Kd value of 2.756 μM. It alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis, exhibiting promising cardioprotective potential in vitro and in vivo. It may serve as a potential candidate for future heart failure (HF) therapeutics.
S6880 SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. This compound reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
E6635 New MC3138 MC3138 is a selective activator of SIRT5 and inhibits proliferation in SIRT5-low PDAC cell lines and organoids by restoring SIRT5-mediated desuccinylation and deacetylation.
E1267 MDL-800 MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.
S2347 Quercetin Dihydrate Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Nucleic Acids Res, 2021, gkab538
Front Immunol, 2021, 12:649285
Verified customer review of Quercetin Dihydrate
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
J Pharm Biomed Anal, 2021, 201:114121
J Transl Med, 2019, 17(1):76
Int J Mol Med, 2019, 44(3):1091-1105
Verified customer review of Tenovin-1
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2.
Cell Death Dis, 2023, 14(10):667
Front Immunol, 2021, 12:685523
Biomed Pharmacother, 2020, 125:109948
S8942 Suramin sodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
Biol Pharm Bull, 2025, 48(5):657-671
J Biol Chem, 2024, S0021-9258(24)00128-5
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493