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ROS Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S8978 MitoQ (Mitoquinone) Mesylate MitoQ (Mitoquinone) mesylate is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.
Cancer Cell, 2025, 43(1):69-85.e11
Sci Adv, 2025, 11(35):eadw9952
bioRxiv, 2025, 2025.02.19.639120
S1630 Allopurinol Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
Biomaterials, 2023, 23(4)
J Exp Clin Cancer Res, 2023, 42(1):249
eNeuro, 2023, 10(10)ENEURO.0159-23.2023
S1547 Febuxostat Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.
Life Sci Alliance, 2025, 8(8)e202403191
Toxicol Sci, 2022, kfac073
J Proteome Res, 2021, 20(6):3134-3149
Verified customer review of Febuxostat
S4603 Gallic acid Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.
iScience, 2024, 27(10):110862
Sci Rep, 2024, 14(1):14907
Sci Rep, 2024, 14(1):12971
S1631 Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
eNeuro, 2023, 10(10)ENEURO.0159-23.2023
bioRxiv, 2023, 10.1101/2023.03.01.530588
J Reprod Immunol, 2021, 149:103457
S3631 (S)-Methylisothiourea sulfate (S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).
Free Radic Biol Med, 2025, 237:631-649
J Pharmacol Exp Ther, 2025, 392(7):103620
Sci Rep, 2024, 14(1):23988
S2369 Troxerutin Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. This compound, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
J Immunother Cancer, 2024, 12(11)e009805
Food Funct, 2019, 10(8):5059-5069
S3616 Asiaticoside Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.
Med Sci Monit, 2020, 26:e924435
S3578 Pyrroloquinoline quinone Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. This compound prevents estrogen deficiency-induced osteoporosis. It can alleviate allergic airway inflammation in mice by improving the immune microenvironment and regulating the JAK-STAT signaling pathway. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Aging Cell, 2025, e70050.
S4017 Allylthiourea Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
S4853 Ecabet sodium Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. This compound inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8, and it can also reduce apoptosis.
S3816 Dehydroevodiamine Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. This compound inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
S3973 L-SelenoMethionine L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
S9107 Glycitein Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
S1623 N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) Acetylcysteine (N-acetyl-l-cysteine, NAC,N-acetylcysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared.
Signal Transduct Target Ther, 2025, 10(1):341
J Exp Med, 2025, 222(3)e20241248
Adv Sci (Weinh), 2025, 12(36):e06150
Verified customer review of N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine)
S7171 Setanaxib (GKT137831) Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. This compound suppresses reactive oxygen species (ROS) production and partly inhibits ferroptosis.
Immunity, 2025, S1074-7613(25)00069-X
Int J Biol Sci, 2025, 21(5):2313-2329
Immunity, 2024, 57(1):52-67.e10
Verified customer review of Setanaxib (GKT137831)
S8639 DPI (Diphenyleneiodonium chloride) Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. It also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).
Redox Biol, 2025, 80:103485
Sci Adv, 2025, 11(34):eadv6937
Exp Mol Med, 2024, 56(12):2602-2616
S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. This compound is also an inhibitor of histone deacetylase (HDAC) and NF-κB. It increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). It induces cell cycle arrest and apoptosis.
J Clin Invest, 2025, 135(14)e176655
Sci Rep, 2025, 15(1):21271
BMC Cancer, 2025, 25(1):1050
S8974 GSK2795039 GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. This compound inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.
Phytomedicine, 2024, 136:156283
Open Med (Wars), 2024, 19(1):20240898
Int J Mol Sci, 2023, 24(18)14369
S6281 Sodium Thiocyanate Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.
Evid Based Complement Alternat Med, 2022, 2022:8315503
E1961 NVL-655 (Neladalkib) NVL-655 is a selective inhibitor of anaplastic lymphoma kinase (ALK), with potential antineoplastic activity in the Ba/F3 xenograft model. It also exhibits significant inhibitory activity against ROS1, LTK, PYK2, TRKB, and FAK, with an IC50 ≤10-fold ALK and demonstrates high potency against specific ALK mutations, with an IC50 of <0.73 nM, 7 nM, 3 nM, 3 nM for G1202R, G1202R/L1196M, G1202R/G1269A and G1202R/L1198F respectively.
Pharm Res, 2025, 42(9):1497-1509
S3205 Perillaldehyde Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.
Front Cell Dev Biol, 2025, 13:1598520
S3590 Triolein Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.
S0947 Cafestol Cafestol is a natural diterpenes extracted from coffee beans. It induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. This compound inhibits the PI3K/Akt pathway and can also reduce the production of ROS in the leukemia cell line HL60.
E1508 APG-2449 APG-2449 is an orally active inhibitor of ALK/ROS1/FAK. This compound exerts potent and durable antitumor activity in human non-small-cell lung cancer (NSCLC) and ovarian tumor models.
S6920 SEA0400 SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. This compound prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.