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ROS Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S4263 Efaproxiral Sodium Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. This compound is used for brain metastases originating from breast cancer.
S4419 Ensulizole Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. This compound can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.
S5804 N-Acetylcysteine amide (NACA) N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
Pharmacol Res, 2025, 219:107902
iScience, 2025, 28(3):111964
Pharmacol Res Perspect, 2025, 13(3):e70120
S2399 Dihydromyricetin Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
Front Pharmacol, 2022, 13:932092
Molecules, 2021, 26(5)1210
Cell Signal, 2020, 65:109431
Verified customer review of Dihydromyricetin
S3301 Cynarin Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. This compound blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. It triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.
Int J Mol Med, 2025, 56(6)206
E7174 D-α-Tocopherol Succinate D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect.