VRAC

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT

Cat.No.	Product Name	Information	Product Use Citations
E0369	Endovion (NS 3728)	Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).
E0001	DCPIB	DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). This compound potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. It displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1/TRAAK channels. This chemical is also a novel selective blocker of I(Cl,swell), which blocks native I(Cl,swell) of calf bovine pulmonary artery endothelial (CPAE) cells with an IC(50) of 4.1 μM.	Journal of Leukocyte Biology, 2025, qiaf006
S2955	NS1652	NS1652 is a reversible chloride channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 μM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 μM) in HEK293 cells.