| S7242 |
Erastin
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Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared.
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Exp Cell Res, 2026, 454(1):114825
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Nature, 2025, 10.1038/s41586-025-09741-1
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Cell, 2025, S0092-8674(25)00751-2
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| S3544 |
VBIT-4
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VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.
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Cell Rep, 2025, 44(5):115605
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Cell Rep, 2025, 44(6):115834
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Aging Cell, 2025, 24(9):e70135
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| S8936 |
VBIT-12
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VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.
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PLoS Pathog, 2025, 21(1):e1012872
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Heliyon, 2024, 10(1):e23426
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Exp Cell Res, 2024, 434(2):113874
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| S0231 |
NSC15364
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NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.
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Exp Cell Res, 2024, 434(2):113874
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| E5770 |
DIDS sodium salt
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