Home Transmembrane Transporters VDAC inhibitor VBIT-12 For research use only.

VBIT-12

VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.

VBIT-12 Chemical Structure

VBIT-12 Chemical Structure

CAS: 2089227-65-4

Selleck's VBIT-12 has been cited by 6 publications

Purity & Quality Control

Batch: S893601 DMSO] 83 mg/mL] false] Water] 2 mg/mL] false] Ethanol] Insoluble] false Purity: 98.69%
98.69

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Biological Activity

Description VBIT-12 is a potent inhibitor of Voltage-dependent anion-selective channel 1 (VDAC1), directly interacting with purified VDAC1, reducing its channel conductance and preventing VDAC1 oligomerization.
Targets
VDAC1 [1]
In vitro
In vitro

VBIT-12 directly interacts with purified VDAC1 and reduces its channel conductance. VBIT-12 interferes with VDAC1 oligomerization and thus with the pro-apoptotic action of VDAC1 when the levels of expression are abnormal, but have no effect on cells under physiological conditions.[2]
In Vivo
In vivo

The effect of VBIT-12 on induction of startle habituation and prepulse inhibition (PPI) in animals is examined via novelty suppressed feeding test, sweet preference model of anhedonia and forced swim test (FST) model for despair. VBIT-12 interacts with the Voltage-Dependent Anion Channel (VDAC) and can be used for the treatment of central nervous system (CNS) disorders and diseases.[1]
Animal Research Animal Models male 129 SVE adult mice, male BALB/c mice aged 8 weeks
Dosages 20 mg/kg
Administration Oral gavage

Chemical Information & Solubility

Molecular Weight 417.50 Formula

C25H27N3O3
CAS No. 2089227-65-4 SDF --
Smiles C1CN(CCC1(C(=O)NCC(=O)O)NC2=CC=CC=C2)CC3=CC=CC4=CC=CC=C43
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 83 mg/mL ( (198.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 2 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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