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Thioredoxin Reductase Inhibitors

Isoform-selective Products

Thioredoxin Reductase Products

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Cat.No. Product Name Information Product Use Citations Product Validations
S4307 Auranofin Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. This compound has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. It is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Cell, 2025, S0092-8674(25)00751-2
Antimicrob Agents Chemother, 2025, e0047125.
Cancers (Basel), 2024, 16(21)3606
S0267 TRi-1 TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. This compound exhibits anti-cancer activity while having little mitochondrial toxicity.
Antimicrob Agents Chemother, 2025, e0047125.
Int J Mol Sci, 2023, 24(15)12460
Oxid Med Cell Longev, 2022, 2022:7067623
F1144 TXNRD1 Antibody [D10G24] TRXR1,TXNRD1
S8068 Chaetocin Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).
Research (Wash D C), 2025, 8:0602
Cell Rep, 2025, 44(6):115742
Int J Mol Sci, 2024, 25(17)9215
S4307 Auranofin Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. This compound has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. It is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Cell, 2025, S0092-8674(25)00751-2
Antimicrob Agents Chemother, 2025, e0047125.
Cancers (Basel), 2024, 16(21)3606
S0267 TRi-1 TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. This compound exhibits anti-cancer activity while having little mitochondrial toxicity.
Antimicrob Agents Chemother, 2025, e0047125.
Int J Mol Sci, 2023, 24(15)12460
Oxid Med Cell Longev, 2022, 2022:7067623
S8068 Chaetocin Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).
Research (Wash D C), 2025, 8:0602
Cell Rep, 2025, 44(6):115742
Int J Mol Sci, 2024, 25(17)9215