Thioredoxin Reductase

Metabolism

DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase Hydroxylase Liver X Receptor FAAH Acyltransferase Dehydrogenase Phosphorylase PPAR CYP17 CETP FXR HMG-CoA Reductase Transferase IDO/TDO Retinoid Receptor Casein Kinase NAMPT phosphatase Lipoxygenase Thioredoxin Decarboxylase Vitamin Serine/threonin kinase LDL Fatty Acid Synthase FOX Glycogen synthesis PKM Glycolysis HDL Carbohydrate Metabolism ATP-citrate lyase Acetyl-CoA carboxylase CYP450 PCSK9 Leukotriene PDHK PGC-1α ROR FABP Peroxidases Aldose Reductase Xanthine Oxidase THR Epoxide Hydrolase PEP GTPCH FAO PAI-1 LDH SCD PREP CPSase Mannosidase Thioredoxin Reductase SGK FTase γGCS CPT SREBP Mitochondrial Metabolism PARG Glucosylceramide Synthase Catalase 3-MST Serine hydrolase CAR glucocerebrosidase Mitochondrial pyruvate carrier GOT SHIP SOD LCN Endogenous Metabolite ATGL NMT Aconitase AGEs Amino Acids and Derivatives Amylase Drug Metabolite Glucokinase Glucosidase glycosidase GSNOR GST Hexokinase Isocitrate Dehydrogenase (IDH) Lipid Liposome LPL Receptor MAGL NEDD4-1 NPC1L1 PGK1 Reductase stilbene oxidase UGT

Isoform-selective Products

TrxR

All (4)
Thioredoxin Reductase Inhibitors (4)
New Thioredoxin Reductase Products

Cat.No.	Product Name	Information	Product Use Citations
S4307	Auranofin (SKF-39162)	Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.	Cell, 2025, S0092-8674(25)00751-2 Antimicrob Agents Chemother, 2025, e0047125. Cancers (Basel), 2024, 16(21)3606
S0267	TRi-1	TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. This compound exhibits anti-cancer activity while having little mitochondrial toxicity.	Antimicrob Agents Chemother, 2025, e0047125. Int J Mol Sci, 2023, 24(15)12460 Oxid Med Cell Longev, 2022, 2022:7067623
S1692	Busulfan	Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia.	Biomolecules, 2025, 15(2)297 J Immunother Cancer, 2024, 12(11)e009805 iScience, 2024, 27(10):110862
S8068	Chaetocin	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	Research (Wash D C), 2025, 8:0602 Cell Rep, 2025, 44(6):115742 Int J Mol Sci, 2024, 25(17)9215
S4307	Auranofin (SKF-39162)	Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.	Cell, 2025, S0092-8674(25)00751-2 Antimicrob Agents Chemother, 2025, e0047125. Cancers (Basel), 2024, 16(21)3606
S0267	TRi-1	TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. This compound exhibits anti-cancer activity while having little mitochondrial toxicity.	Antimicrob Agents Chemother, 2025, e0047125. Int J Mol Sci, 2023, 24(15)12460 Oxid Med Cell Longev, 2022, 2022:7067623
S1692	Busulfan	Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia.	Biomolecules, 2025, 15(2)297 J Immunother Cancer, 2024, 12(11)e009805 iScience, 2024, 27(10):110862
S8068	Chaetocin	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	Research (Wash D C), 2025, 8:0602 Cell Rep, 2025, 44(6):115742 Int J Mol Sci, 2024, 25(17)9215