SIK

Isoform-selective Products

SIK Products

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  • SIK Inhibitors (5)
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Catalog No. Product Name Information Product Use Citations Product Validations
S7565 WH-4-023 WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Nat Commun, 2024, 15(1):668
Cell Stem Cell, 2023, 30(9):1235-1245.e6
Protein Cell, 2023, 14(5):337-349
S9646 YKL-05-099 YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.
Oncogenesis, 2022, 11(1):18
Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S8543 ARN-3236 ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.
Int J Biol Sci, 2024, 20(1):312-330
Mol Oncol, 2022, 16(13):2558-2574
S8393 HG-9-91-01 HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective inhibitor of salt-inducible kinase (SIK) with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3, respectively.
bioRxiv, 2023, 10.1101/2023.04.05.535731
Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S0051 YKL 06-061 YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
S7565 WH-4-023 WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Nat Commun, 2024, 15(1):668
Cell Stem Cell, 2023, 30(9):1235-1245.e6
Protein Cell, 2023, 14(5):337-349
S9646 YKL-05-099 YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.
Oncogenesis, 2022, 11(1):18
Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S8543 ARN-3236 ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.
Int J Biol Sci, 2024, 20(1):312-330
Mol Oncol, 2022, 16(13):2558-2574
S8393 HG-9-91-01 HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective inhibitor of salt-inducible kinase (SIK) with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3, respectively.
bioRxiv, 2023, 10.1101/2023.04.05.535731
Int J Hematol, 2020, 10.1007/s12185-020-03026-1
S0051 YKL 06-061 YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.

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Tags: SIK inhibitor|SIK agonist|SIK activator|SIK inducer|SIK antagonist|SIK signaling pathway|SIK assay kit