SIK

Inhibitory Selectivity

SIK Products

Catalog No. Information Product Use Citations Product Validations
S7565

WH-4-023

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

S0051New

YKL 06-061

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.

S8543New

ARN-3236

ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.

S8393New

HG-9-91-01 (SIK inhibitor 1)

HG-9-91-01 is a potent and highly selective inhibitor of SIK1, SIK2 and SIK3, with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM, respectively.

Catalog No. Information Product Use Citations Product Validations
S7565

WH-4-023

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.

S0051New

YKL 06-061

YKL 06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.

S8543New

ARN-3236

ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.

S8393New

HG-9-91-01 (SIK inhibitor 1)

HG-9-91-01 is a potent and highly selective inhibitor of SIK1, SIK2 and SIK3, with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM, respectively.