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Formula |
C18H18N4
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Molecular Weight | 290.36 | CAS No. | 55778-02-4 | ||||
Solubility (25°C)* | In vitro | DMSO | 30 mg/mL (103.32 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. | ||
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Targets |
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In vitro | WZ811 is a highly potent competitive antagonist of CXCR4. WZ811 is effective in counteracting SDF-1 on cAMP reduction at doses as low as a few nanomoles. WZ811 blocks SDF-1-mediated invasion with EC50 of 5.2 nM. [1] |
, , Invest New Drugs, 2017, 35(6):718-732
Data independently produced by , , Dr.Milica Pesic from Institute for Biological Research
Data independently produced by , , Dr. Milica Pesic from Institute for Biological Research
,
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] | PubMed: 37848438 |
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] | PubMed: 37848438 |
Berbamine targets cancer stem cells and reverses cabazitaxel resistance via inhibiting IGF2BP1 and p-STAT3 in prostate cancer [ Prostate, 2023, 10.1002/pros.24632] | PubMed: 37828768 |
The CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration [ J Genet Genomics, 2022, S1673-8527(22)00125-4] | PubMed: 35483564 |
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells [ Nat Commun, 2021, 12(1):652] | PubMed: 33510160 |
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment [ Cell Rep, 2020, 33(1):108221] | PubMed: 33027668 |
Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis [ Cell Death Dis, 2019, 10(9):648] | PubMed: 31501415 |
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors [ Cell Death Discov, 2019, 5:87] | PubMed: 30993013 |
CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance [Hu X Cancer Lett, 2018, 425:1-12] | PubMed: 29574276 |
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis [Li X Am J Physiol Lung Cell Mol Physiol, 2018, 315(3):L404-L421] | PubMed: 29722562 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.