WZ811

Catalog No.S2912 Batch:S291201

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Technical Data

Formula

 

C18H18N4
 
Molecular Weight 290.36 CAS No. 55778-02-4
Solubility (25°C)* In vitro DMSO 30 mg/mL (103.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
1.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.
Targets
CXCR4 [1]
0.3 nM(EC50)
In vitro WZ811 is a highly potent competitive antagonist of CXCR4. WZ811 is effective in counteracting SDF-1 on cAMP reduction at doses as low as a few nanomoles. WZ811 blocks SDF-1-mediated invasion with EC50 of 5.2 nM. [1]

Protocol (from reference)

Customer Product Validation

, , Invest New Drugs, 2017, 35(6):718-732

Data independently produced by , , Dr.Milica Pesic from Institute for Biological Research

Data independently produced by , , Dr. Milica Pesic from Institute for Biological Research

,

Selleck's WZ811 has been cited by 17 publications

Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] PubMed: 37848438
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] PubMed: 37848438
Berbamine targets cancer stem cells and reverses cabazitaxel resistance via inhibiting IGF2BP1 and p-STAT3 in prostate cancer [ Prostate, 2023, 10.1002/pros.24632] PubMed: 37828768
The CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration [ J Genet Genomics, 2022, S1673-8527(22)00125-4] PubMed: 35483564
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells [ Nat Commun, 2021, 12(1):652] PubMed: 33510160
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment [ Cell Rep, 2020, 33(1):108221] PubMed: 33027668
Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis [ Cell Death Dis, 2019, 10(9):648] PubMed: 31501415
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors [ Cell Death Discov, 2019, 5:87] PubMed: 30993013
CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance [Hu X Cancer Lett, 2018, 425:1-12] PubMed: 29574276
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis [Li X Am J Physiol Lung Cell Mol Physiol, 2018, 315(3):L404-L421] PubMed: 29722562

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.