Home Epigenetics HDAC inhibitor UF010

research use only

UF010 HDAC inhibitor

Cat.No.S5810

UF010 is a class I HDAC-selective inhibitor with IC50 values of 0.5 nM, 0.1 nM, 0.06 nM, 1.5 nM, 9.1 nM and 15.3 nM for HDAC1, HDAC2, HDAC3, HDAC8, HDAC6 and HDAC10, respectively.
UF010 HDAC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 271.15

Jump to

Quality Control

Batch: S581001 DMSO]54 mg/mL]false]Ethanol]54 mg/mL]false]Water]Insoluble]false Purity: 99.58%
99.58

Solubility

In vitro
Batch:

DMSO : 54 mg/mL (199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 54 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 271.15 Formula

C11H15BrN2O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 537672-41-6 -- Storage of Stock Solutions

Synonyms N/A Smiles CCCCNNC(=O)C1=CC=C(C=C1)Br

Mechanism of Action

Targets/IC50/Ki
HDAC3
(Cell-free assay)
0.06 nM
HDAC2
(Cell-free assay)
0.1 nM
HDAC1
(Cell-free assay)
0.5 nM
HDAC8
(Cell-free assay)
1.5 nM
HDAC6
(Cell-free assay)
9.1 nM
HDAC10
(Cell-free assay)
15.3 nM
In vitro
In Cell-cycle analysis using MDA-MB-231 cells, UF010 mainly blocks G1/S transition with an increased G1 cell population and a reduced cell population in the S phase in a dose-dependent manner. This compound has a half-life of 15.8 hr in cell culture medium containing 10% fetal bovine serum.
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map