Trimetazidine dihydrochloride

Catalog No.S4543 Synonyms: Yoshimilon, Kyurinett, Vastarel F

For research use only.

Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.

Trimetazidine dihydrochloride Chemical Structure

CAS No. 13171-25-0

Selleck's Trimetazidine dihydrochloride has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
Targets
mitochondrial long-chain 3-ketoacyl thiolase [1]
(Cell-free assay)
75 nM
In vitro

Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3].

In vivo The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2].

Protocol (from reference)

Cell Research:

[3]

  • Cell lines: human H9C2 cell line
  • Concentrations: 10 μM
  • Incubation Time: 48 h
  • Method:

    The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment.

Animal Research:

[2]

  • Animal Models: C57BL/6J, AMPK KD mice
  • Dosages: 0.5 mg/kg
  • Administration: tail vein injection

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 339.26
Formula

C14H22N2O3.2HCl

CAS No. 13171-25-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl

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