Trimetazidine dihydrochloride

For research use only.

Catalog No.S4543 Synonyms: Yoshimilon, Kyurinett, Vastarel F

1 publication

Trimetazidine dihydrochloride Chemical Structure

CAS No. 13171-25-0

Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.

Selleck's Trimetazidine dihydrochloride has been cited by 1 publication

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Description Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
Targets
mitochondrial long-chain 3-ketoacyl thiolase [1]
(Cell-free assay)
75 nM
In vitro

Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion[3].

In vivo The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia[2].

Protocol

Cell Research:

[3]

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  • Cell lines: human H9C2 cell line
  • Concentrations: 10 μM
  • Incubation Time: 48 h
  • Method:

    The H9C2 cells are randomly assigned into three groups: Sham group, in which the cells are treated with 0μM TMZ for 48 h and then cultured under normal oxygenation conditions (5% CO2, and 95% air); H/R group, in which cells are treated with 0 μM TMZ for 48 h and then cultured under H/R conditions; and H/R+TMZ group, in which cells are treated with 10 μM TMZ for 48 h and then subjected to H/R treatment.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: C57BL/6J, AMPK KD mice
  • Dosages: 0.5 mg/kg
  • Administration: tail vein injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 67 mg/mL warmed (197.48 mM)
Water 67 mg/mL (197.48 mM)
Ethanol 67 mg/mL (197.48 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 339.26
Formula

C14H22N2O3.2HCl

CAS No. 13171-25-0
Storage powder
in solvent
Synonyms Yoshimilon, Kyurinett, Vastarel F
Smiles COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID