CAS No. 1609960-30-6
Batch:
Purity:99.15
Chemical Structure
Check the
TH287
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 1609960-30-6 | |
| Molecular Formula |
C11H10Cl2N4 |
|
| Molecular Weight (MW) | 269.13 | |
| SMILES | CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N | |
| InChIKey | URWCXPXBBITYLR-UHFFFAOYSA-N |
TH287 is a potent and selective MTH1 (NUDT1) inhibitor with an IC50 of. By suppressing MTH1, it impairs the sanitization of oxidized nucleotide pools, leading to the incorporation of damaged nucleotides such as 8-oxo-dGTP into genomic DNA. This accumulation induces double-strand DNA breaks, activates DNA damage response pathways, and ultimately triggers selective cytotoxicity in cancer cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(196.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.