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Safusidenib

Name: Safusidenib
Brand: Selleck Chemicals
SKU: E6534
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6534

Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective inhibitor of mutant IDH1. It demonstrates potent inhibition against mutant IDH1 while showing minimal activity against the wild-type enzyme. This compound exhibits antitumor effects in chondrosarcoma models. In vitro assays without preincubation, it inhibits IDH1R132H and IDH1R132C with IC50 values of 15 nM and 130 nM, respectively.

Chemical Structure

Molecular Weight: 535.78

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SDS
Datasheet

Related Targets	PROTAC Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Hydrotropic Agents Antibiotics for Plant Cell Culture
Other Others Inhibitors	Furimazine (PBI 3939) BAY 2927088（Sevabertinib） Guanidinoacetic acid BAPTA-AM Blebbistatin Silibinin (NSC 651520) Polybrene (Hexadimethrine Bromide) Carbazochrome sodium sulfonate (AC-17) Palmitic acid Osthole

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Mass	Concentration	Volume	Molecular Weight
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Chemical Information, Storage & Stability

Molecular Weight	535.78	Formula	C25H18Cl3FN2O4	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1898206-17-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AB-291; DS-1001			Smiles	O=C(N1C2=CC=CC(/C=C/C(O)=O)=C2C(C)=C1)C3=C(C(C)(F)C)ON=C3C4=C(C=C(C=C4Cl)Cl)Cl

Mechanism of Action

In vivo	Safusidenib (DS-1001b) has antineoplastic activity in JJ012 xenografts. Continuous administration of this compound (mixed with sterilized pellet food and fed continuously for 6 weeks) impairs tumor growth in xenograft mice.
References	[1] https://pubmed.ncbi.nlm.nih.gov/31406254/ [2] https://pubmed.ncbi.nlm.nih.gov/31727689/

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