CAS No. 979-92-0
| IUPAC Name | (2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid | |
|---|---|---|
| CAS Number | 979-92-0 | |
| Molecular Formula |
C14H20N6O5S |
|
| Molecular Weight (MW) | 384.41 | |
| SMILES | NC(CCSCC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C(O)=O | |
| InChIKey | ZJUKTBDSGOFHSH-WFMPWKQPSA-N |
S-Adenosyl-L-Homocysteine (SAH) is a potent product inhibitor of S-adenosylmethionine-dependent methyltransferases, including the METTL3-METTL14 heterodimer complex. By competing with S-adenosylmethionine, SAH impairs the enzymatic activity of the METTL3-METTL14 complex, suppressing N6-methyladenosine (m6A) RNA modification pathways. This inhibition affects downstream mRNA stability, translation efficiency, and epigenetic gene regulation involved in cellular proliferation and differentiation processes. [1][2]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- S-Adenosyl-L-Homocysteine (SAH) Clinical Trials
- S-Adenosyl-L-Homocysteine (SAH) Solubility in DMSO
- S-Adenosyl-L-Homocysteine (SAH) Storage
- S-Adenosyl-L-Homocysteine (SAH) Stability
- S-Adenosyl-L-Homocysteine (SAH) Molecular Weight
- S-Adenosyl-L-Homocysteine (SAH) SMILES
- S-Adenosyl-L-Homocysteine (SAH) Chemical Structure (2D and 3D)
- S-Adenosyl-L-Homocysteine (SAH) SDS｜MSDS