Rimiducid (AP1903)

For research use only.

Catalog No.S9726

Rimiducid (AP1903) Chemical Structure

CAS No. 195514-63-7

Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM.

Purity & Quality Control

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Biological Activity

Description Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM.
Targets
FKBP fusion protein [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (70.84 mM)
Water Insoluble
Ethanol ''100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1411.63
Formula

C78H98N4O20

CAS No. 195514-63-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03807063 Withdrawn Biological: Rivogenlecleucel|Drug: Rimiducid Acute Bilineal Leukemia|Myelodysplastic/Myeloproliferative Neoplasm|Myelodysplastic/Myeloproliferative Neoplasm Unclassifiable|Myeloproliferative Neoplasm|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Lymphoblastic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm|Recurrent Chronic Lymphocytic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Recurrent Chronic Myelomonocytic Leukemia|Recurrent Myelodysplastic Syndrome Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|Bellicum Pharmaceuticals January 2 2020 Phase 1
NCT02849886 Recruiting Drug: T lymphocytes iCASP9 ΔCD19|Drug: Dimerizer drug AP1903 Graft Versus Host Disease|Hematological Malignancies Centre Hospitalier Universitaire de Besancon|Etablissement Français du Sang|Bellicum Pharmaceuticals April 10 2019 Phase 1|Phase 2
NCT03741127 Enrolling by invitation Drug: Rimiducid may be administered as indicated Multiple Myeloma Poseida Therapeutics Inc.|California Institute for Regenerative Medicine (CIRM) October 29 2018 Phase 1
NCT03733249 Enrolling by invitation Drug: Rimiducid|Biological: rivogenlecleucel Acute Lymphoblastic Leukemia|Leukemia Acute Myeloid (AML) Child|Lymphoma Non-Hodgkin|Myelodysplastic Syndromes|Primary Immunodeficiency|Anemia Aplastic|Hemoglobinopathies|Cytopenia|Fanconi Anemia|Diamond Blackfan Anemia|Thalassemia|Anemia Sickle Cell Bellicum Pharmaceuticals January 2017 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID