Raloxifene

Catalog No.S5781 Synonyms: Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129

For research use only.

Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.

Raloxifene Chemical Structure

CAS No. 84449-90-1

Selleck's Raloxifene has been cited by 2 Publications

Purity & Quality Control

Choose Selective Estrogen/progestogen Receptor Inhibitors

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Biological Activity

Description Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.
Targets
ER [1]
(Cell-free assay)
5.7 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 473.58
Formula

C28H27NO4S

CAS No. 84449-90-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01973738 Unknown status -- Selective Estrogen Receptor Modulator Toshihiko Kono|Tomidahama Hospital January 2012 --
NCT02977949 Unknown status Drug: Raloxifene Selective Estrogen Receptor Modulator (SERM) Toshihiko Kono|Tomidahama Hospital January 2012 --
NCT01573637 Completed Drug: Raloxifene|Drug: Lactosa (placebo arm) Negative Symptoms of Schizophrenia in Post-menopausal Women. Fundació Sant Joan de Déu|Hospital Sant Joan de Deu|Parc Sanitari Sant Joan de Déu|Stanley Medical Research Institute July 2011 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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