Pyridostatin (RR82) Trifluoroacetate Salt

For research use only.

Catalog No.S7444

7 publications

Pyridostatin (RR82) Trifluoroacetate Salt Chemical Structure

CAS No. 1472611-44-1

Pyridostatin Trifluoroacetate Salt (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.

Selleck's Pyridostatin (RR82) Trifluoroacetate Salt has been cited by 7 publications

Purity & Quality Control

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Biological Activity

Description Pyridostatin Trifluoroacetate Salt (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.
Targets
G-quadruplexe [1]
(Cell-free assay)
490 nM(Kd)
In vitro

Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC. [2] Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MRC5 NGjOeo1EgXSxdH;4bYNqfHliYYPzZZk> M{nJZVczKGi{cx?= NInHPINEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOWkN3IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME21MlM5|ryPLh?= NGf1ZYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUOyN|Q6OSd-MkmzNlM1QTF:L3G+
KB-3-1 MojndWhVWyCjc4PhfS=> MWLQMYdtgWOxcILveIVqdiC|dXLzeJJifGW|IHnk[Y51cW[rZXSgbY4hU0JvMz2xJIFl\W6xY3HyZ4lvd22jIHPlcIwhdGmwZTygdWhVWyC2aHXyZZBmfXSrYzDsbYJz[XK7IIPjdoVmdg>? MoraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MUWyPFQoRjNzNUG1Nlg1RC:jPh?=

... Click to View More Cell Line Experimental Data

In vivo

Protocol

Cell Research:

[2]

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  • Cell lines: MRC-5–SV40 cells and various cancer cell lines
  • Concentrations: 10 μM
  • Incubation Time: 48 h
  • Method:

    Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (140.7 mM)
Water 100 mg/mL (140.7 mM)
Ethanol ''''30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 710.7
Formula

C31H32N8O5·C2HF3O2

CAS No. 1472611-44-1
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.C(=O)(C(F)(F)F)O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID