Pyridostatin Trifluoroacetate Salt

Catalog No.S7444

Pyridostatin Trifluoroacetate Salt Chemical Structure

Molecular Weight(MW): 596.64(free base basis)

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

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Description Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
Targets
G-quadruplexe [1]
(Cell-free assay)
490 nM(Kd)
In vitro

Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC. [2] Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes. [3]

Protocol

Cell Research:[2]
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  • Cell lines: MRC-5–SV40 cells and various cancer cell lines
  • Concentrations: 10 μM
  • Incubation Time: 48 h
  • Method: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL
Water 100 mg/mL
Ethanol 30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 596.64(free base basis)
Formula

C31H32N8O5·xC2HF3O2

CAS No. 1085412-37-8(free base)
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID