CAS No. 1370261-96-3
Batch:
Purity:99.33
Chemical Structure
Check the
PRT062607
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 1370261-96-3 | |
| Molecular Formula |
C19H23N9O |
|
| Molecular Weight (MW) | 393.45 | |
| InChIKey | TXGKRVFSSHPBAJ-JKSUJKDBSA-N |
PRT062607 is a potent, selective, and orally bioavailable inhibitor of spleen tyrosine kinase (SYK) with an IC50 of 1-2 nM. It blocks B-cell receptor and Fc receptor-mediated signaling pathways, inhibiting downstream phosphorylation events. This suppression impairs B-cell activation, mast cell degranulation, and pro-inflammatory cytokine release, demonstrating significant anti-inflammatory activity in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.