Home Apoptosis Heme Oxygenase inhibitor Protoporphyrin IX Zinc

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Protoporphyrin IX Zinc Heme Oxygenase inhibitor

Cat.No.S7880

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor and significantly reduces the protective effects of Phloroglucinol (PG) against hydrogen peroxide.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Protoporphyrin IX Zinc Heme Oxygenase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 626.04

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Quality Control

Batch: S788001 DMSO]Insoluble]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.90%
98.90

Solubility

In vitro
Batch:

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 626.04 Formula

C34H30N4O4Zn.2H

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 15442-64-5 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
HO-1
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-01-29)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07123363 WITHDRAWN
Protoporphyria
Wake Forest University Health Sciences
 2026-01 PHASE1
NCT07729579 RECRUITING
Actinic Keratosis (AK)
Sun Pharmaceutical Industries Limited
 2026-08-04 PHASE1
NCT05308472 COMPLETED
Erythropoietic Protoporphyria
Disc Medicine, Inc
 2022-10-31 PHASE2
NCT04319159 COMPLETED
Actinic Keratoses
Biofrontera Bioscience GmbH
 2020-03-05 PHASE1
NCT04221126 COMPLETED
Normal Skin
Merete Haedersdal
 2019-04-29 PHASE4
NCT01550705 TERMINATED
Erythropoietic Protoporphyria (EPP); X Linked Erythropoietic Protoporphyria
University of Utah
 2012-03

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