CAS No. 15442-64-5

Batch: Purity:98.90
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Protoporphyrin IX Zinc Chemical Structure
Chemical Structure
Check the Protoporphyrin IX Zinc product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name zinc 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
CAS Number 15442-64-5
Molecular Formula

C34H30N4O4Zn.2H
Molecular Weight (MW) 626.04
InChIKey FUTVBRXUIKZACV-UHFFFAOYSA-L

Biological Activity

Protoporphyrin IX Zinc is a potent, orally active, and competitive heme oxygenase-1 (HO-1) inhibitor. By suppressing HO-1 catalytic activity, it prevents the enzymatic degradation of heme into biliverdin, carbon monoxide, and free iron. This inhibition attenuates cellular antioxidant defense mechanisms, modulates oxidative stress pathways, and sensitizes cells to reactive oxygen species, thereby significantly reducing cytoprotective responses under oxidative stress conditions. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Maines MD. FASEB J. 1988;2(10):2557-68.

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Note: Technical data last updated: Sep 1, 2026.