CAS No. 15442-64-5
| IUPAC Name | zinc 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid | |
|---|---|---|
| CAS Number | 15442-64-5 | |
| Molecular Formula |
C34H30N4O4Zn.2H |
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| Molecular Weight (MW) | 626.04 | |
| InChIKey | FUTVBRXUIKZACV-UHFFFAOYSA-L |
Protoporphyrin IX Zinc is a potent, orally active, and competitive heme oxygenase-1 (HO-1) inhibitor. By suppressing HO-1 catalytic activity, it prevents the enzymatic degradation of heme into biliverdin, carbon monoxide, and free iron. This inhibition attenuates cellular antioxidant defense mechanisms, modulates oxidative stress pathways, and sensitizes cells to reactive oxygen species, thereby significantly reducing cytoprotective responses under oxidative stress conditions. [1]
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Concentration
Volume
Mass
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1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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