Home Protein Tyrosine Kinase c-Kit inhibitor - VEGFR inhibitor - CSF-1R inhibitor - PDGFR inhibitor PDGFR inhibitor 1 For research use only.

PDGFR inhibitor 1

PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.

PDGFR inhibitor 1 Chemical Structure

PDGFR inhibitor 1 Chemical Structure

CAS: 1225278-16-9

Selleck's PDGFR inhibitor 1 has been cited by 2 publications

Purity & Quality Control

Batch: S872101 DMSO] 97 mg/mL] false] Ethanol] 9 mg/mL] false] Water] Insoluble] false Purity: 98.97%
98.97

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Biological Activity

Description PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.
Targets
c-Fms [1] VEGFR2 [1] Kit [1] PDGFR [1]

Chemical Information & Solubility

Molecular Weight 489.47 Formula

C26H21F2N5O3
CAS No. 1225278-16-9 SDF --
Smiles CN1C=C(C=N1)C2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 97 mg/mL ( (198.17 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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