Home Protein Tyrosine Kinase c-Kit inhibitor ISCK03 For research use only.

ISCK03

Synonyms: N-(4-imidazol-1-yl phenyl)sulfonamide

ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide) is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.

ISCK03 Chemical Structure

ISCK03 Chemical Structure

CAS: 945526-43-2

Selleck's ISCK03 has been cited by 2 publications

Purity & Quality Control

Batch: S207001 DMSO] 71 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.76%
99.76

ISCK03 Related Products

Signaling Pathway

c-Kit Signaling Pathways

c-Kit Signaling Pathway

Choose Selective c-Kit Inhibitors

Biological Activity

Description ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide) is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.
Targets
SCF [1] c-Kit [1]

Chemical Information & Solubility

Molecular Weight 355.45 Formula

C19H21N3O2S

 
CAS No. 945526-43-2 SDF --
Smiles CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 71 mg/mL ( (199.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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