CAS No. 501684-93-1
Batch:
Purity:99.92
Chemical Structure
Check the
NS 1738
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 501684-93-1 | |
|---|---|---|
| Molecular Formula |
C14H9Cl2F3N2O2 |
|
| Molecular Weight (MW) | 365.13 | |
| SMILES | C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl |
Biological Activity
NS 1738 is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), enhancing acetylcholine-evoked ion currents at human α7 nAChR and rat α7 nAChR. Activation of α7 nAChR signaling enhances neuronal excitability and synaptic transmission, resulting in downstream pro-cognitive effects and improved sensorimotor gating in animal models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 73 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.