CAS No. 1807454-59-6
Batch:
Purity:99.57
Chemical Structure
Check the
NP-G2-044
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methyl-N-[1-[[4-(trifluoromethyl)phenyl]methyl]indazol-3-yl]furan-3-carboxamide | |
|---|---|---|
| CAS Number | 1807454-59-6 | |
| Molecular Formula |
C21H16F3N3O2 |
|
| Molecular Weight (MW) | 399.37 | |
| SMILES | CC1=C(C=CO1)C(=O)NC2=N[N](CC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C24 | |
| InChIKey | XLLRLAABUFOJPC-UHFFFAOYSA-N |
NP-G2-044 is a potent, orally active small-molecule inhibitor of fascin that specifically targets its actin-bundling activity. By blocking fascin-mediated cross-linking of actin filaments into parallel bundles, NP-G2-044 disrupts filopodia formation and dynamic membrane protrusion. Inhibition of fascin function impairs cancer cell motility and invasion, resulting in blocked tumor metastasis and heightened antitumor immune responses in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 80 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.