GSK269962A HCl

For research use only.

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

4 publications

GSK269962A HCl Chemical Structure

CAS No. 2095432-71-4

GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Selleck's GSK269962A HCl has been cited by 4 publications

Purity & Quality Control

Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NXLRdplzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUW4NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh2N{eg{txO NXTWfpZpW0GQR1XS
NCI-H1694 M1XmU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[5OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1Njh5NEmg{txO M1jrW3NCVkeHUh?=
NCI-H1963 NFjMU2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUm2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd6M{mg{txO NXPvPYNDW0GQR1XS
NCI-H2081 NFPrTWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4XxemlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFgyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwNkC0OEDPxE1? MVPTRW5ITVJ?
NCI-H209 M3uwd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUPaT3VSUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[yO|Ih|ryP NXzhVWxoW0GQR1XS
NCI-H2107 MlroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFrFd2tKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlExPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ3Lk[1OlEh|ryP NV7CPYJDW0GQR1XS
NCI-H2126 M1\mZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4m2XmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi53MESyOkDPxE1? NHK5WGZUSU6JRWK=
NCI-H2171 MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFTyd2RKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUW5N|ch|ryP NH:3bFlUSU6JRWK=
NCI-H2227 M3PCXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoP4TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njh6NkG2JO69VQ>? NE\3SlhUSU6JRWK=
NCI-H524 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4jjNmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi56N{[zJO69VQ>? MlrNV2FPT0WU
NCI-H526 NXLnR5lkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2HMZmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC53NEOxJO69VQ>? MVzTRW5ITVJ?
NCI-H720 NUXUXY0zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XrXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR3MU[xJO69VQ>? MWTTRW5ITVJ?
NMC-G1 NFLBU2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUX5WVF7UW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5yNUe4JO69VQ>? MWHTRW5ITVJ?
NOS-1 cell M3vZXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPaSJlKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45OjJ7NDFOwG0> M1XydXNCVkeHUh?=
OCI-AML2 cell NEfRTZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4q2PWlvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC57NEm2JO69VQ>? M1PpeXNCVkeHUh?=
OCUB-M cell Ml\WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlIxOSEQvF2= NIXJ[4lUSU6JRWK=
ONS-76 cell MkfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4PaVWlvcGmkaYTpc44hd2ZiaIXtZY4hV06VLUe2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQTF7MTFOwG0> NWPTSW9VW0GQR1XS
OS-RC-2 cell M3PNWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnH3TY5pcWKrdHnvckBw\iCqdX3hckBQWy2UQz2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFYvOTl3IN88US=> MoHtV2FPT0WU
OVCAR-4 cell NXHibpRKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlcyQDB6IN88US=> M1zER3NCVkeHUh?=
P30-OHK cell Mn;ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlYzQDd5IN88US=> MUjTRW5ITVJ?
P30-OHK cell NGizUYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWK4XYVpUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB2OUW0JO69VQ>? NGH5SGJUSU6JRWK=
PSN1 cell Mlm1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjHTY5pcWKrdHnvckBw\iCqdX3hckBRW05zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yNlEzPiEQvF2= MULTRW5ITVJ?
QIMR-WIL cell NFn5R4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;JTY5pcWKrdHnvckBw\iCqdX3hckBSUU2ULWfJUEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPDlyMESg{txO NX\OWIFrW0GQR1XS
RCC10RGB cell NGDocJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWTEUVNMUW6qaXLpeIlwdiCxZjDoeY1idiCUQ1OxNHJISiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkmwN|Yh|ryP MXnTRW5ITVJ?
RKO cell NEfFcHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkPVTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OlYzKM7:TR?= MofxV2FPT0WU
RL95-2 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYns[lR7UW6qaXLpeIlwdiCxZjDoeY1idiCUTEm1MVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC54NzFOwG0> MYjTRW5ITVJ?
RPMI-6666 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFTSbpRKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkWyN|Yh|ryP M{HSPHNCVkeHUh?=
RPMI-8402 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHle|lRUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVg1ODJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW4OVYh|ryP MUfTRW5ITVJ?
RXF393 cell NXe5TpFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHGW5lKdmirYnn0bY9vKG:oIHj1cYFvKFK[RkO5N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzl|IN88US=> MmPKV2FPT0WU
Ramos-2G6-4C10 cell NU\JVGppT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlKzTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|U4KM7:TR?= M1jucnNCVkeHUh?=
SCLC-21H cell NIr2[ZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkC0TY5pcWKrdHnvckBw\iCqdX3hckBUS0yFLUKxTEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPjFzNEmg{txO MmjYV2FPT0WU
SF126 cell NF;WOHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2jQXGlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU45OzJzzszN M1r0bHNCVkeHUh?=
SF268 cell M3flOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yN|E5OyEQvF2= Ml;HV2FPT0WU
SF539 cell NVHvPFB2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF61fnBKdmirYnn0bY9vKG:oIHj1cYFvKFOINUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQDZ4MTFOwG0> M3e3Z3NCVkeHUh?=
SH-4 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHe2NXhKdmirYnn0bY9vKG:oIHj1cYFvKFOKLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlc2PTB6IN88US=> NG\wU41USU6JRWK=
SIG-M5 cell M{OzRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlczPTlizszN NWnNeoxyW0GQR1XS
SJSA-1 cell NXvvZXhET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NImwco9KdmirYnn0bY9vKG:oIHj1cYFvKFOMU1GtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODR3Mk[g{txO NVzUcVlXW0GQR1XS
SK-LMS-1 cell MnP1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1r6e2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi53OU[1JO69VQ>? NGjmUohUSU6JRWK=
SK-MM-2 cell M2[xSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfHTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvOzRyNTFOwG0> MWXTRW5ITVJ?
SK-N-DZ cell M{nRT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NID4cItKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjR6M{G0JO69VQ>? MnTxV2FPT0WU
SK-NEP-1 cell NHPOUpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPTR3NjFOwG0> M{D2TnNCVkeHUh?=
SK-PN-DW cell NW\ESHhRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrMOod4UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lkm3N|Yh|ryP MVfTRW5ITVJ?
SNB75 cell NEPT[3VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3XaWmlvcGmkaYTpc44hd2ZiaIXtZY4hW06EN{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4PzN5IN88US=> NIHGeoxUSU6JRWK=
SR cell NVXR[Is1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzOdmtKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFAyOzdizszN NWnXeYExW0GQR1XS
SU-DHL-1 cell NH64fIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzN|NjFOwG0> M1TZc3NCVkeHUh?=
SW684 cell M4DyUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4SzeGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4xOTFizszN M4jEVHNCVkeHUh?=
SW872 cell NXLCXoZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1fHOGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg5PjV4IN88US=> MXXTRW5ITVJ?
SW962 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYOzRVVYUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd3MkGg{txO NXvMbJo4W0GQR1XS
697 cell M3nkUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUHYellpUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI6QTFizszN NWHXXGVpW0GQR1XS
8-MG-BA cell M4[1fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fFO2lvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI{NjB5OUOg{txO MULTRW5ITVJ?
A101D cell MnrpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVjJcohq[mm2aX;uJI9nKGi3bXHuJGEyODGGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64O|A{PCEQvF2= MknWV2FPT0WU
ACN cell M1HaVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mon0TY5pcWKrdHnvckBw\iCqdX3hckBCS05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT60N|g4KM7:TR?= MWnTRW5ITVJ?
AM-38 cell M{XwWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPzZYRKdmirYnn0bY9vKG:oIHj1cYFvKEGPLUO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4zPjN{NzFOwG0> MYrTRW5ITVJ?
ATN-1 cell NHe3UodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4T1e2lvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE44PTV3IN88US=> MYDTRW5ITVJ?
BB30-HNC cell MmTJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjV|MjFOwG0> NVf1T4h1W0GQR1XS
BB49-HNC cell M1PwfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKGi3bXHuJGJDPDlvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODd6OTFOwG0> MWTTRW5ITVJ?
human BC-1 cell M2e4Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lkm3NVA4KM7:TR?= M4HZR3NCVkeHUh?=
BE-13 cell NX7kPHlNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjFdVhuUW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTRyOEJOwG0> MUXTRW5ITVJ?
BL-70 cell MkLaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnO[VRKdmirYnn0bY9vKG:oIHj1cYFvKEKOLUewJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{41ODdyMzFOwG0> M3PkRXNCVkeHUh?=
BV-173 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGJXNTF5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG4Mlg5PTlizszN Mn;OV2FPT0WU
Becker cell NXrle5l5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjRWmV2UW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57NUS1JO69VQ>? M1u0e3NCVkeHUh?=
CAL-148 cell M{X1OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmHyTY5pcWKrdHnvckBw\iCqdX3hckBESUxvMUS4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|UvPjV3NzFOwG0> NXzLe4dMW0GQR1XS
TE-10 cell NYe1U5pjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{nxWWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk45PDJ|IN88US=> NGL6XHZUSU6JRWK=
TE-12 cell M1i1W2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NITCRodKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvPDFzNDFOwG0> M{\ZZ3NCVkeHUh?=
TE-8 cell NW\IdY9bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHYclFKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43ODh7IN88US=> Mne4V2FPT0WU
TE-9 cell MkfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Nj62N|gyKM7:TR?= M1XLenNCVkeHUh?=
TGW cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\5W4RKdmirYnn0bY9vKG:oIHj1cYFvKFSJVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlM2PzdizszN NV3lZnQ3W0GQR1XS
UACC-257 cell NFK5OFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJHVCS0NvMkW3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE44ODZ{NTFOwG0> NFTlTIdUSU6JRWK=
WSU-NHL cell NXrmTXh6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmTMTY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlcvOTlyNzFOwG0> MVfTRW5ITVJ?
no-10 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4LIU2lvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY3QDR4IN88US=> NYnvco1VW0GQR1XS
no-11 cell MmL3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1TH[GlvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{4xOjZ|IN88US=> NITmfIdUSU6JRWK=
CAS-1 cell Ml7DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlewTY5pcWKrdHnvckBw\iCqdX3hckBESVNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ4KM7:TR?= M2exd3NCVkeHUh?=
CCRF-CEM cell NGXjRlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEXNZVdKdmirYnn0bY9vKG:oIHj1cYFvKEOFUl[tR2VOKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54NUO5NkDPxE1? NXrPXW13W0GQR1XS
CMK cell NFPRWGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXvTY5pcWKrdHnvckBw\iCqdX3hckBEVUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCxN|I{KM7:TR?= MYnTRW5ITVJ?
COLO-829 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;BTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiyPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjR{Mk[g{txO MXjTRW5ITVJ?
COR-L279 cell NYj0OnpST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4\lSGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVyyO|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB5M{ig{txO NGDKRXVUSU6JRWK=
CP66-MEL cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJGNRPjZvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvPTR7NzFOwG0> M2HDRnNCVkeHUh?=
CRO-AP2 cell NXnteXFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGNTVy2DUEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM3ODh6IN88US=> MYHTRW5ITVJ?
CTV-1 cell MkTFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M33QXGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46OTR3IN88US=> NYTGUmY{W0GQR1XS
Calu-6 cell M{T5fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVLjOlF4UW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Py53OE[g{txO MlXvV2FPT0WU
D-247MG cell M3XGSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37zWWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NEfNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjJ6MUSg{txO NWfRcZBWW0GQR1XS
D-263MG cell NIj1TFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjhTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ4M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQDVyOTFOwG0> NFf0OIlUSU6JRWK=
D-336MG cell NHOzVlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmLFTY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh3NDFOwG0> NI\leo9USU6JRWK=
D-392MG cell M4DTPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVTtOo8{UW6qaXLpeIlwdiCxZjDoeY1idiCGLUO5Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52M{CzPUDPxE1? MonmV2FPT0WU
D-502MG cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3Kw[2lvcGmkaYTpc44hd2ZiaIXtZY4hTC13MELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTN2OUKg{txO NIXvfZVUSU6JRWK=
D-542MG cell NUTWOnh6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUC4dVJQUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{G1NkDPxE1? NUDuUo9pW0GQR1XS
DB cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHmw[|BKdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEeuNVQyPyEQvF2= M1vWdnNCVkeHUh?=
DEL cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMEG4PVgh|ryP MmPiV2FPT0WU
DMS-114 cell NFLNb5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoDpTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUG0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFkvQDR4ODFOwG0> M162PHNCVkeHUh?=
DMS-153 cell NH7te2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmjXTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvQTl{MzFOwG0> MWjTRW5ITVJ?
DOHH-2 cell NEfCUmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHXa[|BKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOjJ5NkSg{txO NGnp[pBUSU6JRWK=
DSH1 cell Mo\US5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;hc2lvcGmkaYTpc44hd2ZiaIXtZY4hTFOKMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuOFM3OjNizszN MnXNV2FPT0WU
Daudi cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYPJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wPVgxOiEQvF2= MlrCV2FPT0WU
EC-GI-10 cell NWTQS4dTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DVS2lvcGmkaYTpc44hd2ZiaIXtZY4hTUNvR1mtNVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PC5{NUi5JO69VQ>? NHLkSGFUSU6JRWK=
ECC4 cell M3vIZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1zKemlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOyMlE5QTZizszN M2XncXNCVkeHUh?=
EM-2 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{jlOGlvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFU2QTRizszN MYnTRW5ITVJ?
ES1 cell Mnr6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnlWGNKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuOVQxQDdizszN M2ji[3NCVkeHUh?=
ES3 cell MmnkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4PYb2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEKuOFczQSEQvF2= M3rWZXNCVkeHUh?=
ES4 cell NVrCW3h4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3kTY5pcWKrdHnvckBw\iCqdX3hckBGWzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|NT6xPVUh|ryP NXTxOHkzW0GQR1XS
ES6 cell NY\BTmd1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFrISJlKdmirYnn0bY9vKG:oIHj1cYFvKEWVNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlQ4OzNizszN NFPzR3ZUSU6JRWK=
ES7 cell MnnJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMkOxNlQh|ryP M1L3NnNCVkeHUh?=
ES8 cell NXzq[nlUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEG5NlQh|ryP MkezV2FPT0WU
EW-18 cell NUDIVFZpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DXcWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43PzV7IN88US=> M{jiVXNCVkeHUh?=
EW-22 cell M3T3cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWTXTXdbUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4Njd7NEeg{txO MmSzV2FPT0WU
GCIY cell NFXtb|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkiwN|g6KM7:TR?= M4\ib3NCVkeHUh?=
GDM-1 cell NU\uSoU4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGdFVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6zPVE6PiEQvF2= MXLTRW5ITVJ?
GI-1 cell M3XxO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF;Vd2lKdmirYnn0bY9vKG:oIHj1cYFvKEeLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxPTJ|IN88US=> M4fqXHNCVkeHUh?=
GI-ME-N cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA1QTVzIN88US=> MUnTRW5ITVJ?
GR-ST cell MkDIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojmTY5pcWKrdHnvckBw\iCqdX3hckBIWi2VVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlc6ODJizszN M4TxNnNCVkeHUh?=
GT3TKB cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjXTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxOzh7IN88US=> MYTTRW5ITVJ?
HAL-01 cell NIPJTGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\XdnhKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjl5MUKg{txO NH71R2FUSU6JRWK=
HCC1599 cell NWXrNG1yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\VfHF3UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxOVk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzdwNkCxNUDPxE1? MYHTRW5ITVJ?
HCC2218 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGPvPIlKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{KyNVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy5|OEO0JO69VQ>? M4[2WHNCVkeHUh?=
HD-MY-Z cell M1XvTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYrJcohq[mm2aX;uJI9nKGi3bXHuJGhFNU2\LWqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOU4zOTR4IN88US=> MVXTRW5ITVJ?
HL-60 cell MmnZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNlEyPCEQvF2= MWXTRW5ITVJ?
HOP-62 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DRemlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvQTV{NzFOwG0> NE\mcHdUSU6JRWK=
HT cell NXjlO|Q6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGhVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC52NEOyNUDPxE1? M17mcHNCVkeHUh?=
HT-144 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTF2NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPVA3QDZizszN NH7SPXdUSU6JRWK=
HUTU-80 cell NFq4S3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFuzOWFKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njd6OUi2JO69VQ>? MVjTRW5ITVJ?
IST-MEL1 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1\LbGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi57MEi2JO69VQ>? M{nNVHNCVkeHUh?=
IST-SL1 cell M37xXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXrIN4lZUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zN{C3PUDPxE1? NX[xfFFFW0GQR1XS
IST-SL2 cell M1\K[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4rBUGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjZ4MEig{txO Mo\oV2FPT0WU
K052 cell NYHnZ5dDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVSyXnp2UW6qaXLpeIlwdiCxZjDoeY1idiCNMEWyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44PTNyMTFOwG0> NFzDVlJUSU6JRWK=
K5 cell NY\YdY96T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIXY[ZdKdmirYnn0bY9vKG:oIHj1cYFvKEt3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{OuOVkyPSEQvF2= NYjLVHFEW0GQR1XS
KALS-1 cell MnLuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIr3PHhKdmirYnn0bY9vKG:oIHj1cYFvKEuDTGOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI6NjN7Nkmg{txO NEXSVndUSU6JRWK=
KARPAS-422 cell M2X6[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnuxTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwOUG0NkDPxE1? NFmyXYFUSU6JRWK=
KARPAS-45 cell M{PBXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLuTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjFzMkS3JO69VQ>? MXjTRW5ITVJ?
KE-37 cell NVHUOpNPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{\iNGlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25Mlg{PSEQvF2= MoHrV2FPT0WU
KG-1 cell M4GwSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnnjTY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuPVc2PyEQvF2= NIm4d3BUSU6JRWK=
KGN cell NIq1fHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NY\r[Gh5UW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlU3PzR{IN88US=> NFv5TllUSU6JRWK=
KM12 cell M1PvXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJGtOOTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkWyPVY1KM7:TR?= MnjDV2FPT0WU
KMOE-2 cell NF2wZpBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELHTHRKdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjR3NEmg{txO MVfTRW5ITVJ?
KNS-42 cell Ml3nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJGtPWy12MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuPFE6OTVizszN M1vyW3NCVkeHUh?=
KNS-81-FD cell M2P4XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnHjTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvOEGtSmQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py52Mk[g{txO MknYV2FPT0WU
KS-1 cell NVjSb2s{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fIcGlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFA1PiEQvF2= MnvPV2FPT0WU
KU812 cell M4\EWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3vW[mlvcGmkaYTpc44hd2ZiaIXtZY4hU1V6MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{41QDRizszN M3vQPXNCVkeHUh?=
L-540 cell NH\rWIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUjoXpFCUW6qaXLpeIlwdiCxZjDoeY1idiCOLUW0NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjd2NEWg{txO NETXZ3BUSU6JRWK=
LAMA-84 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEnaR4dKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy54N{SyJO69VQ>? NFezNmlUSU6JRWK=
LB1047-RCC cell M4HPVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHUZZZRUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuN|g5OyEQvF2= Ml7HV2FPT0WU
LB2241-RCC cell NGn1dIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjJ2MT3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC53NUO2JO69VQ>? M4jXTnNCVkeHUh?=
LB2518-MEL cell MlfCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXzzNmV1UW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVQ6Ps7:TR?= MmPTV2FPT0WU
LB831-BLC cell M1jZVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mni3TY5pcWKrdHnvckBw\iCqdX3hckBNSjh|MT3CUGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS5zN{K2JO69VQ>? NUnnS3p2W0GQR1XS
LB996-RCC cell NILBPXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1iwV2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ7OU[tVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwN{SzNUDPxE1? MlvDV2FPT0WU
LC4-1 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH3xUW9KdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvQDN2MTFOwG0> MX;TRW5ITVJ?
LOUCY cell M17JWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVLjcIxxUW6qaXLpeIlwdiCxZjDoeY1idiCOT2XDXUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTV{N{[g{txO NVrwNlZ2W0GQR1XS
LOXIMVI cell NInNN4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3LCO2lvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjJzMkKg{txO NXjHT4huW0GQR1XS
LS-123 cell MlyyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUGz[IFwUW6qaXLpeIlwdiCxZjDoeY1idiCOUz2xNlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{QS5{MkW4JO69VQ>? NHnueVJUSU6JRWK=
LU-134-A cell Mn;iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzjbWRwUW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|QuSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMUSwOlgh|ryP M2fzcnNCVkeHUh?=
LU-139 cell NWPrepRwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnrJTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk4zOThizszN MlXjV2FPT0WU
LXF-289 cell MlLSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUXJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{41OzVzzszN NVfwSohHW0GQR1XS
MC116 cell NHqxbJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlHuTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1MlA5PDFizszN MlHYV2FPT0WU
MDA-MB-134-VI cell Mkf5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVXFfItNUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTN2LW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjR6NjFOwG0> NGmwNolUSU6JRWK=
MFH-ino cell NFfkc5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fNN2lvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjR|OEOg{txO MX\TRW5ITVJ?
MHH-NB-11 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1;2Z2lvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLV7CMVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNk[5JO69VQ>? NYDEfWxZW0GQR1XS
ML-2 cell NYG4fGttT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{\Id2lvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOFA{ODRizszN Ml75V2FPT0WU
MOLT-13 cell NFTHXldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{CwPWlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPDN4NUOg{txO NGfJflZUSU6JRWK=
MOLT-16 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkTTTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yOTF4MzFOwG0> MUXTRW5ITVJ?
MOLT-4 cell NXrwRYdYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHLPWtsUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC52MUK0JO69VQ>? M{L5R3NCVkeHUh?=
MPP-89 cell NVPVNJM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlU6OjJizszN NYDZU2Z7W0GQR1XS
MRK-nu-1 cell M{PzfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PnNWlvcGmkaYTpc44hd2ZiaIXtZY4hVVKNLX71MVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjV5NUeyJO69VQ>? NXPyblJFW0GQR1XS
MSTO-211H cell NXq4WolYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfuSo5PUW6qaXLpeIlwdiCxZjDoeY1idiCPU2TPMVIyOUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64Olkh|ryP MXrTRW5ITVJ?
MV-4-11 cell Mn3CS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFXWN2dKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF|OUG1JO69VQ>? MULTRW5ITVJ?
NALM-6 cell M4jLOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7rd4hKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTZzMEmg{txO NGXVZ2xUSU6JRWK=
NB1 cell M1v1Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKGi3bXHuJG5DOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOESzOlkh|ryP MlvzV2FPT0WU
NB10 cell NF3Cb2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1n5fmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVM6OTVizszN MVTTRW5ITVJ?
NB12 cell M4PvRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nSdmlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG2MlU3PTZizszN MnzZV2FPT0WU
NB13 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkOxNlc5KM7:TR?= MXPTRW5ITVJ?
NB17 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkW4NFUyKM7:TR?= M{nWXXNCVkeHUh?=
NB6 cell M2G5e2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUmxNVQh|ryP NIf1R4VUSU6JRWK=
NCCIT cell M3SzRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4DQTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOFSWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20NU45PDV|IN88US=> MnjkV2FPT0WU
NCI-H1155 cell NV3HWm53T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUG1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjN2MEig{txO Mn7HV2FPT0WU
NCI-H1304 cell M3K3OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUOwOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjh7OEKg{txO M17OPXNCVkeHUh?=
NCI-H1355 cell M2rMfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzxdJdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVM2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwOUSxNUDPxE1? NY[5VXNsW0GQR1XS
NCI-H1395 cell MnG1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5OUWg{txO NGL3WJRUSU6JRWK=
NCI-H1417 cell NVrBdIVWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrBbWlKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQyPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNke1NlIh|ryP NVXBVVNPW0GQR1XS
NCI-H1436 cell NX\teIkxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYrGTZRuUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE1OzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lki0NVAyKM7:TR?= NFn6ZYpUSU6JRWK=
NTERA-S-cl-D1 cell NWDEZmNiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHryNm9KdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk45QTN3IN88US=> NX3vToluW0GQR1XS
JiyoyeP-2003 cell NVX6WlFZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XDRWlvcGmkaYTpc44hd2ZiaIXtZY4hUmm7b4nlVE0zODB|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{[uOlI5PCEQvF2= MUfTRW5ITVJ?

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In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: female Wistar rats
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Water Insoluble
Ethanol '6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 2095432-71-4
Storage powder
in solvent
Synonyms GSK269962B, GSK269962, GSK 269962
Smiles CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID