GSK269962A HCl

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

For research use only.

GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

GSK269962A HCl Chemical Structure

CAS No. 2095432-71-4

Selleck's GSK269962A HCl has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NFrZ[WJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHpTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG1PFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56NEe3JO69VQ>? M2XuOnNCVkeHUh?=
NCI-H1694 MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjvboNpUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3QTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{ND64O|Q6KM7:TR?= MXnTRW5ITVJ?
NCI-H1963 NXiwV2JlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUm2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd6M{mg{txO NIjyRZhUSU6JRWK=
NCI-H2081 Mo\lS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPERlBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN2Lk[wOFQh|ryP NXfScIg{W0GQR1XS
NCI-H209 NEHyZYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4nSVWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi54MkeyJO69VQ>? MneyV2FPT0WU
NCI-H2107 NELGXZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGrvRZRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlExPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ3Lk[1OlEh|ryP Mn3jV2FPT0WU
NCI-H2126 M4HjfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2Gx[GlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi53MESyOkDPxE1? MofOV2FPT0WU
NCI-H2171 MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG3NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTV7M{eg{txO MULTRW5ITVJ?
NCI-H2227 MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkKyO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvQDh4MU[g{txO M{TsbnNCVkeHUh?=
NCI-H524 MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF3iUWxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwOEe2N{DPxE1? NXvWcVVnW0GQR1XS
NCI-H526 M{X3fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoC3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjV2M{Gg{txO NXH0cpFZW0GQR1XS
NCI-H720 MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41PTF4MTFOwG0> NX;SVVQ4W0GQR1XS
NMC-G1 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzhe4hyUW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5yNUe4JO69VQ>? M{LGbHNCVkeHUh?=
NOS-1 cell MkXaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmrtTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuPFIzQTRizszN MULTRW5ITVJ?
OCI-AML2 cell M3\y[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTR7NjFOwG0> NYOybohVW0GQR1XS
OCUB-M cell NGLWeZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUfPR|dsUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy5{MEGg{txO NH71NpJUSU6JRWK=
ONS-76 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2KxUmlvcGmkaYTpc44hd2ZiaIXtZY4hV06VLUe2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQTF7MTFOwG0> NUTFPFdLW0GQR1XS
OS-RC-2 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUfkdI8yUW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDZwMUm1JO69VQ>? MnjqV2FPT0WU
OVCAR-4 cell M2TOSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVjqU25uUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55MUiwPEDPxE1? NFm1OY1USU6JRWK=
P30-OHK cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVvJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlYzQDd5IN88US=> MWnTRW5ITVJ?
P30-OHK cell NHH2ZYVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNFQ6PTRizszN NH3Se4JUSU6JRWK=
PSN1 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGjlNIRKdmirYnn0bY9vKG:oIHj1cYFvKFCVTkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlIzOTJ4IN88US=> NYTVc4ZXW0GQR1XS
QIMR-WIL cell NHu4XmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{DwT2lvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR7MEC0JO69VQ>? MkHJV2FPT0WU
RCC10RGB cell NGXBSnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIL5dZFKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOUCzOkDPxE1? M1LRV3NCVkeHUh?=
RKO cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkW2OlIh|ryP NXriNVhZW0GQR1XS
RL95-2 cell M1S5Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\r[mZKdmirYnn0bY9vKG:oIHj1cYFvKFKOOUWtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ5IN88US=> M3HXbHNCVkeHUh?=
RPMI-6666 cell MoP0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjrfYdKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkWyN|Yh|ryP NFnKZYxUSU6JRWK=
RPMI-8402 cell MnG4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXOTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjV6NU[g{txO NVvTTmY1W0GQR1XS
RXF393 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn\kTY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlM6OyEQvF2= MWLTRW5ITVJ?
Ramos-2G6-4C10 cell MlTtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmnNTY5pcWKrdHnvckBw\iCqdX3hckBT[W2xcz2yS|YuPENzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|U4KM7:TR?= MnjQV2FPT0WU
SCLC-21H cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIH6b3hKdmirYnn0bY9vKG:oIHj1cYFvKFOFTFOtNlFJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54MUG0PUDPxE1? NHqyO41USU6JRWK=
SF126 cell NXX2SY97T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF:0bpRKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvQDN{Md88US=> NYjUUZNyW0GQR1XS
SF268 cell NX;tNohxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yN|E5OyEQvF2= NHi1bGtUSU6JRWK=
SF539 cell NE\LWFBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnHXTY5pcWKrdHnvckBw\iCqdX3hckBUTjV|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlg3PjFizszN NVX0b|JVW0GQR1XS
SH-4 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mkf2TY5pcWKrdHnvckBw\iCqdX3hckBUUC12IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT63OVUxQCEQvF2= NV;HTWN2W0GQR1XS
SIG-M5 cell NIPk[nNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEXXSJpKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd{NUmg{txO NIjOOItUSU6JRWK=
SJSA-1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNLW0FvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFQ2OjZizszN NUXURW1QW0GQR1XS
SK-LMS-1 cell M1P5emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jKbGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi53OU[1JO69VQ>? MofpV2FPT0WU
SK-MM-2 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{n6Z2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTV2tNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjN2MEWg{txO NWPIUmxMW0GQR1XS
SK-N-DZ cell M{Hlbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU5vRGqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlQ5OzF2IN88US=> M4\veXNCVkeHUh?=
SK-NEP-1 cell MkTuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVSzVlhuUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF5LkW0OVYh|ryP MWTTRW5ITVJ?
SK-PN-DW cell M{fPVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFu0WFdKdmirYnn0bY9vKG:oIHj1cYFvKFONLWDOMWRYKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjRwOUezOkDPxE1? M3ywSXNCVkeHUh?=
SNB75 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGfsdohKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzd|NzFOwG0> MWLTRW5ITVJ?
SR cell NEnEVFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NInjbpRKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFAyOzdizszN MUPTRW5ITVJ?
SU-DHL-1 cell NU\MNpdVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkXXTY5pcWKrdHnvckBw\iCqdX3hckBUXS2GSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd|M{[g{txO MlPhV2FPT0WU
SW684 cell M1W3Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzmboJKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvODFzIN88US=> M1vyNnNCVkeHUh?=
SW872 cell NFzkWGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64PFY2PiEQvF2= NHXudJJUSU6JRWK=
SW962 cell Ml\6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWTk[pA{UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd3MkGg{txO MWTTRW5ITVJ?
697 cell NXXnR|cxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1vQXmlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPVkyKM7:TR?= MV\TRW5ITVJ?
8-MG-BA cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDLTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvODd7MzFOwG0> NXfp[2xYW0GQR1XS
A101D cell M{\TbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWnJcohq[mm2aX;uJI9nKGi3bXHuJGEyODGGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64O|A{PCEQvF2= MYXTRW5ITVJ?
ACN cell Mnm0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFuxR5lKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlQ{QDdizszN NULxO2xuW0GQR1XS
AM-38 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjlTY5pcWKrdHnvckBw\iCqdX3hckBCVS1|ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNlY{OjdizszN M3W1dXNCVkeHUh?=
ATN-1 cell NVjlZ5d5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkSuO|U2PSEQvF2= MUnTRW5ITVJ?
BB30-HNC cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjV|MjFOwG0> NWHqRoI3W0GQR1XS
BB49-HNC cell NIniS|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGJDPDlvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODd6OTFOwG0> M{CwNHNCVkeHUh?=
human BC-1 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lkm3NVA4KM7:TR?= M{K0bHNCVkeHUh?=
BE-13 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOFA5Oc7:TR?= MWfTRW5ITVJ?
BL-70 cell M1;YbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{TJOGlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxPzB|IN88US=> M1rSR3NCVkeHUh?=
BV-173 cell NX7u[5A5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFXNelVKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh6NUmg{txO M4TOd3NCVkeHUh?=
Becker cell MnPOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlLsTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{46PTR3IN88US=> NX;GOYh7W0GQR1XS
CAL-148 cell NEjkfnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWCycHhOUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytNVQ5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzVwNkW1O{DPxE1? MmnhV2FPT0WU
TE-10 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoD5TY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKyMlg1OjNizszN MX3TRW5ITVJ?
TE-12 cell NV33OFRlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M13aNWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk41OTF2IN88US=> MXPTRW5ITVJ?
TE-8 cell NULHdm9RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGnLPXFKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43ODh7IN88US=> NGf2WldUSU6JRWK=
TE-9 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NE\qR|NKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43OzhzIN88US=> MlPBV2FPT0WU
TGW cell Mnz2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlz4TY5pcWKrdHnvckBw\iCqdX3hckBVT1diY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mz6zOVc4KM7:TR?= MnHvV2FPT0WU
UACC-257 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjBTY5pcWKrdHnvckBw\iCqdX3hckBWSUOFLUK1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPzB4MkWg{txO MXfTRW5ITVJ?
WSU-NHL cell NH3mNplIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmPrTY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlcvOTlyNzFOwG0> NYnZbG1qW0GQR1XS
no-10 cell MoCyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTWWnJWUW6qaXLpeIlwdiCxZjDoeY1idiCwbz2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjZ6NE[g{txO NXu4RYN{W0GQR1XS
no-11 cell NIG1WGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEDJTY5KdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFcvODJ4MzFOwG0> NX\wTnM2W0GQR1XS
CAS-1 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4fFbmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1PyEQvF2= MmjXV2FPT0WU
CCRF-CEM cell NUDtNohwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkHPTY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjV|OUKg{txO MlH4V2FPT0WU
CMK cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEGzNlMh|ryP Ml;pV2FPT0WU
COLO-829 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2nG[mlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24Nlkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ2MkK2JO69VQ>? Mm[5V2FPT0WU
COR-L279 cell NIDQOZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYXmXIZ6UW6qaXLpeIlwdiCxZjDoeY1idiCFT2KtUFI4QSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMEezPEDPxE1? NEP2VlBUSU6JRWK=
CP66-MEL cell MnLUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGNRPjZvTVXMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvPTR7NzFOwG0> MWjTRW5ITVJ?
CRO-AP2 cell NVPtR2YzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3zCbWlvcGmkaYTpc44hd2ZiaIXtZY4hS1KRLVHQNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzZyOEig{txO M1LiWXNCVkeHUh?=
CTV-1 cell MkHmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUXJcohq[mm2aX;uJI9nKGi3bXHuJGNVXi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuPVE1PSEQvF2= NYXsWZJ2W0GQR1XS
Calu-6 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4KzcGlvcGmkaYTpc44hd2ZiaIXtZY4hS2GudT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFcvPTh4IN88US=> MUDTRW5ITVJ?
D-247MG cell NIO0VYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnL3TY5pcWKrdHnvckBw\iCqdX3hckBFNTJ2N13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43OjhzNDFOwG0> NGDMW41USU6JRWK=
D-263MG cell M1rae2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5PTB7IN88US=> MnXYV2FPT0WU
D-336MG cell NG\RXlNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33RS2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjJ6NUSg{txO NYPwV2lNW0GQR1XS
D-392MG cell M3\RWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF;QcHlKdmirYnn0bY9vKG:oIHj1cYFvKERvM{myUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR|MEO5JO69VQ>? NF20TFhUSU6JRWK=
D-502MG cell NI\VZnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWLxWIRKUW6qaXLpeIlwdiCxZjDoeY1idiCGLUWwNm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC53M{S5NkDPxE1? Mmj5V2FPT0WU
D-542MG cell MnvMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkfuTY5pcWKrdHnvckBw\iCqdX3hckBFNTV2Ml3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvOzF3MjFOwG0> M1GwTXNCVkeHUh?=
DB cell M4X3bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkPVTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR5LkG0NVch|ryP NEjtZ4lUSU6JRWK=
DEL cell NE\DcVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVXwSno6UW6qaXLpeIlwdiCxZjDoeY1idiCGRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlAyQDl6IN88US=> NWLlS4lDW0GQR1XS
DMS-114 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUjxTFl2UW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVE1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDlwOES2PEDPxE1? MWTTRW5ITVJ?
DMS-153 cell NYrONpduT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{m2RWlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUG1N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjl7MkOg{txO NUTIfIhxW0GQR1XS
DOHH-2 cell NYDjXY55T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PjRizszN M1nFVHNCVkeHUh?=
DSH1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnfiTY5pcWKrdHnvckBw\iCqdX3hckBFW0hzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD60N|YzOyEQvF2= NIX5epNUSU6JRWK=
Daudi cell M3LhOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGO2WmVKdmirYnn0bY9vKG:oIHj1cYFvKESjdXTpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xQThyMjFOwG0> NWjNelRyW0GQR1XS
EC-GI-10 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFnOcJJKdmirYnn0bY9vKG:oIHj1cYFvKEWFLVfJMVExKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDRwMkW4PUDPxE1? NWfvfoNpW0GQR1XS
ECC4 cell M{n3O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEn1bmtKdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk4yQDl4IN88US=> NY\NU2htW0GQR1XS
EM-2 cell M1S3VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXQd5VVUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41PTV7NDFOwG0> MUnTRW5ITVJ?
ES1 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmK2TY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkW0NFg4KM7:TR?= MnrvV2FPT0WU
ES3 cell NHnLVWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIm3RVBKdmirYnn0bY9vKG:oIHj1cYFvKEWVMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSyMlQ4OjlizszN MmjsV2FPT0WU
ES4 cell NH3Ge|BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfPTY5pcWKrdHnvckBw\iCqdX3hckBGWzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|NT6xPVUh|ryP MkjuV2FPT0WU
ES6 cell NFHaWHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\NUVFMUW6qaXLpeIlwdiCxZjDoeY1idiCHU{[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI1PzN|IN88US=> NWDQ[JhqW0GQR1XS
ES7 cell M1XSZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMkOxNlQh|ryP NEPGZZhUSU6JRWK=
ES8 cell NHLKPIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUe3VGtpUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlgyQTJ2IN88US=> M3K1enNCVkeHUh?=
EW-18 cell Ml3kS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDMPFJKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjd3OTFOwG0> MkTnV2FPT0WU
EW-22 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjGTY5pcWKrdHnvckBw\iCqdX3hckBGXy1{MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3Mlc6PDdizszN MUfTRW5ITVJ?
GCIY cell NH7TTVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1;rfGlvcGmkaYTpc44hd2ZiaIXtZY4hT0OLWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuPFA{QDlizszN NGnQTYJUSU6JRWK=
GDM-1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4LFVWlvcGmkaYTpc44hd2ZiaIXtZY4hT0SPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlM6OTl4IN88US=> M1fhNXNCVkeHUh?=
GI-1 cell NYjV[3JbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGdKNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwOVI{KM7:TR?= NEHsNpNUSU6JRWK=
GI-ME-N cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA1QTVzIN88US=> MnLoV2FPT0WU
GR-ST cell Mn\hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnFPGRKdmirYnn0bY9vKG:oIHj1cYFvKEeULWPUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPzlyMjFOwG0> MWLTRW5ITVJ?
GT3TKB cell NYWwWHNYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TDN2lvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODN6OTFOwG0> NEPuVWFUSU6JRWK=
HAL-01 cell NV\wdZBkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjrTGhnUW6qaXLpeIlwdiCxZjDoeY1idiCKQVytNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjZ7N{GyJO69VQ>? MVrTRW5ITVJ?
HCC1599 cell M4nSWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkTHTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzNUm5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|cvPjBzMTFOwG0> MnvrV2FPT0WU
HCC2218 cell NEfDT3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJGhESzJ{MUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{QDN2IN88US=> NXftOnhmW0GQR1XS
HD-MY-Z cell NFTVWVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHntR49KdmirYnn0bY9vKG:oIHj1cYFvKEiGLV3ZMXoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPS5{MUS2JO69VQ>? NXPCVpRzW0GQR1XS
HL-60 cell NXXQOIdyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1fzfGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4zOTF2IN88US=> MmrvV2FPT0WU
HOP-62 cell NYHoSZc6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7jWVgzUW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtOlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy57NUK3JO69VQ>? MULTRW5ITVJ?
HT cell NFLyblVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2f6XGlvcGmkaYTpc44hd2ZiaIXtZY4hUFRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0N|IyKM7:TR?= M4j1XXNCVkeHUh?=
HT-144 cell M4W4SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGq1NIRKdmirYnn0bY9vKG:oIHj1cYFvKEiWLUG0OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQTB4OE[g{txO NH3rfIlUSU6JRWK=
HUTU-80 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TOeWlvcGmkaYTpc44hd2ZiaIXtZY4hUFWWVT24NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPzh7OE[g{txO NUi2ZopUW0GQR1XS
IST-MEL1 cell NFi0W3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2PRVyxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvQTB6NjFOwG0> MlPqV2FPT0WU
IST-SL1 cell MkTuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\zNm1KdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjF5MEe5JO69VQ>? M1TMXXNCVkeHUh?=
IST-SL2 cell M2HnXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlI3PjB6IN88US=> NWS3SJVTW0GQR1XS
K052 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1z0VmlvcGmkaYTpc44hd2ZiaIXtZY4hUzB3MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|U{ODFizszN NHzqeVlUSU6JRWK=
K5 cell NUXWUpc3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPufFhKdmirYnn0bY9vKG:oIHj1cYFvKEt3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{OuOVkyPSEQvF2= NFq5SnZUSU6JRWK=
KALS-1 cell NH:2U4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm[4TY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{QTZ7IN88US=> M{nvPHNCVkeHUh?=
KARPAS-422 cell MoLBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVXNfZJbUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDJ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEKuPVE1OiEQvF2= NXq0[W46W0GQR1XS
KARPAS-45 cell NIPOOWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfMVXlKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwMUGyOFch|ryP MlTuV2FPT0WU
KE-37 cell Mn;BS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEXQRnZKdmirYnn0bY9vKG:oIHj1cYFvKEuHLUO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU45OzVizszN NEPwfpBUSU6JRWK=
KG-1 cell NFnFSIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnTwTY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuPVc2PyEQvF2= NGjYeJRUSU6JRWK=
KGN cell NHvOWZJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4f0OGlvcGmkaYTpc44hd2ZiaIXtZY4hU0eQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61Olc1OiEQvF2= NVXuSGk2W0GQR1XS
KM12 cell M2fJSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3kT3FWUW6qaXLpeIlwdiCxZjDoeY1idiCNTUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42Ojl4NDFOwG0> NYfpcJI2W0GQR1XS
KMOE-2 cell NGfiV2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHKxbW9KdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjR3NEmg{txO NGXtTpBUSU6JRWK=
KNS-42 cell NWDLWndsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mmn1TY5pcWKrdHnvckBw\iCqdX3hckBMVlNvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlgyQTF3IN88US=> NETwWoZUSU6JRWK=
KNS-81-FD cell M3LaUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHuTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvOEGtSmQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py52Mk[g{txO MXfTRW5ITVJ?
KS-1 cell NITZeFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;Yb3NtUW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODR4IN88US=> Ml7YV2FPT0WU
KU812 cell NW\FOY5PT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NG\uN3pKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPDh2IN88US=> NX6xcGE4W0GQR1XS
L-540 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX;nZoM5UW6qaXLpeIlwdiCxZjDoeY1idiCOLUW0NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIxNjd2NEWg{txO M4fpfHNCVkeHUh?=
LAMA-84 cell NYDYXHVFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGxCVUFvOESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43PzR{IN88US=> M4i4NHNCVkeHUh?=
LB1047-RCC cell NE\kdZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQC5|OEizJO69VQ>? M{npW3NCVkeHUh?=
LB2241-RCC cell Ml;nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;SToRGUW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVU{PiEQvF2= NYjnO5dLW0GQR1XS
LB2518-MEL cell NIPuSHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFi1N29KdmirYnn0bY9vKG:oIHj1cYFvKEyEMkWxPE1OTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkexOFk3|ryP MoDjV2FPT0WU
LB831-BLC cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3LobmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ6M{GtRmxEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUeyOkDPxE1? NWTqSIpnW0GQR1XS
LB996-RCC cell NHOwWWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJGxDQTl4LWLDR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd2M{Gg{txO Mn\mV2FPT0WU
LC4-1 cell NGXBe2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1nQSmlvcGmkaYTpc44hd2ZiaIXtZY4hVEN2LUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk45OzRzIN88US=> M2XkSnNCVkeHUh?=
LOUCY cell M4WzSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWqy[Jp7UW6qaXLpeIlwdiCxZjDoeY1idiCOT2XDXUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTV{N{[g{txO M2e5e3NCVkeHUh?=
LOXIMVI cell NUnZV5YxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFXTTWJKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{OC5{MUKyJO69VQ>? MVXTRW5ITVJ?
LS-123 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3f0XmlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvMUKzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjJ3ODFOwG0> MnjKV2FPT0WU
LU-134-A cell M{nrR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJGxWNTF|ND3BJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4yPDB4ODFOwG0> NV3vcJB{W0GQR1XS
LU-139 cell NIHwdVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWrofIlCUW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi5{MUig{txO M4rhSXNCVkeHUh?=
LXF-289 cell NYPuSlRKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xO{41OzVzzszN MmnsV2FPT0WU
MC116 cell MlnwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HBb2lvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU4xQDRzIN88US=> MkL6V2FPT0WU
MDA-MB-134-VI cell MmXnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXRXW1KdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yOzRvVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4zPDh4IN88US=> Mn;hV2FPT0WU
MFH-ino cell M1jsXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\n[mlvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjR|OEOg{txO M1q5THNCVkeHUh?=
MHH-NB-11 cell Mk\VS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1LCO2lvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLV7CMVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yNk[5JO69VQ>? M1X2dHNCVkeHUh?=
ML-2 cell NILxZ5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIHWR41KdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxOzB2IN88US=> NYX6fIZHW0GQR1XS
MOLT-13 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjrZZNKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR|NkWzJO69VQ>? NGO5O29USU6JRWK=
MOLT-16 cell MlHIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFPVTYxKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjFzMU[zJO69VQ>? NVHU[5d7W0GQR1XS
MOLT-4 cell NHnkcmlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLKOG1KdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjRzMkSg{txO NV;Sc44{W0GQR1XS
MPP-89 cell MonHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;sSGlvcGmkaYTpc44hd2ZiaIXtZY4hVVCSLUi5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPTl{MjFOwG0> MXvTRW5ITVJ?
MRK-nu-1 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkTMTY5pcWKrdHnvckBw\iCqdX3hckBOWktvboWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTd3N{Kg{txO NF\TUYNUSU6JRWK=
MSTO-211H cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7kVIxKdmirYnn0bY9vKG:oIHj1cYFvKE2VVF:tNlEyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF{Lki2PUDPxE1? MX3TRW5ITVJ?
MV-4-11 cell NVPZ[Zk4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\lVJhKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF|OUG1JO69VQ>? M2L0UHNCVkeHUh?=
NALM-6 cell NXP5UHdyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4jkbWlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PjFyOTFOwG0> NEj0SYxUSU6JRWK=
NB1 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1vzUGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64OFM3QSEQvF2= MULTRW5ITVJ?
NB10 cell MmLBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVe1NWxDUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOzlzNTFOwG0> MWDTRW5ITVJ?
NB12 cell NUXlSIVtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlrXTY5pcWKrdHnvckBw\iCqdX3hckBPSjF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MU[uOVY2PiEQvF2= M4LkR3NCVkeHUh?=
NB13 cell NHf4UWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYnJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkOxNlc5KM7:TR?= MVHTRW5ITVJ?
NB17 cell MkfpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEDXNldKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlU5ODVzIN88US=> NHTRc2FUSU6JRWK=
NB6 cell NILFXG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1S1emlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61PVEyPCEQvF2= M3rzT3NCVkeHUh?=
NCCIT cell NV;ZZVZpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnrtTY5pcWKrdHnvckBw\iCqdX3hckBPS0OLVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSxMlg1PTNizszN M13HVnNCVkeHUh?=
NCI-H1155 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37F[GlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwM{SwPEDPxE1? NFjXZY9USU6JRWK=
NCI-H1304 cell NHvENolIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUOwOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjh7OEKg{txO NVjnZ4YxW0GQR1XS
NCI-H1355 cell M3LWcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQTRzMTFOwG0> MVrTRW5ITVJ?
NCI-H1395 cell M3HrRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUO5OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5OUWg{txO NIHhTIJUSU6JRWK=
NCI-H1417 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPJTI5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQyPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNke1NlIh|ryP NYDhSGI5W0GQR1XS
NCI-H1436 cell NFLTbphIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{HSV2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOFM3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56NEGwNUDPxE1? NXHKNWFkW0GQR1XS
NTERA-S-cl-D1 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64PVM2KM7:TR?= M2\kOnNCVkeHUh?=
JiyoyeP-2003 cell NID1c3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJGpqgW:7ZWCtNlAxOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN4Lk[yPFQh|ryP MmjtV2FPT0WU
In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
Animal Research:[2]
  • Animal Models: female Wistar rats
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(164.72 mM)
Water Insoluble
Ethanol '6 mg/mL

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 2095432-71-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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