GSK269962A HCl

For research use only.

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

4 publications

GSK269962A HCl Chemical Structure

CAS No. 2095432-71-4

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NYjISXo3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFHXc2dKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVU5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6Lki0O|ch|ryP MoDTV2FPT0WU
NCI-H1694 NVzPbmpwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYS2dZp5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3QTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{ND64O|Q6KM7:TR?= MnrXV2FPT0WU
NCI-H1963 NWDtcm5wT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkjaTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG5OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ5OEO5JO69VQ>? NVjme3FNW0GQR1XS
NCI-H2081 NIi1cpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4PpN2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFgyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwNkC0OEDPxE1? NWfaR|RQW0GQR1XS
NCI-H209 MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY\tWHJmUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[yO|Ih|ryP NUOwO3VmW0GQR1XS
NCI-H2107 M{D3R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnTVoFQUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyODdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{NT62OVYyKM7:TR?= NUHCdFYyW0GQR1XS
NCI-H2126 NHvFe25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPTB2Mk[g{txO MnPnV2FPT0WU
NCI-H2171 M4[xcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlO5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxO|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl3OUO3JO69VQ>? NUHW[4hUW0GQR1XS
NCI-H2227 MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjRTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKyNlch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njh6NkG2JO69VQ>? MnPsV2FPT0WU
NCI-H524 MlvLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTCTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh5NkOg{txO NGrqPXJUSU6JRWK=
NCI-H526 MnjKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPTR|MTFOwG0> NWH3dpB[W0GQR1XS
NCI-H720 M3LrfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfQTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEeyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDVzNkGg{txO NXzIOXpDW0GQR1XS
NMC-G1 MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2nZN2lvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvODV5ODFOwG0> NVzPR483W0GQR1XS
NOS-1 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGW2bmhKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45OjJ7NDFOwG0> MlPCV2FPT0WU
OCI-AML2 cell MnvvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M162eGlvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC57NEm2JO69VQ>? MUHTRW5ITVJ?
OCUB-M cell Ml35S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLiNJRZUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy5{MEGg{txO MoG1V2FPT0WU
ONS-76 cell M3LLSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJG9PWy15NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlkyQTFizszN MVnTRW5ITVJ?
OS-RC-2 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHPvcmxKdmirYnn0bY9vKG:oIHj1cYFvKE:VLWLDMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Pi5zOUWg{txO NGTnemRUSU6JRWK=
OVCAR-4 cell NV\WTJF5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn7qTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE44OThyODFOwG0> NU\tfY9uW0GQR1XS
P30-OHK cell MkXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlYzQDd5IN88US=> MojNV2FPT0WU
P30-OHK cell NX\XV2Q1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWf5U5R[UW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB2OUW0JO69VQ>? M1PRcHNCVkeHUh?=
PSN1 cell M3rKbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGXhRldKdmirYnn0bY9vKG:oIHj1cYFvKFCVTkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlIzOTJ4IN88US=> MWHTRW5ITVJ?
QIMR-WIL cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIDlRlNKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52OUCwOEDPxE1? MkTEV2FPT0WU
RCC10RGB cell MnrZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2[wO2lvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC57MEO2JO69VQ>? M1fXXnNCVkeHUh?=
RKO cell Ml;JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mo\CTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OlYzKM7:TR?= MYfTRW5ITVJ?
RL95-2 cell Ml;SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYHQeo54UW6qaXLpeIlwdiCxZjDoeY1idiCUTEm1MVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC54NzFOwG0> NYTIeFRmW0GQR1XS
RPMI-6666 cell NIDtSGpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFTYPIJKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtOlY3PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkWyN|Yh|ryP M{TtbHNCVkeHUh?=
RPMI-8402 cell M{naSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYLwfZdIUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVg1ODJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW4OVYh|ryP NX7lW5BmW0GQR1XS
RXF393 cell MlHPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUHJcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|k{KM7:TR?= NWK5bVhKW0GQR1XS
Ramos-2G6-4C10 cell NWLTUoVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYLJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOVch|ryP M1\VbXNCVkeHUh?=
SCLC-21H cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfzd3hCUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1zDMVIyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkGxOFkh|ryP Mn\SV2FPT0WU
SF126 cell NF:4[FNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfjTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlg{OjIQvF2= MlHTV2FPT0WU
SF268 cell M{HUUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3sc4Z5UW6qaXLpeIlwdiCxZjDoeY1idiCVRkK2PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvOjNzOEOg{txO MkPnV2FPT0WU
SF539 cell NGDlWVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPNR4tqUW6qaXLpeIlwdiCxZjDoeY1idiCVRkWzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjh4NkGg{txO NWTBTIQxW0GQR1XS
SH-4 cell NW\2TYNHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHzeJF4UW6qaXLpeIlwdiCxZjDoeY1idiCVSD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44PTVyODFOwG0> NF:5VYtUSU6JRWK=
SIG-M5 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MULJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlczPTlizszN NUHSfJVvW0GQR1XS
SJSA-1 cell MmK1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHf5[WZKdmirYnn0bY9vKG:oIHj1cYFvKFOMU1GtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODR3Mk[g{txO NUjrNWdNW0GQR1XS
SK-LMS-1 cell NHzMPZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\veFZKdmirYnn0bY9vKG:oIHj1cYFvKFONLVzNV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzJwNUm2OUDPxE1? NGTXV2NUSU6JRWK=
SK-MM-2 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWH1bVhnUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NUU0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwM{SwOUDPxE1? MmDvV2FPT0WU
SK-N-DZ cell NFr1WHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXXVS25YUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OMWRbKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QS52OEOxOEDPxE1? NGXJWY9USU6JRWK=
SK-NEP-1 cell M3TDWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XwfGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPy53NEW2JO69VQ>? M{XNPHNCVkeHUh?=
SK-PN-DW cell NISx[mhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmH3TY5pcWKrdHnvckBw\iCqdX3hckBUUy2STj3EW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1Njl5M{[g{txO M4fEV3NCVkeHUh?=
SNB75 cell M4[2bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXmcZdXUW6qaXLpeIlwdiCxZjDoeY1idiCVTlK3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvODd5M{eg{txO MmnHV2FPT0WU
SR cell NXjFW4RrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\ydFVUUW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNFAxOTN5IN88US=> M{XudHNCVkeHUh?=
SU-DHL-1 cell NInvVJVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrFb3JMUW6qaXLpeIlwdiCxZjDoeY1idiCVVT3ETGwuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF{LkezN|Yh|ryP MojpV2FPT0WU
SW684 cell NHzpRYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWLJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{muNFEyKM7:TR?= NUDjdVQ6W0GQR1XS
SW872 cell MoC5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFLHTlZKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45QDZ3NjFOwG0> M3jFZ3NCVkeHUh?=
SW962 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEW2RXJKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzV{MTFOwG0> MVHTRW5ITVJ?
697 cell NX;DdIltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1HlTWlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPVkyKM7:TR?= M3v0V3NCVkeHUh?=
8-MG-BA cell NIK0XWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH25botKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy5yN{mzJO69VQ>? NH:1OYFUSU6JRWK=
A101D cell NVS3UXN7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGEyODGGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64O|A{PCEQvF2= NFT3OmtUSU6JRWK=
ACN cell NI\OellIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4TLTGlvcGmkaYTpc44hd2ZiaIXtZY4hSUOQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuOFM5PyEQvF2= MXTTRW5ITVJ?
AM-38 cell M3TWfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLWclRKdmirYnn0bY9vKG:oIHj1cYFvKEGPLUO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4zPjN{NzFOwG0> MUXTRW5ITVJ?
ATN-1 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkSuO|U2PSEQvF2= Mn;xV2FPT0WU
BB30-HNC cell NVuw[npET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlnZTY5pcWKrdHnvckBw\iCqdX3hckBDSjNyLVjOR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjJ3M{Kg{txO NX7FXFZkW0GQR1XS
BB49-HNC cell M1jNb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVz1VnY{UW6qaXLpeIlwdiCxZjDoeY1idiCEQkS5MWhPSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMEC3PFkh|ryP NX21enRKW0GQR1XS
human BC-1 cell NHfEXG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3u3NmlvcGmkaYTpc44hd2ZiaIXtZY4hSkNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPVcyODdizszN M4Djb3NCVkeHUh?=
BE-13 cell NWT6VoxoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\6TY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVQxQDIQvF2= NGDnco5USU6JRWK=
BL-70 cell M1nCOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV\PfZgzUW6qaXLpeIlwdiCxZjDoeY1idiCETD23NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPDB5MEOg{txO M33zS3NCVkeHUh?=
BV-173 cell M1fwZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NES1fo1KdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh6NUmg{txO NEDKb4lUSU6JRWK=
Becker cell NFn5c4JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\kZndKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl3NEWg{txO NFjBWYxUSU6JRWK=
CAL-148 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGNCVC1zNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOU43PTV5IN88US=> NYj6VJNrW0GQR1XS
TE-10 cell NGG5WHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIS3eHNKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvQDR{MzFOwG0> Ml:1V2FPT0WU
TE-12 cell M4jMfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXL5e3BVUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjRzMUSg{txO NVjPVHU{W0GQR1XS
TE-8 cell MmjJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3zPOGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlYxQDlizszN NUTldWZyW0GQR1XS
TE-9 cell MnTVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HNdWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvOTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO2MlY{QDFizszN MYrTRW5ITVJ?
TGW cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVTJcohq[mm2aX;uJI9nKGi3bXHuJHRIXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|LkO1O|ch|ryP NXnqUHE3W0GQR1XS
UACC-257 cell NHvXXnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFLaW2RKdmirYnn0bY9vKG:oIHj1cYFvKFWDQ1OtNlU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC55ME[yOUDPxE1? M{HINHNCVkeHUh?=
WSU-NHL cell M3fNZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHdUXS2QSFygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yO{4yQTB5IN88US=> Ml3VV2FPT0WU
no-10 cell M33QPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFrjT|JKdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Pjh2NjFOwG0> MXXTRW5ITVJ?
no-11 cell M2iwWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjtTGRKdmirYnn0bY9vKG:oIHj1cYFvKG6xLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFcvODJ4MzFOwG0> MXjTRW5ITVJ?
CAS-1 cell MljLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGLFR2tKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45PDdizszN M{SzTHNCVkeHUh?=
CCRF-CEM cell NXXRdpdUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV[5Xok3UW6qaXLpeIlwdiCxZjDoeY1idiCFQ2LGMWNGVSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRThwNkWzPVIh|ryP M3;rTXNCVkeHUh?=
CMK cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVi4TVI{UW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyOzJ|IN88US=> M3TmZ3NCVkeHUh?=
COLO-829 cell MkPYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV3XU3pVUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPMVgzQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwMkSyNlYh|ryP M4mxW3NCVkeHUh?=
COR-L279 cell NFjicHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{PQTGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVyyO|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB5M{ig{txO Mly0V2FPT0WU
CP66-MEL cell MoP1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXGe3JKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwNUS5O{DPxE1? NIPpemZUSU6JRWK=
CRO-AP2 cell NVrRSXhGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWCxToZFUW6qaXLpeIlwdiCxZjDoeY1idiCFUl:tRXAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|NkC4PEDPxE1? MXjTRW5ITVJ?
CTV-1 cell M3HiWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{DWUGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46OTR3IN88US=> NFTTO3JUSU6JRWK=
Calu-6 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXzTY5pcWKrdHnvckBw\iCqdX3hckBE[Wy3LU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{42QDZizszN MXzTRW5ITVJ?
D-247MG cell MoXGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTPOlE1UW6qaXLpeIlwdiCxZjDoeY1idiCGLUK0O21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54MkixOEDPxE1? M1fjN3NCVkeHUh?=
D-263MG cell MoPuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA5PTB7IN88US=> M{HCTXNCVkeHUh?=
D-336MG cell NUTFSI5bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmfmTY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh3NDFOwG0> MlTyV2FPT0WU
D-392MG cell NWPndo9nT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYnvNIhMUW6qaXLpeIlwdiCxZjDoeY1idiCGLUO5Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS52M{CzPUDPxE1? MVnTRW5ITVJ?
D-502MG cell NI\PRZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkfwTY5pcWKrdHnvckBw\iCqdX3hckBFNTVyMl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE42OzR7MjFOwG0> NIO4SolUSU6JRWK=
D-542MG cell MlvPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGQuPTR{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4{OTV{IN88US=> MWfTRW5ITVJ?
DB cell MlLFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NW\6SWNlUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3MlE1OTdizszN NVLRNG52W0GQR1XS
DEL cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmjLTY5pcWKrdHnvckBw\iCqdX3hckBFTUxiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkCxPFk5KM7:TR?= NHXXfpZUSU6JRWK=
DMS-114 cell Mkn4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFi4UlBKdmirYnn0bY9vKG:oIHj1cYFvKESPUz2xNVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01QS56NE[4JO69VQ>? Mni0V2FPT0WU
DMS-153 cell Ml\IS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzUTY5pcWKrdHnvckBw\iCqdX3hckBFVVNvMUWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvQTl{MzFOwG0> MVHTRW5ITVJ?
DOHH-2 cell NWD3[VAyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PjRizszN M3SzenNCVkeHUh?=
DSH1 cell NF;TWVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYnJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkSzOlI{KM7:TR?= NEC0WodUSU6JRWK=
Daudi cell M1TmWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MljSTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFk5ODJizszN MV3TRW5ITVJ?
EC-GI-10 cell NEntbHFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1vpWGlvcGmkaYTpc44hd2ZiaIXtZY4hTUNvR1mtNVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PC5{NUi5JO69VQ>? M2jqTnNCVkeHUh?=
ECC4 cell M{Hqc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{DOeGlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOyMlE5QTZizszN MYHTRW5ITVJ?
EM-2 cell MkDDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3G2W2lvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFU2QTRizszN MX3TRW5ITVJ?
ES1 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjCTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkW0NFg4KM7:TR?= MnL4V2FPT0WU
ES3 cell NITaXFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTCTY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Mj60O|I6KM7:TR?= NEL6RXhUSU6JRWK=
ES4 cell NH7vWYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn:0TY5pcWKrdHnvckBw\iCqdX3hckBGWzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|NT6xPVUh|ryP NVHHZVA4W0GQR1XS
ES6 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGVUPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMkS3N|Mh|ryP MlHOV2FPT0WU
ES7 cell M1nxOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHVeVhTUW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlI{OTJ2IN88US=> NVrzNW5zW0GQR1XS
ES8 cell MkDxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH;NU4tKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFE6OjRizszN NWq5[5g6W0GQR1XS
EW-18 cell NX\FWFdPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlc2QSEQvF2= MlT1V2FPT0WU
EW-22 cell NFu1fmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2qyVGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{44QTR5IN88US=> MknFV2FPT0WU
GCIY cell Mn;pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUTsbooyUW6qaXLpeIlwdiCxZjDoeY1idiCJQ1nZJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU45ODN6OTFOwG0> MVnTRW5ITVJ?
GDM-1 cell NHr2bmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUDyfFN6UW6qaXLpeIlwdiCxZjDoeY1idiCJRF2tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvOzlzOU[g{txO MWPTRW5ITVJ?
GI-1 cell NXzzdGhbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVPJcohq[mm2aX;uJI9nKGi3bXHuJGdKNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwOVI{KM7:TR?= M1vPSnNCVkeHUh?=
GI-ME-N cell MnrrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{CzV2lvcGmkaYTpc44hd2ZiaIXtZY4hT0lvTVWtUkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvODR7NUGg{txO MXzTRW5ITVJ?
GR-ST cell M{PnOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWnJcohq[mm2aX;uJI9nKGi3bXHuJGdTNVOWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|kxOiEQvF2= MVnTRW5ITVJ?
GT3TKB cell M2fESmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7QTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxOzh7IN88US=> NFnOVZlUSU6JRWK=
HAL-01 cell NEm2cpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1e5[2lvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QTdzMjFOwG0> NEDLc3VUSU6JRWK=
HCC1599 cell NWe1SoFjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLz[3ZWUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxOVk6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzdwNkCxNUDPxE1? NIPBNIZUSU6JRWK=
HCC2218 cell MkjoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGhESzJ{MUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{QDN2IN88US=> NHz6ZZpUSU6JRWK=
HD-MY-Z cell NY\DZ|lNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUHDZlVtUW6qaXLpeIlwdiCxZjDoeY1idiCKRD3NXU1bKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwMkG0OkDPxE1? NWG1cIpoW0GQR1XS
HL-60 cell NEDKWHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M13QcGlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk4zOTF2IN88US=> M1jyeXNCVkeHUh?=
HOP-62 cell MoTNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NULHbIhjUW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtOlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy57NUK3JO69VQ>? M3jWdnNCVkeHUh?=
HT cell NI\SOVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml;lTY5pcWKrdHnvckBw\iCqdX3hckBJXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNESzNlEh|ryP Mn3GV2FPT0WU
HT-144 cell NHP3Z3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlS2TY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlkxPjh4IN88US=> NX\3OlhbW0GQR1XS
HUTU-80 cell NH7GfWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHGTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{44QDl6NjFOwG0> MoTBV2FPT0WU
IST-MEL1 cell NWDYWlNrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2PCdGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi57MEi2JO69VQ>? MYrTRW5ITVJ?
IST-SL1 cell Ml\JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1nw[GlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTdyN{mg{txO MofsV2FPT0WU
IST-SL2 cell M1\5eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mny3TY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPjZyODFOwG0> MmT6V2FPT0WU
K052 cell NWnEeYl{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEfpWpZKdmirYnn0bY9vKG:oIHj1cYFvKEtyNUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc2OzBzIN88US=> M1vXSnNCVkeHUh?=
K5 cell NFW0foNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGs2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwNUmxOUDPxE1? NYjzN3M6W0GQR1XS
KALS-1 cell MonoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGtCVFNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK5MlM6PjlizszN NHXXWm1USU6JRWK=
KARPAS-422 cell NHXBW3pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGS3V5lKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01OjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Mj65NVQzKM7:TR?= NV;scndNW0GQR1XS
KARPAS-45 cell NVPHbGFNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXu5N|lCUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkGxNlQ4KM7:TR?= NHP1U5FUSU6JRWK=
KE-37 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT64N|Uh|ryP M1GyfXNCVkeHUh?=
KG-1 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYPJcohq[mm2aX;uJI9nKGi3bXHuJGtINTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mz65O|U4KM7:TR?= NXS2clA2W0GQR1XS
KGN cell MoqxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFLaXGxKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVY4PDJizszN NHO5cHdUSU6JRWK=
KM12 cell MkLlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoW2TY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz61Nlk3PCEQvF2= NF3sd|lUSU6JRWK=
KMOE-2 cell Mo\MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\WPYNYUW6qaXLpeIlwdiCxZjDoeY1idiCNTV;FMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{OC52NUS5JO69VQ>? NVS2W49RW0GQR1XS
KNS-42 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGTZfmdKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvQDF7MUWg{txO M4Lw[nNCVkeHUh?=
KNS-81-FD cell NXnnTHV1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\o[ohKdmirYnn0bY9vKG:oIHj1cYFvKEuQUz24NU1HTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN5LkSyOkDPxE1? NEHXc|hUSU6JRWK=
KS-1 cell NIrYVGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mk\1TY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFQ3KM7:TR?= MXXTRW5ITVJ?
KU812 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEmyS4dKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvPDh2IN88US=> NViwZXhUW0GQR1XS
L-540 cell M1nPU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkftTY5pcWKrdHnvckBw\iCqdX3hckBNNTV2MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKwMlc1PDVizszN MUjTRW5ITVJ?
LAMA-84 cell M324Z2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJGxCVUFvOESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43PzR{IN88US=> NHr1S5RUSU6JRWK=
LB1047-RCC cell NXKyZYYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPZSZFKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6zPFg{KM7:TR?= NIXvemJUSU6JRWK=
LB2241-RCC cell NIrZZnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnS5TY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNUWzOkDPxE1? MWLTRW5ITVJ?
LB2518-MEL cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjdzNEm2{txO NVfQU5UxW0GQR1XS
LB831-BLC cell NHLUZ4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHO2VYFKdmirYnn0bY9vKG:oIHj1cYFvKEyEOEOxMWJNSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkG3NlYh|ryP M2rxNHNCVkeHUh?=
LB996-RCC cell NHPyVFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml2xTY5pcWKrdHnvckBw\iCqdX3hckBNSjl7Nj3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi55NEOxJO69VQ>? M1HzSXNCVkeHUh?=
LC4-1 cell NV:1UWlnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHKWHJKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvQDN2MTFOwG0> NELRXnhUSU6JRWK=
LOUCY cell NVTZ[41tT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{WyW2lvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2Ojd4IN88US=> M{Phe3NCVkeHUh?=
LOXIMVI cell NGjNdnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE4zOTJ{IN88US=> NG\hR|RUSU6JRWK=
LS-123 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LNdGlvcGmkaYTpc44hd2ZiaIXtZY4hVFNvMUKzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjJ3ODFOwG0> MXrTRW5ITVJ?
LU-134-A cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1nxVmlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO0MWEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjF2ME[4JO69VQ>? Mo\XV2FPT0WU
LU-139 cell NWHobFFpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX;3boljUW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi5{MUig{txO NFO1VXdUSU6JRWK=
LXF-289 cell NHjHb3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3TjPGlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE4NjR|NUJOwG0> M4fr[XNCVkeHUh?=
MC116 cell Mn\CS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MniwTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1MlA5PDFizszN MkCxV2FPT0WU
MDA-MB-134-VI cell Mkm0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITHXZlKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk0yOzRvVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4zPDh4IN88US=> MkPRV2FPT0WU
MFH-ino cell M3H1fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3mN3FZUW6qaXLpeIlwdiCxZjDoeY1idiCPRlitbY5wKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54NEO4N{DPxE1? NYfoTpRoW0GQR1XS
MHH-NB-11 cell M1T4RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkizTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvTlKtNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB4Nkmg{txO NEXYPYpUSU6JRWK=
ML-2 cell M1nyTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4XUUWlvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOFA{ODRizszN NF\KPVRUSU6JRWK=
MOLT-13 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYO4TW1WUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC52M{[1N{DPxE1? M4ThVHNCVkeHUh?=
MOLT-16 cell M3rDb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfFXmdwUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zMUG2N{DPxE1? Mo\OV2FPT0WU
MOLT-4 cell NFLOWpBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jtZWlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPDF{NDFOwG0> NXP1WZV5W0GQR1XS
MPP-89 cell NEC4cHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnW4TY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI2QTJ{IN88US=> NH\yVZRUSU6JRWK=
MRK-nu-1 cell NGLDSnRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;6TY5pcWKrdHnvckBw\iCqdX3hckBOWktvboWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTd3N{Kg{txO NH;LTVRUSU6JRWK=
MSTO-211H cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnDOoYyUW6qaXLpeIlwdiCxZjDoeY1idiCPU2TPMVIyOUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64Olkh|ryP MVPTRW5ITVJ?
MV-4-11 cell MorRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE{QTF3IN88US=> NGTSTWtUSU6JRWK=
NALM-6 cell M4TDcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVYyODlizszN M4n4bnNCVkeHUh?=
NB1 cell NIPabWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4rqe2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64OFM3QSEQvF2= MmK1V2FPT0WU
NB10 cell M1LyRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HBfGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVM6OTVizszN MYXTRW5ITVJ?
NB12 cell NY\qZWNnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrXNZlsUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvPTZ3NjFOwG0> NIOz[2hUSU6JRWK=
NB13 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrYV3BKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMyOjd6IN88US=> MYDTRW5ITVJ?
NB17 cell M2HFc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\tXllTUW6qaXLpeIlwdiCxZjDoeY1idiCQQkG3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{42QDB3MTFOwG0> MkXtV2FPT0WU
NB6 cell MlTlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUmxNVQh|ryP Mlf2V2FPT0WU
NCCIT cell NIfvNo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXj3O5lWUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQyNjh2NUOg{txO MojoV2FPT0WU
NCI-H1155 cell NFvYfWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEiwPWpKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVE2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF2LkO0NFgh|ryP M3T6XXNCVkeHUh?=
NCI-H1304 cell M4DKN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUOwOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjh7OEKg{txO NEO3PI1USU6JRWK=
NCI-H1355 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnHDTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGzOVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njl2MUGg{txO MXHTRW5ITVJ?
NCI-H1395 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlnLTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGzPVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOi56N{m1JO69VQ>? NWjOXHl3W0GQR1XS
NCI-H1417 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVTEOHFJUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE1OTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lk[3OVIzKM7:TR?= M4q0dHNCVkeHUh?=
NCI-H1436 cell MoCxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3TQemlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOFM3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56NEGwNUDPxE1? MX;TRW5ITVJ?
NTERA-S-cl-D1 cell NHjq[4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmj5TY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuPFk{PSEQvF2= NX7YU3NoW0GQR1XS
JiyoyeP-2003 cell M3HUTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2TJ[GlvcGmkaYTpc44hd2ZiaIXtZY4hUmm7b4nlVE0zODB|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{[uOlI5PCEQvF2= MV7TRW5ITVJ?

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In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: female Wistar rats
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Ethanol 6 mg/mL (9.88 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 2095432-71-4
Storage powder
in solvent
Synonyms GSK269962B, GSK269962, GSK 269962
Smiles CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID