GSK269962A HCl

For research use only.

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

4 publications

GSK269962A HCl Chemical Structure

CAS No. 2095432-71-4

GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

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Selleck's GSK269962A HCl has been cited by 4 publications

Purity & Quality Control

Choose Selective ROCK Inhibitors

Biological Activity

Description GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NFexPXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmTnTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG1PFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQC56NEe3JO69VQ>? MXXTRW5ITVJ?
NCI-H1694 MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGLJeodKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY6PCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lki3OFkh|ryP MlHLV2FPT0WU
NCI-H1963 MmjXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUm2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd6M{mg{txO M3TaenNCVkeHUh?=
NCI-H2081 NIrlXGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC4NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjZyNESg{txO Mm\GV2FPT0WU
NCI-H209 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHLTVpNKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlA6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwNkK3NkDPxE1? M3LpdHNCVkeHUh?=
NCI-H2107 MkmzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGwO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI2NjZ3NkGg{txO NFn1XodUSU6JRWK=
NCI-H2126 M4nLVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPTB2Mk[g{txO M1\3VnNCVkeHUh?=
NCI-H2171 NGj1Wo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnETY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKxO|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl3OUO3JO69VQ>? M1ftdnNCVkeHUh?=
NCI-H2227 NF2zNnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fSeGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNlI4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py56OE[xOkDPxE1? M{fFOXNCVkeHUh?=
NCI-H524 NH\qZYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHzT[|RKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwOEe2N{DPxE1? NEXJT|VUSU6JRWK=
NCI-H526 NFjyNVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mkf2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjV2M{Gg{txO MnHHV2FPT0WU
NCI-H720 MnvSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41PTF4MTFOwG0> MVnTRW5ITVJ?
NMC-G1 Ml;PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2TvR2lvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvODV5ODFOwG0> MoDaV2FPT0WU
NOS-1 cell M3rh[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUm4OZM2UW6qaXLpeIlwdiCxZjDoeY1idiCQT2OtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDJ{OUSg{txO NV\XWGN5W0GQR1XS
OCI-AML2 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEfv[oNKdmirYnn0bY9vKG:oIHj1cYFvKE:FST3BUWwzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwOUS5OkDPxE1? MkPmV2FPT0WU
OCUB-M cell NEKyWJhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWnJcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlIxOSEQvF2= NY\LcpJyW0GQR1XS
ONS-76 cell M3\0fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jxRWlvcGmkaYTpc44hd2ZiaIXtZY4hV06VLUe2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQTF7MTFOwG0> MlGxV2FPT0WU
OS-RC-2 cell NGrPfnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEH1cnRKdmirYnn0bY9vKG:oIHj1cYFvKE:VLWLDMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Pi5zOUWg{txO MXfTRW5ITVJ?
OVCAR-4 cell NHHM[mZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHK3OG1KdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdzOEC4JO69VQ>? NWDrNZY5W0GQR1XS
P30-OHK cell NIDBRVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlYzQDd5IN88US=> NEG5T3ZUSU6JRWK=
P30-OHK cell MoPmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNFQ6PTRizszN MnjlV2FPT0WU
PSN1 cell NX\KUpRqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1n0RWlvcGmkaYTpc44hd2ZiaIXtZY4hWFOQMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uNlIyOjZizszN NGfiS3FUSU6JRWK=
QIMR-WIL cell MoXKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTByNDFOwG0> MVXTRW5ITVJ?
RCC10RGB cell MkHWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIO4SWFKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOUCzOkDPxE1? M1XqTXNCVkeHUh?=
RKO cell NELF[nRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTQTY5pcWKrdHnvckBw\iCqdX3hckBTU09iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OlYzKM7:TR?= M2XR[HNCVkeHUh?=
RL95-2 cell NEDUT3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPrVllKdmirYnn0bY9vKG:oIHj1cYFvKFKOOUWtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ5IN88US=> NGf3Oo1USU6JRWK=
RPMI-6666 cell M1P2Nmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvNk[2OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5NjV{M{[g{txO Mk[yV2FPT0WU
RPMI-8402 cell NVPEZo1uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYr0[ohJUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVg1ODJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW4OVYh|ryP MYXTRW5ITVJ?
RXF393 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4e5OmlvcGmkaYTpc44hd2ZiaIXtZY4hWliIM{mzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{QTNizszN NEjEeYlUSU6JRWK=
Ramos-2G6-4C10 cell NUm5ZXNLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOVch|ryP M4H6PHNCVkeHUh?=
SCLC-21H cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGTmZo5KdmirYnn0bY9vKG:oIHj1cYFvKFOFTFOtNlFJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54MUG0PUDPxE1? NFTLVJJUSU6JRWK=
SF126 cell Mn7DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVPJcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuPFMzOc7:TR?= M4XzWXNCVkeHUh?=
SF268 cell NWrtb2huT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWPJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjZ6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6yN|E5OyEQvF2= MnzHV2FPT0WU
SF539 cell NUC3eWpYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHTlWIRKdmirYnn0bY9vKG:oIHj1cYFvKFOINUO5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQDZ4MTFOwG0> MXjTRW5ITVJ?
SH-4 cell M1XXeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFT5T4hKdmirYnn0bY9vKG:oIHj1cYFvKFOKLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlc2PTB6IN88US=> NUP2[pBZW0GQR1XS
SIG-M5 cell NUjBVnQ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIfxcHRKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd{NUmg{txO MnHZV2FPT0WU
SJSA-1 cell MlnsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rlWGlvcGmkaYTpc44hd2ZiaIXtZY4hW0qVQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPDV{NjFOwG0> MYnTRW5ITVJ?
SK-LMS-1 cell MknoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mm\MTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OTWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjV7NkWg{txO MkLBV2FPT0WU
SK-MM-2 cell NEDMS21Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnvOTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvOzRyNTFOwG0> MXzTRW5ITVJ?
SK-N-DZ cell NUPvbYxOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHm4So9KdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjR6M{G0JO69VQ>? MoTRV2FPT0WU
SK-NEP-1 cell M3S1dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPTR3NjFOwG0> NUfzToY1W0GQR1XS
SK-PN-DW cell M33aOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHkTY5pcWKrdHnvckBw\iCqdX3hckBUUy2STj3EW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1Njl5M{[g{txO MVPTRW5ITVJ?
SNB75 cell M1LPTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wO|c{PyEQvF2= NV;2PJBmW0GQR1XS
SR cell NEH5cpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWDJcohq[mm2aX;uJI9nKGi3bXHuJHNTKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMECxN|ch|ryP Mk[4V2FPT0WU
SU-DHL-1 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHNWNUSKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvPzN|NjFOwG0> NHzKPFJUSU6JRWK=
SW684 cell Ml7MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4G0d2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4xOTFizszN M4m5OXNCVkeHUh?=
SW872 cell NHHuZVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnPXTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg3PTZizszN NGjjN5pUSU6JRWK=
SW962 cell MlrqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoDwTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlc2OjFizszN MnTOV2FPT0WU
697 cell NUDTV5JJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFrDXohKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlk6OSEQvF2= NIG0cYdUSU6JRWK=
8-MG-BA cell NYTpRnhET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWO1NVk6UW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjNwMEe5N{DPxE1? MoXZV2FPT0WU
A101D cell M3y5TWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkjrTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFcxOzRizszN MX;TRW5ITVJ?
ACN cell NWjabWJUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFHHOFJKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlQ{QDdizszN NIHNe5pUSU6JRWK=
AM-38 cell NFvxZnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{TyZWlvcGmkaYTpc44hd2ZiaIXtZY4hSU1vM{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlI3OzJ5IN88US=> NVnafJhuW0GQR1XS
ATN-1 cell M1zofWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkSuO|U2PSEQvF2= NE\EPZRUSU6JRWK=
BB30-HNC cell NFzPdFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVvJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjV|MjFOwG0> MUjTRW5ITVJ?
BB49-HNC cell M1XPbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLs[VdKdmirYnn0bY9vKG:oIHj1cYFvKEKENEmtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMEe4PUDPxE1? MnzmV2FPT0WU
human BC-1 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXLIdW9QUW6qaXLpeIlwdiCxZjDoeY1idiCEQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{46PzFyNzFOwG0> NXSyTI5lW0GQR1XS
BE-13 cell Ml7FS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOFA5Oc7:TR?= MmTaV2FPT0WU
BL-70 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1HlXWlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQxPzB|IN88US=> MYjTRW5ITVJ?
BV-173 cell M3Ha[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M37l[GlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvQDh3OTFOwG0> NH7DVHJUSU6JRWK=
Becker cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIP3VmxKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl3NEWg{txO MX\TRW5ITVJ?
CAL-148 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NI\iZZhKdmirYnn0bY9vKG:oIHj1cYFvKEODTD2xOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PS54NUW3JO69VQ>? MYfTRW5ITVJ?
TE-10 cell NFHRb2tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHOTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKyMlg1OjNizszN NELnZppUSU6JRWK=
TE-12 cell NHXjVZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1HaZmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk41OTF2IN88US=> NXW2fXg6W0GQR1XS
TE-8 cell NVGyfnZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NULJOFZXUW6qaXLpeIlwdiCxZjDoeY1idiCWRT24JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB6OTFOwG0> M1zJfXNCVkeHUh?=
TE-9 cell NYTZSGxET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnTnTY5pcWKrdHnvckBw\iCqdX3hckBVTS17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{[uOlM5OSEQvF2= MknRV2FPT0WU
TGW cell M3H2dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NG\0U45KdmirYnn0bY9vKG:oIHj1cYFvKFSJVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlM2PzdizszN MUfTRW5ITVJ?
UACC-257 cell M{KxTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnTTTY5pcWKrdHnvckBw\iCqdX3hckBWSUOFLUK1O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPzB4MkWg{txO MmTwV2FPT0WU
WSU-NHL cell M2nwO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPSTY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlcvOTlyNzFOwG0> NXvTWWU1W0GQR1XS
no-10 cell MoXqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmX1TY5pcWKrdHnvckBw\iCqdX3hckBvdy1zMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlY5PDZizszN M3TmNnNCVkeHUh?=
no-11 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M173dWlvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20O{4xOjZ|IN88US=> NYq1O4RyW0GQR1XS
CAS-1 cell NU\DOoRiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fRTGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1PyEQvF2= NYj5OmNCW0GQR1XS
CCRF-CEM cell MmLXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M36w[mlvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjZ3M{myJO69VQ>? NV;PUXA3W0GQR1XS
CMK cell NUDqVZN5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYm5PZF1UW6qaXLpeIlwdiCxZjDoeY1idiCFTVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyOzJ|IN88US=> MorOV2FPT0WU
COLO-829 cell MkTuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnMWGlKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFI6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy5{NEKyOkDPxE1? NYjiPXBUW0GQR1XS
COR-L279 cell Mn\hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OMke5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPzN6IN88US=> NXjidIpyW0GQR1XS
CP66-MEL cell Mn6wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEP2UXlKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwNUS5O{DPxE1? MX7TRW5ITVJ?
CRO-AP2 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlfRTY5pcWKrdHnvckBw\iCqdX3hckBEWk9vQWCyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PjB6ODFOwG0> M{nhR3NCVkeHUh?=
CTV-1 cell M2\6[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFL3UpdKdmirYnn0bY9vKG:oIHj1cYFvKEOWVj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvQTF2NTFOwG0> M2fFeHNCVkeHUh?=
Calu-6 cell Mn25S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVy1XWF{UW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Py53OE[g{txO MlGzV2FPT0WU
D-247MG cell M2Dr[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFPQ[5dKdmirYnn0bY9vKG:oIHj1cYFvKERvMkS3UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjZ{OEG0JO69VQ>? MorzV2FPT0WU
D-263MG cell NXHEdo9zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mkj6TY5pcWKrdHnvckBw\iCqdX3hckBFNTJ4M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xQDVyOTFOwG0> M{fPUXNCVkeHUh?=
D-336MG cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIXQ[YpKdmirYnn0bY9vKG:oIHj1cYFvKERvM{O2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjZ{OEW0JO69VQ>? NV\IWmd6W0GQR1XS
D-392MG cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1\JUWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1|OULNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDNyM{mg{txO NWC0fY1SW0GQR1XS
D-502MG cell M{XVO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nJN2lvcGmkaYTpc44hd2ZiaIXtZY4hTC13MELNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTN2OUKg{txO NIXlWnRUSU6JRWK=
D-542MG cell NFHrWYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHf0SFRKdmirYnn0bY9vKG:oIHj1cYFvKERvNUSyUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi5|MUWyJO69VQ>? NWjZNGRnW0GQR1XS
DB cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3\rTmlvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Nz6xOFE4KM7:TR?= MUjTRW5ITVJ?
DEL cell M{jCXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMEG4PVgh|ryP NVyxfZFmW0GQR1XS
DMS-114 cell MmHXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGROWy1zMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20PU45PDZ6IN88US=> NGmzeWtUSU6JRWK=
DMS-153 cell NXnUWmNzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\TTmxNUW6qaXLpeIlwdiCxZjDoeY1idiCGTWOtNVU{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwOUmyN{DPxE1? M{G1OnNCVkeHUh?=
DOHH-2 cell NV\1RWJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm[wTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzZ2IN88US=> MX3TRW5ITVJ?
DSH1 cell NILGTWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWrJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkSzOlI{KM7:TR?= NVjudI57W0GQR1XS
Daudi cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXq5TldwUW6qaXLpeIlwdiCxZjDoeY1idiCGYYXkbUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODl6MEKg{txO M4L3S3NCVkeHUh?=
EC-GI-10 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1vyO2lvcGmkaYTpc44hd2ZiaIXtZY4hTUNvR1mtNVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01PC5{NUi5JO69VQ>? M4\zWXNCVkeHUh?=
ECC4 cell M4HL[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGTic|VKdmirYnn0bY9vKG:oIHj1cYFvKEWFQ{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk4yQDl4IN88US=> NEfRbGZUSU6JRWK=
EM-2 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUezZnFDUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41PTV7NDFOwG0> MXvTRW5ITVJ?
ES1 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNUSwPFch|ryP Mo\MV2FPT0WU
ES3 cell MlO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXf1RlRWUW6qaXLpeIlwdiCxZjDoeY1idiCHU{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20Nk41PzJ7IN88US=> NYPuPY9vW0GQR1XS
ES4 cell NFHhU3VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGVUPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN3LkG5OUDPxE1? MmWxV2FPT0WU
ES6 cell MmHhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI\WTWZKdmirYnn0bY9vKG:oIHj1cYFvKEWVNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlQ4OzNizszN NVnGTY1mW0GQR1XS
ES7 cell M3v5[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPlTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkKzNVI1KM7:TR?= NV7UeW1LW0GQR1XS
ES8 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlrjTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkixPVI1KM7:TR?= MXHTRW5ITVJ?
EW-18 cell MmqwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;nPWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43PzV7IN88US=> NUTLVnlEW0GQR1XS
EW-22 cell M{nnT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmnWTY5pcWKrdHnvckBw\iCqdX3hckBGXy1{MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3Mlc6PDdizszN M4XnWHNCVkeHUh?=
GCIY cell NHLMcYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkiwN|g6KM7:TR?= MUXTRW5ITVJ?
GDM-1 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXvTY5pcWKrdHnvckBw\iCqdX3hckBITE1vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuN|kyQTZizszN MVXTRW5ITVJ?
GI-1 cell MnfkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFjUcYtKdmirYnn0bY9vKG:oIHj1cYFvKEeLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlAxPTJ|IN88US=> Mnr0V2FPT0WU
GI-ME-N cell MlLTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MofZTY5pcWKrdHnvckBw\iCqdX3hckBIUS2PRT3OJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xPDl3MTFOwG0> MoLEV2FPT0WU
GR-ST cell NXWy[XJZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGdTNVOWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|kxOiEQvF2= M4\MfHNCVkeHUh?=
GT3TKB cell NXftZpZ{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYLpWGRiUW6qaXLpeIlwdiCxZjDoeY1idiCJVEPUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZyM{i5JO69VQ>? MoPiV2FPT0WU
HAL-01 cell NUnH[GpUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M17zbmlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QTdzMjFOwG0> NYTFR5B7W0GQR1XS
HCC1599 cell M2D6O2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJGhESzF3OUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zO{43ODFzIN88US=> MlPyV2FPT0WU
HCC2218 cell M1zsO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWfJcohq[mm2aX;uJI9nKGi3bXHuJGhESzJ{MUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{QDN2IN88US=> M{PjeXNCVkeHUh?=
HD-MY-Z cell M{XyRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jIbGlvcGmkaYTpc44hd2ZiaIXtZY4hUERvTWmtXkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI2NjJzNE[g{txO NW\KZlJRW0GQR1XS
HL-60 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnrkTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlIyOTRizszN MmLZV2FPT0WU
HOP-62 cell NIPyOXVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3K2SWlvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvQTV{NzFOwG0> NX3RNZJXW0GQR1XS
HT cell NIDoU|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nmVGlvcGmkaYTpc44hd2ZiaIXtZY4hUFRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0N|IyKM7:TR?= NXOwUXBTW0GQR1XS
HT-144 cell NH3hZZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1:1VmlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE46ODZ6NjFOwG0> M4fxcHNCVkeHUh?=
HUTU-80 cell NYe1XFRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4PEN2lvcGmkaYTpc44hd2ZiaIXtZY4hUFWWVT24NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPzh7OE[g{txO M{\SWHNCVkeHUh?=
IST-MEL1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NY\DS5pXUW6qaXLpeIlwdiCxZjDoeY1idiCLU2StUWVNOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN{LkmwPFYh|ryP Mn2wV2FPT0WU
IST-SL1 cell NVrnPIM2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TCdWlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTdyN{mg{txO NYH5Rm5iW0GQR1XS
IST-SL2 cell M16wNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\NXYZKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ4NkC4JO69VQ>? M1[xSXNCVkeHUh?=
K052 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGsxPTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLke1N|AyKM7:TR?= NUPoc3NtW0GQR1XS
K5 cell NUW2NXp{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\mcFVMUW6qaXLpeIlwdiCxZjDoeY1idiCNNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOzMlU6OTVizszN M1:1VXNCVkeHUh?=
KALS-1 cell NHS2c2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJGtCVFNvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK5MlM6PjlizszN NIHlWZJUSU6JRWK=
KARPAS-422 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MofnTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwOUG0NkDPxE1? MnXNV2FPT0WU
KARPAS-45 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVS4T2lzUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkGxNlQ4KM7:TR?= Ml3DV2FPT0WU
KE-37 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1jlNGlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25Mlg{PSEQvF2= MoXrV2FPT0WU
KG-1 cell Ml\kS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFvjNnRKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46PzV5IN88US=> MYfTRW5ITVJ?
KGN cell NVzuW|FXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEnSSnFKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVY4PDJizszN NXrGPJo1W0GQR1XS
KM12 cell NGewUpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF7HZlFKdmirYnn0bY9vKG:oIHj1cYFvKEuPMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlUzQTZ2IN88US=> Mn6zV2FPT0WU
KMOE-2 cell M2\CWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHqTXRKdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjR3NEmg{txO MX7TRW5ITVJ?
KNS-42 cell MofZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVLoT|Y2UW6qaXLpeIlwdiCxZjDoeY1idiCNTmOtOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjhzOUG1JO69VQ>? MmrkV2FPT0WU
KNS-81-FD cell NIfkXIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoH5TY5pcWKrdHnvckBw\iCqdX3hckBMVlNvOEGtSmQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py52Mk[g{txO M3viRnNCVkeHUh?=
KS-1 cell Mnr1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUTJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkCwOFYh|ryP MnzSV2FPT0WU
KU812 cell MoHyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDVTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlQ5PCEQvF2= NU\MTYNsW0GQR1XS
L-540 cell M{\tO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnn1TY5pcWKrdHnvckBw\iCqdX3hckBNNTV2MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKwMlc1PDVizszN NHfQV5RUSU6JRWK=
LAMA-84 cell NHvrZ|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1u1[WlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjZ5NEKg{txO NI\zPJVUSU6JRWK=
LB1047-RCC cell NUPq[XI2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQC5|OEizJO69VQ>? M3\afHNCVkeHUh?=
LB2241-RCC cell M13UVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXjEUWNEUW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVU{PiEQvF2= M4XFU3NCVkeHUh?=
LB2518-MEL cell NFu5fWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmrRTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ3MUitUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MUS5Ou69VQ>? M4S0c3NCVkeHUh?=
LB831-BLC cell M1zMcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEXHTHRKdmirYnn0bY9vKG:oIHj1cYFvKEyEOEOxMWJNSyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkG3NlYh|ryP NXjqRnl1W0GQR1XS
LB996-RCC cell MlvJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTE[ZpDUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj63OFMyKM7:TR?= MmH4V2FPT0WU
LC4-1 cell NUe5[XI4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlnPTY5pcWKrdHnvckBw\iCqdX3hckBNSzRvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOyMlg{PDFizszN Mlv5V2FPT0WU
LOUCY cell MofCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{j3WGlvcGmkaYTpc44hd2ZiaIXtZY4hVE:XQ2mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2Ojd4IN88US=> NXvROGVCW0GQR1XS
LOXIMVI cell MkTNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE4zOTJ{IN88US=> NGr1WpFUSU6JRWK=
LS-123 cell M1HNUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJGxUNTF{MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO5MlIzPThizszN NVvsTWFJW0GQR1XS
LU-134-A cell NEnTbWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zRSWlvcGmkaYTpc44hd2ZiaIXtZY4hVFVvMUO0MWEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjF2ME[4JO69VQ>? NVjlTIpJW0GQR1XS
LU-139 cell NEPaNmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoD4TY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk4zOThizszN M2XLPHNCVkeHUh?=
LXF-289 cell NH25[ZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXncVNrUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNEO1Ne69VQ>? MlPmV2FPT0WU
MC116 cell M{Lx[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3LCbGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNzMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU4xQDRzIN88US=> NHnQ[mlUSU6JRWK=
MDA-MB-134-VI cell NYPaWo9oT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2xN|QuXkliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|OT6yOFg3KM7:TR?= M{KzbXNCVkeHUh?=
MFH-ino cell NFzoemlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGe2PHlKdmirYnn0bY9vKG:oIHj1cYFvKE2ISD3pco8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjZ2M{izJO69VQ>? NIPOPIFUSU6JRWK=
MHH-NB-11 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH72OZZKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3ORk0yOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwME[2PUDPxE1? NIT1e21USU6JRWK=
ML-2 cell MkK3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4i1OGlvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOFA{ODRizszN NWjnWXRFW0GQR1XS
MOLT-13 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ{PjV|IN88US=> Mn3RV2FPT0WU
MOLT-16 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHNZVA{UW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zMUG2N{DPxE1? MkLiV2FPT0WU
MOLT-4 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXjSU4hlUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC52MUK0JO69VQ>? NVvpe3hSW0GQR1XS
MPP-89 cell NV\WSWJxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnzJTY5pcWKrdHnvckBw\iCqdX3hckBOWFBvOEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI2QTJ{IN88US=> NGnEenpUSU6JRWK=
MRK-nu-1 cell NHX1d4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjZTY5pcWKrdHnvckBw\iCqdX3hckBOWktvboWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTd3N{Kg{txO MU\TRW5ITVJ?
MSTO-211H cell M3v4WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWXSfVZFUW6qaXLpeIlwdiCxZjDoeY1idiCPU2TPMVIyOUhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64Olkh|ryP NEi1RYJUSU6JRWK=
MV-4-11 cell NIPie4xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4TUZ2lvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTN7MUWg{txO MX;TRW5ITVJ?
NALM-6 cell MoT1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4fUdmlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42PjFyOTFOwG0> MYLTRW5ITVJ?
NB1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn\YTY5pcWKrdHnvckBw\iCqdX3hckBPSjFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lki0N|Y6KM7:TR?= MYrTRW5ITVJ?
NB10 cell NHTxXnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnXW5l6UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOzlzNTFOwG0> M{Pk[HNCVkeHUh?=
NB12 cell M{\obGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNj61OlU3KM7:TR?= MlznV2FPT0WU
NB13 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFL4c41KdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMyOjd6IN88US=> NVvlU4FSW0GQR1XS
NB17 cell NEjUVGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG5DOTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkW4NFUyKM7:TR?= MlP6V2FPT0WU
NB6 cell NUnXbXZ6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5DPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUmxNVQh|ryP MU\TRW5ITVJ?
NCCIT cell Ml7XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVO1V5hwUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQyNjh2NUOg{txO M1zxN3NCVkeHUh?=
NCI-H1155 cell NEH3d|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3v6NmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwM{SwPEDPxE1? M4nF[3NCVkeHUh?=
NCI-H1304 cell M{LpPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUPLfXlOUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{ODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMT64PVgzKM7:TR?= NF7P[IVUSU6JRWK=
NCI-H1355 cell MnrYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4L0NGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixN|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57NEGxJO69VQ>? MnrFV2FPT0WU
NCI-H1395 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX60O|RVUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE{QTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mj64O|k2KM7:TR?= MoDiV2FPT0WU
NCI-H1417 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYrxRlhbUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE1OTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13Lk[3OVIzKM7:TR?= MoiwV2FPT0WU
NCI-H1436 cell M3j6Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWOwRpByUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE1OzZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lki0NVAyKM7:TR?= MnfRV2FPT0WU
NTERA-S-cl-D1 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEDjeGhKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk45QTN3IN88US=> NGT3[XdUSU6JRWK=
JiyoyeP-2003 cell NHHO[JJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV3mOHZTUW6qaXLpeIlwdiCxZjDoeY1idiCMaYnvfYVRNTJyMEOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk43Ojh2IN88US=> MUTTRW5ITVJ?

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In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol

Cell Research:[1]
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  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: female Wistar rats
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (164.72 mM)
Water Insoluble
Ethanol '6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 2095432-71-4
Storage powder
in solvent
Synonyms GSK269962B, GSK269962, GSK 269962
Smiles CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ROCK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID