GSK269962A HCl

Catalog No.S7687 Synonyms: GSK269962B, GSK269962, GSK 269962

For research use only.

GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

GSK269962A HCl Chemical Structure

CAS No. 2095432-71-4

Selleck's GSK269962A HCl has been cited by 5 Publications

Purity & Quality Control

Choose Selective ROCK Inhibitors

Other ROCK Products

Biological Activity

Description GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Targets
ROCK1 [1]
(Cell-free assay)
ROCK2 [1]
(Cell-free assay)
MSK1 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
1.6 nM 4 nM 49 nM 132 nM
In vitro

GSK269962A completely abolished the actin stress fiber formation induced by angiotensin II in human smooth muscles. Such suppressive effect on actin fiber formation was observed beginning at around 1 μM GSK269962A. GSK269962A induced vasorelaxation in preconstricted rat aorta(tissue baths) with an IC50 of 35 nM. the relaxation induced by GSK269962A is reversible. GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H1581 NXLZe4RUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rZNWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOVgyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwOES3O{DPxE1? MlTrV2FPT0WU
NCI-H1694 MlTzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnLmTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2PVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPC56N{S5JO69VQ>? MlTIV2FPT0WU
NCI-H1963 M1\uUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFnMNIdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMke4N|kh|ryP NIm4[pJUSU6JRWK=
NCI-H2081 MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC4NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjZyNESg{txO Mk[xV2FPT0WU
NCI-H209 MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVvOdlh2UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[yO|Ih|ryP Mm\2V2FPT0WU
NCI-H2107 NYDzR3dbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFTabZpKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlExPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ3Lk[1OlEh|ryP NV:4d|JRW0GQR1XS
NCI-H2126 NF3iT4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\jVI1KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlEzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwNUC0NlYh|ryP NVLEUmw4W0GQR1XS
NCI-H2171 M4LYcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF;qfphKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUW5N|ch|ryP MU\TRW5ITVJ?
NCI-H2227 MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLD[2oyUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIzOjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15Lki4OlE3KM7:TR?= NV3SSJYzW0GQR1XS
NCI-H524 NUi1[nhYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPMT2pKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwOEe2N{DPxE1? M2nXb3NCVkeHUh?=
NCI-H526 MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvPTR|MTFOwG0> MkC1V2FPT0WU
NCI-H720 NVzXWHZ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3\YeWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR3MU[xJO69VQ>? NGX3e2hUSU6JRWK=
NMC-G1 M1nqfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYLYdWRNUW6qaXLpeIlwdiCxZjDoeY1idiCQTVOtS|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5yNUe4JO69VQ>? NVS4TpV6W0GQR1XS
NOS-1 cell Mlf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEHqRY9KdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45OjJ7NDFOwG0> MnTiV2FPT0WU
OCI-AML2 cell M1TtRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF3YfmdKdmirYnn0bY9vKG:oIHj1cYFvKE:FST3BUWwzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwOUS5OkDPxE1? MmPFV2FPT0WU
OCUB-M cell NEGyXI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4K4RmlvcGmkaYTpc44hd2ZiaIXtZY4hV0OXQj3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvOjBzIN88US=> NHH0VFZUSU6JRWK=
ONS-76 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVr1NpR5UW6qaXLpeIlwdiCxZjDoeY1idiCRTmOtO|Yh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57MUmxJO69VQ>? M1rnWHNCVkeHUh?=
OS-RC-2 cell NVHke2tST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3HtUmlvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ3NjF7NTFOwG0> MlHZV2FPT0WU
OVCAR-4 cell NFTnXFFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlcyQDB6IN88US=> NYjsVZp5W0GQR1XS
P30-OHK cell NVS4U25RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFy1doVKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjZ{OEe3JO69VQ>? MVfTRW5ITVJ?
P30-OHK cell NWXwTYo6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M33tdGlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{4xPDl3NDFOwG0> NFHpbndUSU6JRWK=
PSN1 cell M1j0OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXIdFVOUW6qaXLpeIlwdiCxZjDoeY1idiCSU16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4zOjF{NjFOwG0> MVnTRW5ITVJ?
QIMR-WIL cell NGnZZWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVXJcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41QTByNDFOwG0> MV7TRW5ITVJ?
RCC10RGB cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKGi3bXHuJHJESzFyUlfCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVgvQTB|NjFOwG0> NIHHW2pUSU6JRWK=
RKO cell MkjTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTqXHhKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlU3PjJizszN MV7TRW5ITVJ?
RL95-2 cell M{ewbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjxd5hKdmirYnn0bY9vKG:oIHj1cYFvKFKOOUWtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ5IN88US=> NVjGS3Q5W0GQR1XS
RPMI-6666 cell M16xdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYXoXGl{UW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVY3PjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOD61NlM3KM7:TR?= NGLxdVZUSU6JRWK=
RPMI-8402 cell MmrGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrZWohKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFQxOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwNUi1OkDPxE1? NHj6b3VUSU6JRWK=
RXF393 cell M{T5U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV;OS|NNUW6qaXLpeIlwdiCxZjDoeY1idiCUWF[zPVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjN7MzFOwG0> Ml71V2FPT0WU
Ramos-2G6-4C10 cell NV3QOWhCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUTucpNMUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzV5IN88US=> M2fEWnNCVkeHUh?=
SCLC-21H cell NX3tRoRHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXy1NVlVUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1zDMVIyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkGxOFkh|ryP M{K3fXNCVkeHUh?=
SF126 cell Ml61S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7i[VlIUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjh|MkJOwG0> NH60[GJUSU6JRWK=
SF268 cell NXzLOW5VT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnHJTY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uNlMyQDNizszN Mom4V2FPT0WU
SF539 cell NVzBfpd[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\iZmQzUW6qaXLpeIlwdiCxZjDoeY1idiCVRkWzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjh4NkGg{txO NHrzc|VUSU6JRWK=
SH-4 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnLeHV[UW6qaXLpeIlwdiCxZjDoeY1idiCVSD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU44PTVyODFOwG0> Mkn3V2FPT0WU
SIG-M5 cell NVGweXFVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjs[VFKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd{NUmg{txO M1fTdnNCVkeHUh?=
SJSA-1 cell NEC1OVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzmPXgyUW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB2NUK2JO69VQ>? MWnTRW5ITVJ?
SK-LMS-1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LSb2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi53OU[1JO69VQ>? MVHTRW5ITVJ?
SK-MM-2 cell NX7vV5o1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVn5VXZWUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NUU0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwM{SwOUDPxE1? M1PBbnNCVkeHUh?=
SK-N-DZ cell NHLaR3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrKcoRKdmirYnn0bY9vKG:oIHj1cYFvKFONLV6tSHoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjR6M{G0JO69VQ>? M{TyV3NCVkeHUh?=
SK-NEP-1 cell M1TZZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\FZ2xKdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNUS1OkDPxE1? NX3ySppwW0GQR1XS
SK-PN-DW cell NHO5[YFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXrEemlVUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3QUk1FXyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ2Lkm3N|Yh|ryP M3zxNXNCVkeHUh?=
SNB75 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjHXW5KdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzd|NzFOwG0> Mnn5V2FPT0WU
SR cell NX;ZWFRwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnSXItKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFAyOzdizszN NG[0eZZUSU6JRWK=
SU-DHL-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnfxTY5pcWKrdHnvckBw\iCqdX3hckBUXS2GSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjd|M{[g{txO Mlv6V2FPT0WU
SW684 cell NUnnUGZWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYfGWYRiUW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjBzMTFOwG0> Mn7xV2FPT0WU
SW872 cell M2n1Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXzTY5pcWKrdHnvckBw\iCqdX3hckBUXzh5MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFg3PTZizszN MWXTRW5ITVJ?
SW962 cell M4XDPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlTxTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlc2OjFizszN NEKxV3hUSU6JRWK=
697 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1O0VGlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPVkyKM7:TR?= MXHTRW5ITVJ?
8-MG-BA cell MlfRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUXJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{4xPzl|IN88US=> NVn1eYo2W0GQR1XS
A101D cell NG\nU2RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlvFTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFcxOzRizszN MoLFV2FPT0WU
ACN cell NV7Jd49rT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFjBV2dKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlQ{QDdizszN M3TwfXNCVkeHUh?=
AM-38 cell Mn7uS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\ucINEUW6qaXLpeIlwdiCxZjDoeY1idiCDTT2zPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOjZ|Mkeg{txO M3vubHNCVkeHUh?=
ATN-1 cell NILYTIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrjb3BKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlQvPzV3NTFOwG0> MmX6V2FPT0WU
BB30-HNC cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NILQfGxKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwMkWzNkDPxE1? NGezNJhUSU6JRWK=
BB49-HNC cell NHXkSI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfJcmhKdmirYnn0bY9vKG:oIHj1cYFvKEKENEmtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMEe4PUDPxE1? M{HUUnNCVkeHUh?=
human BC-1 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lkm3NVA4KM7:TR?= MkXsV2FPT0WU
BE-13 cell NFftZY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnwNZRFUW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTRyOEJOwG0> NUewPXB[W0GQR1XS
BL-70 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrwdZhKUW6qaXLpeIlwdiCxZjDoeY1idiCETD23NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPDB5MEOg{txO NUXhUmZ6W0GQR1XS
BV-173 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjlbnFKdmirYnn0bY9vKG:oIHj1cYFvKEKYLUG3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE5Njh6NUmg{txO M1XxeXNCVkeHUh?=
Becker cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWfwUJJsUW6qaXLpeIlwdiCxZjDoeY1idiCEZXPr[ZIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57NUS1JO69VQ>? NF\scoxUSU6JRWK=
CAL-148 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1PsVGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUG0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM2NjZ3NUeg{txO MX\TRW5ITVJ?
TE-10 cell NFzlUG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{H4[mlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk45PDJ|IN88US=> NVfHd4NLW0GQR1XS
TE-12 cell M2HRUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{[5WmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk41OTF2IN88US=> Mn6zV2FPT0WU
TE-8 cell MoftS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFzB[4tKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43ODh7IN88US=> MX;TRW5ITVJ?
TE-9 cell NFPQV|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoOxTY5pcWKrdHnvckBw\iCqdX3hckBVTS17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{[uOlM5OSEQvF2= MVrTRW5ITVJ?
TGW cell NWXYNplwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4LOSGlvcGmkaYTpc44hd2ZiaIXtZY4hXEeZIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuN|U4PyEQvF2= NWm4OZJHW0GQR1XS
UACC-257 cell MmfYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4K4e2lvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz2yOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjdyNkK1JO69VQ>? M33Bd3NCVkeHUh?=
WSU-NHL cell NWfLSYNST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnW5TY5pcWKrdHnvckBw\iCqdX3hckBYW1VvTljMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlcvOTlyNzFOwG0> MXLTRW5ITVJ?
no-10 cell NFi0dlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{D1NGlvcGmkaYTpc44hd2ZiaIXtZY4hdm9vMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlY3QDR4IN88US=> NHG5dYZUSU6JRWK=
no-11 cell M3KzXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml7vTY5pcWKrdHnvckBw\iCqdX3hckBvdy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS3MlAzPjNizszN NIT5O2pUSU6JRWK=
CAS-1 cell NH7BbYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjOOIpPUW6qaXLpeIlwdiCxZjDoeY1idiCFQWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQDR5IN88US=> M4LXdHNCVkeHUh?=
CCRF-CEM cell NU\0b|g{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mmj5TY5pcWKrdHnvckBw\iCqdX3hckBES1KILVPFUUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjV|OUKg{txO NYPmR|EyW0GQR1XS
CMK cell NX:5OIpnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEGzNlMh|ryP M2\2VHNCVkeHUh?=
COLO-829 cell NGLQUJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnzsTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiyPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjR{Mk[g{txO MlzJV2FPT0WU
COR-L279 cell M{TvUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MonMTY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEK3PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODd|ODFOwG0> NH3nTGlUSU6JRWK=
CP66-MEL cell NHiyWVVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEm3eVVKdmirYnn0bY9vKG:oIHj1cYFvKEOSNk[tUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwNUS5O{DPxE1? NE\XNZZUSU6JRWK=
CRO-AP2 cell NWLse4xXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHNTpd3UW6qaXLpeIlwdiCxZjDoeY1idiCFUl:tRXAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|NkC4PEDPxE1? MkT0V2FPT0WU
CTV-1 cell NYW0[JFrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1rU[WlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46OTR3IN88US=> NUXyZpdjW0GQR1XS
Calu-6 cell MnjjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\KV2RMUW6qaXLpeIlwdiCxZjDoeY1idiCFYXz1MVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Py53OE[g{txO NGqzUo1USU6JRWK=
D-247MG cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYX3Z3F3UW6qaXLpeIlwdiCxZjDoeY1idiCGLUK0O21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54MkixOEDPxE1? NX3BeIxLW0GQR1XS
D-263MG cell NHPwbndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWrPfldvUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yOEWwPUDPxE1? NFrMOXRUSU6JRWK=
D-336MG cell NFnZZ4pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDV2IN88US=> MXfTRW5ITVJ?
D-392MG cell NEi4XphIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzl{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ{ODN7IN88US=> M2LjVnNCVkeHUh?=
D-502MG cell NHfFXI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGDHbVVKdmirYnn0bY9vKG:oIHj1cYFvKERvNUCyUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjV|NEmyJO69VQ>? NGLqVolUSU6JRWK=
D-542MG cell M1rQb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\RXnBMUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{G1NkDPxE1? M{DYWHNCVkeHUh?=
DB cell MkPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDdwMUSxO{DPxE1? NHHkR2RUSU6JRWK=
DEL cell MlvFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMEG4PVgh|ryP MVrTRW5ITVJ?
DMS-114 cell M{jqWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHPQd3FKdmirYnn0bY9vKG:oIHj1cYFvKESPUz2xNVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01QS56NE[4JO69VQ>? M3vBZ3NCVkeHUh?=
DMS-153 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{i5[mlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUG1N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjl7MkOg{txO M2S5cHNCVkeHUh?=
DOHH-2 cell NELEcoRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGD1b4lKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvOjJ5NkSg{txO MkDIV2FPT0WU
DSH1 cell M1e1cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkSzOlI{KM7:TR?= MnPQV2FPT0WU
Daudi cell NWT5cIxWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEH3VGNKdmirYnn0bY9vKG:oIHj1cYFvKESjdXTpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xQThyMjFOwG0> Mlj4V2FPT0WU
EC-GI-10 cell Mmf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkDMTY5pcWKrdHnvckBw\iCqdX3hckBGSy2JST2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ1NjJ3OEmg{txO MoS4V2FPT0WU
ECC4 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXiz[4dKUW6qaXLpeIlwdiCxZjDoeY1idiCHQ1O0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvOTh7NjFOwG0> M{Hm[3NCVkeHUh?=
EM-2 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37Ud2lvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFU2QTRizszN MUfTRW5ITVJ?
ES1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDzTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD13LkW0NFg4KM7:TR?= NWDRPJpDW0GQR1XS
ES3 cell NUmzWHk1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR{LkS3Nlkh|ryP MnLuV2FPT0WU
ES4 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MULJcohq[mm2aX;uJI9nKGi3bXHuJGVUPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN3LkG5OUDPxE1? M{L1cHNCVkeHUh?=
ES6 cell M3\6TGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HiXGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yOFc{OyEQvF2= NH7uXnFUSU6JRWK=
ES7 cell NITpeIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwMkOxNlQh|ryP MX;TRW5ITVJ?
ES8 cell NVPQN45vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVPJcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEG5NlQh|ryP NWi4RpV[W0GQR1XS
EW-18 cell NV\JVoR7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlc2QSEQvF2= NETwd45USU6JRWK=
EW-22 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYCyboMxUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4Njd7NEeg{txO Moi4V2FPT0WU
GCIY cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3KzUWlvcGmkaYTpc44hd2ZiaIXtZY4hT0OLWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuPFA{QDlizszN M33ic3NCVkeHUh?=
GDM-1 cell NHrwfYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjpOIVKdmirYnn0bY9vKG:oIHj1cYFvKEeGTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4{QTF7NjFOwG0> NI\ibnhUSU6JRWK=
GI-1 cell NVj5fFg{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXjvflZ3UW6qaXLpeIlwdiCxZjDoeY1idiCJST2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4xODV{MzFOwG0> NGG3RoVUSU6JRWK=
GI-ME-N cell NIfFfoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfacWJKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB2OUWxJO69VQ>? NUXrSHlSW0GQR1XS
GR-ST cell NWP0bmJRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVK5TmI6UW6qaXLpeIlwdiCxZjDoeY1idiCJUj3TWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njd7MEKg{txO NHG3bmxUSU6JRWK=
GT3TKB cell NHLhU3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWr0bpo{UW6qaXLpeIlwdiCxZjDoeY1idiCJVEPUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZyM{i5JO69VQ>? MXfTRW5ITVJ?
HAL-01 cell MkewS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3npeWlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QTdzMjFOwG0> MVTTRW5ITVJ?
HCC1599 cell NF7BZYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mof3TY5pcWKrdHnvckBw\iCqdX3hckBJS0NzNUm5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|cvPjBzMTFOwG0> M4f0TXNCVkeHUh?=
HCC2218 cell NV\zdWx6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEHmS45KdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{KyNVgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy5|OEO0JO69VQ>? NYDwUYZ5W0GQR1XS
HD-MY-Z cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYe1b|d4UW6qaXLpeIlwdiCxZjDoeY1idiCKRD3NXU1bKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwMkG0OkDPxE1? NWnFW3BmW0GQR1XS
HL-60 cell M4C2PGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVTJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNlEyPCEQvF2= M1\JZ3NCVkeHUh?=
HOP-62 cell M17LbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1L0d2lvcGmkaYTpc44hd2ZiaIXtZY4hUE:SLU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlMvQTV{NzFOwG0> MYrTRW5ITVJ?
HT cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\PdIhKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60OFMzOSEQvF2= NF;CRXdUSU6JRWK=
HT-144 cell MofZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1rzW2lvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE46ODZ6NjFOwG0> MV;TRW5ITVJ?
HUTU-80 cell MmLvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGhWXFVvOECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlc5QTh4IN88US=> MlOwV2FPT0WU
IST-MEL1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\IW2lvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLV3FUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi57MEi2JO69VQ>? M{PybHNCVkeHUh?=
IST-SL1 cell MkXlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1e2W2lvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTdyN{mg{txO NXXTOJNVW0GQR1XS
IST-SL2 cell M1H4bmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfoPHFKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ4NkC4JO69VQ>? NYjLdmlPW0GQR1XS
K052 cell NGTuSndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnLKTY5pcWKrdHnvckBw\iCqdX3hckBMODV{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD63OVMxOSEQvF2= M{fxc3NCVkeHUh?=
K5 cell M3jre2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fDT2lvcGmkaYTpc44hd2ZiaIXtZY4hUzViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Mz61PVE2KM7:TR?= MXrTRW5ITVJ?
KALS-1 cell M1i4OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3S0ZWlvcGmkaYTpc44hd2ZiaIXtZY4hU0GOUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvOzl4OTFOwG0> M{Pvd3NCVkeHUh?=
KARPAS-422 cell NXzuNnVyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3niXGlvcGmkaYTpc44hd2ZiaIXtZY4hU0GUUFHTMVQzOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR{LkmxOFIh|ryP MU\TRW5ITVJ?
KARPAS-45 cell MnH6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI\YZnVKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwMUGyOFch|ryP M1q0cXNCVkeHUh?=
KE-37 cell NFTlNHNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT64N|Uh|ryP NWW4ellnW0GQR1XS
KG-1 cell MonBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFz1bFRKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yN{46PzV5IN88US=> M{DxWnNCVkeHUh?=
KGN cell NULJOZdMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPXTY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkW2O|QzKM7:TR?= Ml31V2FPT0WU
KM12 cell M3zIUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVPJcohq[mm2aX;uJI9nKGi3bXHuJGtOOTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkWyPVY1KM7:TR?= NXPUfJZKW0GQR1XS
KMOE-2 cell NHXiSWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4jIOmlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|AvPDV2OTFOwG0> MYXTRW5ITVJ?
KNS-42 cell M{O5bmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfFTY5pcWKrdHnvckBw\iCqdX3hckBMVlNvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlgyQTF3IN88US=> MWnTRW5ITVJ?
KNS-81-FD cell MkjZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGtPWy16MT3GSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM4NjR{NjFOwG0> MUnTRW5ITVJ?
KS-1 cell NU\xV|d1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mlu4TY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wNFQ3KM7:TR?= M{jkWXNCVkeHUh?=
KU812 cell M{fyOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJGtWQDF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkOuOFg1KM7:TR?= M4HHfHNCVkeHUh?=
L-540 cell M1GxU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfYO25KdmirYnn0bY9vKG:oIHj1cYFvKExvNUSwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlAvPzR2NTFOwG0> MmPQV2FPT0WU
LAMA-84 cell NU\6[ZhST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoPnTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjd2MjFOwG0> MYfTRW5ITVJ?
LB1047-RCC cell MlvUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml[2TY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjhwM{i4N{DPxE1? NV;5XmlrW0GQR1XS
LB2241-RCC cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGGy[lJKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61OVM3KM7:TR?= NHy0[mFUSU6JRWK=
LB2518-MEL cell M3v3bWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUToO4E3UW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVQ6Ps7:TR?= MXfTRW5ITVJ?
LB831-BLC cell NEi4VZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\4dWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ6M{GtRmxEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUeyOkDPxE1? Mo\sV2FPT0WU
LB996-RCC cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrtPXJbUW6qaXLpeIlwdiCxZjDoeY1idiCOQkm5Ok1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj63OFMyKM7:TR?= M2LiRnNCVkeHUh?=
LC4-1 cell M3zzb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVTJcohq[mm2aX;uJI9nKGi3bXHuJGxEPC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{KuPFM1OSEQvF2= M1u1SXNCVkeHUh?=
LOUCY cell NX\D[Jh[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3OTY5pcWKrdHnvckBw\iCqdX3hckBNV1WFWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVUzPzZizszN MXXTRW5ITVJ?
LOXIMVI cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE4zOTJ{IN88US=> NYnneng4W0GQR1XS
LS-123 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MojLTY5pcWKrdHnvckBw\iCqdX3hckBNWy1zMkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU4zOjV6IN88US=> M2PKTHNCVkeHUh?=
LU-134-A cell NUGxcYhNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmfTTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{StRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOTRyNkig{txO NFvpO49USU6JRWK=
LU-139 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnHXTY5pcWKrdHnvckBw\iCqdX3hckBNXS1zM{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNk4zOThizszN NYDtU2RyW0GQR1XS
LXF-289 cell Mlv6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWP3U5h[UW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTdwNEO1Ne69VQ>? Mn6xV2FPT0WU
MC116 cell NWrNO4hlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmDLTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS1MlA5PDFizszN MmTMV2FPT0WU
MDA-MB-134-VI cell Mo\IS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\LbZVkUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTN2LW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|kvOjR6NjFOwG0> NXflWJc2W0GQR1XS
MFH-ino cell Ml33S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{niVWlvcGmkaYTpc44hd2ZiaIXtZY4hVU[KLXnuc{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjR|OEOg{txO NWXXb3Y4W0GQR1XS
MHH-NB-11 cell MkLJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInFNVVKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3ORk0yOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwME[2PUDPxE1? NUDHemRIW0GQR1XS
ML-2 cell NUPHfIhrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXz3[3V[UW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{41ODNyNDFOwG0> NUHyTFJsW0GQR1XS
MOLT-13 cell NHzVWFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fUTGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPDN4NUOg{txO MnTBV2FPT0WU
MOLT-16 cell NIH3fIlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFPHem1KdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjFzMU[zJO69VQ>? NVL6OWRpW0GQR1XS
MOLT-4 cell NGX4NVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlWwTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE41OTJ2IN88US=> NHH3OZRUSU6JRWK=
MPP-89 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPycYpKdmirYnn0bY9vKG:oIHj1cYFvKE2SUD24PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjV7MkKg{txO MofaV2FPT0WU
MRK-nu-1 cell NHXMVGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NW\UNI1GUW6qaXLpeIlwdiCxZjDoeY1idiCPUlutcpUuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUe1O|Ih|ryP MkDoV2FPT0WU
MSTO-211H cell MlX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGnxPWtKdmirYnn0bY9vKG:oIHj1cYFvKE2VVF:tNlEyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF{Lki2PUDPxE1? M1SyfXNCVkeHUh?=
MV-4-11 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4nqcmlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTN7MUWg{txO MWTTRW5ITVJ?
NALM-6 cell NH7TU4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\uTpZKdmirYnn0bY9vKG:oIHj1cYFvKE6DTF2tOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTZzMEmg{txO MYXTRW5ITVJ?
NB1 cell M1y1Zmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LEOGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz64OFM3QSEQvF2= MlLHV2FPT0WU
NB10 cell NFPz[2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5DOTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkGzPVE2KM7:TR?= NIDEN29USU6JRWK=
NB12 cell M2DzdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHi1[pZKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk42PjV4IN88US=> MUTTRW5ITVJ?
NB13 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2XlW2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|EzPzhizszN M3LCUXNCVkeHUh?=
NB17 cell M33MOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2XwPWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuOVgxPTFizszN MmWwV2FPT0WU
NB6 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO5TY5pcWKrdHnvckBw\iCqdX3hckBPSjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkW5NVE1KM7:TR?= NIDNSY5USU6JRWK=
NCCIT cell MmG0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUL0[lFGUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQyNjh2NUOg{txO NWPjT3ByW0GQR1XS
NCI-H1155 cell M3rJd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUX0[5ZJUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND6zOFA5KM7:TR?= NFzl[XJUSU6JRWK=
NCI-H1304 cell MlPBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHjnZ4hKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVMxPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLki5PFIh|ryP MXrTRW5ITVJ?
NCI-H1355 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF\DXnhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVM2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwOUSxNUDPxE1? M4\EXXNCVkeHUh?=
NCI-H1395 cell M1i3OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\3TJdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVM6PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lki3PVUh|ryP NYT3NI84W0GQR1XS
NCI-H1417 cell MlPtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mle3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG0NVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjZ5NUKyJO69VQ>? MoD1V2FPT0WU
NCI-H1436 cell NHH3NI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2P1[WlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOFM3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oy56NEGwNUDPxE1? NIi4cm5USU6JRWK=
NTERA-S-cl-D1 cell NHrLbJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXTqOphIUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQDl|NTFOwG0> NW\Udm9bW0GQR1XS
JiyoyeP-2003 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHlVVRKdmirYnn0bY9vKG:oIHj1cYFvKEqreX;5[XAuOjByMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO2MlYzQDRizszN MWXTRW5ITVJ?
In vivo Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats. The reduction of blood pressure was acute and substantial. The maximal effect on blood pressure was observed approximately 2 h after oral gavages. The reduction of blood pressure was accompanied by an acute, dose-dependent increase in heart rate, presumably due to the activation of baroreflex mechanism[1]. ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose, in turn, triggered an increase in VV(voided volume), PVR(post-void residual), VT(volume threshold), VE(voiding efficiency), ICI(intercontraction interval), BC(bladder compliance), and VTNVC(volume threshold to elicit NVC). The inhibition of the ROCK pathway through GSK 269962 appeared to have no effect on either HR(heart rate), SBP(systolic blood pressure), MBP(systolic blood pressure), or DBP(diastolic blood pressure)[2]. NVC:nonvoiding contractions.

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Human primary smooth muscle cells
  • Concentrations: 3 μM
  • Incubation Time: 150 min
  • Method: Human primary smooth muscle cells were serum-starved(cells were grown on coverslips, and at approximately 50% confluence, they were serum-starved overnight) and stimulated with AngII (100 nM) for 2 h. ROCK inhibitors (3 μM for SB-772077-B or GSK269962A) were added 30 min before AngII stimulation, and cells were fixed and stained with rhodamine phalloidin. Confocal images of actin stain were obtained.
Animal Research:[2]
  • Animal Models: female Wistar rats
  • Dosages: 5 or 10 mg/kg
  • Administration: intra-arterially

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 607.06
Formula

C29H30N8O5.HCl

CAS No. 2095432-71-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy GSK269962A HCl | GSK269962A HCl supplier | purchase GSK269962A HCl | GSK269962A HCl cost | GSK269962A HCl manufacturer | order GSK269962A HCl | GSK269962A HCl distributor